A5061653997- Organ Transplantation Techniques and Outcomes
- Neonatal Respiratory Health Research
- Renal Transplantation Outcomes and Treatments
- Transplantation: Methods and Outcomes
- Adrenal and Paraganglionic Tumors
- Pituitary Gland Disorders and Treatments
- Pancreatic function and diabetes
- Pancreatitis Pathology and Treatment
- Pancreatic and Hepatic Oncology Research
- Hormonal Regulation and Hypertension
- Liver Disease and Transplantation
- Diabetes Management and Research
- Cardiac Ischemia and Reperfusion
- Gastrointestinal disorders and treatments
- Diabetes and associated disorders
- Inhalation and Respiratory Drug Delivery
- Metabolism and Genetic Disorders
- Silk-based biomaterials and applications
- Biopolymer Synthesis and Applications
- Epigenetics and DNA Methylation
- Neuroendocrine Tumor Research Advances
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Neurobiology and Insect Physiology Research
- Immune Response and Inflammation
- Pleural and Pulmonary Diseases
Finis Terrae University
2025
Universidad Complutense de Madrid
2004-2022
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias
2010-2016
Instituto de Salud Carlos III
2015-2016
Baylor Scott & White Health
2016
Centro de Investigación Biomédica en Red
2008-2010
Swedish University of Agricultural Sciences
2008
Universitat de Barcelona
1992-2002
Hospital Clínic de Barcelona
1991-1999
BRICHOS domains are encoded in > 30 human genes, which associated with cancer, neurodegeneration, and interstitial lung disease (ILD). The domain from surfactant protein C proprotein (proSP-C) is required for membrane insertion of SP-C has anti-amyloid activity vitro. Here, we report the 2.1 Å crystal structure proSP-C domain, which, together molecular dynamics simulations hydrogen-deuterium exchange mass spectrometry, reveals how may mediate chaperone activity. Observation amyloid...
Spider dragline silk proteins, spidroins, have a tripartite composition; nonrepetitive N-terminal domain, central repetitive region built up from many iterated poly-Ala and Gly rich blocks, C-terminal domain. It is generally believed that the forms intermolecular contacts in fibers, while precise functions of terminal domains not been established. Herein, thermal, pH, salt effects on structure aggregation and/or polymerization recombinant N- domains, segment containing four coblocks,...
Abstract Lung surfactant protein A (SP-A) plays an important function in modulating inflammation the lung. However, exact role of SP-A and mechanism by which affects IFN-γ–induced activation alveolar macrophages (aMϕs) remains unknown. To address these questions, we studied effect human on rat aMϕs stimulated with IFN-γ, LPS, combinations thereof measured induction proinflammatory mediators as well SP-A’s ability to bind IFN-γ or IFN-γR1. We found that inhibited (IFN-γ + LPS)–induced TNF-α,...
Abstract Ten patients who had undergone whole-organ pancreas transplantation and pancreatoduodenocystostomy from a total of 60 simultaneous cadaveric kidney—pancreas transplants met the criteria for graft pancreatitis. This condition is clearly different acute rejection on basis marked hyperamylasaemia significant local findings over allograft. Graft was cause loss in one patients; eight are alive, seven with functioning 61, 30, 27, 25, 21, 18 14 months after transplantation. Two died:...
Abstract Silicosis, a fibrotic lung disease caused by crystalline silica inhalation, presents unique challenges in transplantation. This case reports an unprecedented complication transplant recipient with chronic silicosis. A man his 60 s, post left single-lung transplantation for silica-induced pneumoconiosis, developed acute respiratory deterioration following routine bronchoscopy. Melanoptysis, followed imaging showing extensive inflammatory involvement the transplanted lung, required...
The anionic antimicrobial peptide SP-B(N), derived from the N-terminal saposin-like domain of surfactant protein (SP)-B proprotein, and SP-A are lung anti-infective proteins. SP-A-deficient mice more susceptible than wild-type to infections, bacterial killing is enhanced in transgenic overexpressing SP-B(N). Despite their potential action, vitro studies indicate that several microorganisms resistant In this study, we test hypothesis these proteins act synergistically or cooperatively...
Over the years, a number of different surgical approaches to adrenal glands have been devised. The anterior transabdominal approach is considered be source postoperative morbidity. However, this conviction can changed. laparoscopic was used in four patients. One had right 5 cm nonfunctioning tumor, second 1.8 aldosterone-producing adenoma, third patient 4 adrenocortical and fourth bilateral pheochromocytoma (tumor size 3.5 4.5 left adrenals, respectively). Carbon dioxide pneumoperitoneum...
Surfactant‐like membranes containing the 21‐residue peptide KLLLLKLLLLKLLLLKLLLLK (KL 4 ), have been clinically tested as a therapeutic agent for respiratory distress syndrome in premature infants. The aims of this study were to investigate interactions between KL and lipid bilayers, role both composition structure on surface adsorption activity ‐containing membranes. We used bilayers three‐component systems...
The purpose of this study was to investigate how surfactant membranes can be perturbed by C-reactive protein (CRP) and whether A (SP-A) might overcome CRP-induced membrane alterations. effect CRP on surface adsorption evaluated in vivo after intratracheal instillation into rat lungs. Insertion investigated through monolayer techniques. structure studied differential scanning calorimetry fluorescence spectroscopy microscopy using large giant unilamellar vesicles. Our results indicate that...
In this study we investigated the effect of acute-phase levels C-reactive protein (CRP) on cytokine production by pulmonary macrophages in presence or absence surfactant. Both human alveolar and interstitial as well surfactant were obtained from multiple organ donor lungs. Precultured stimulated with LPS alone together IFN-gamma CRP, surfactant, combinations. Releases TNF-alpha IL-1beta to medium determined. We found that CRP could modulate lung inflammation humans decreasing proinflammatory...
Journal Article Laparoscopic removal of an adrenocortical adenoma Get access L Fernández-Cruz, Fernández-Cruz Department Surgery, School Medicine, University Barcelona, Villarroel 170, 08036 Spain Correspondence to: Professor L. Search for other works by this author on: Oxford Academic Google Scholar G Benarroch, Benarroch E Torres, Torres M Martínez-Martín, Martínez-Martín A Sàenz British Volume 80, Issue 7, July 1993, Page 874, https://doi.org/10.1002/bjs.1800800724 Published: 06 December...
Surfactant protein C (SP‐C) constitutes the transmembrane part of prosurfactant (proSP‐C) and is α‐helical in its native state. The C‐terminal proSP‐C (CTC) localized endoplasmic reticulum lumen binds to misfolded (β‐strand) SP‐C, thereby preventing aggregation amyloid fibril formation. In this study, we investigated structure recombinant human CTC effects CTC–membrane interaction on structure. forms noncovalent trimers supratrimeric oligomers. It contains two intrachain disulfide bridges,...
Quality of life assessment has emerged as an important approach to evaluate the effect pancreas transplantation in diabetic patients with end-stage renal failure (ESRD). The aim this study was impact ESRD treatment modality on quality Type I (insulin-dependent) diabetes mellitus. Thirty-two similar age, sex and duration, treated for more than 1 year simultaneous kidney (Group 1, n = 12), or 2, 10), hemodialysis 3, 10) were studied. assessed using a questionnaire (34 questions 103 possible...
The aim of this study was to investigate whether intratracheal administration a new synthetic surfactant that includes the cationic, hydrophobic 21-residue peptide KLLLLKLLLLKLLLLKLLLLK (KL 4 ), might be effective in reducing ischaemia–reperfusion injury after lung transplantation. Single left transplantation performed Landrace pigs 22 h post-harvest. KL at dose 25 mg total phospholipid·kg body weight −1 (2.5 mL·kg ) instilled 37°C donor (n = 8) prior explantation. Saline ; 37°C) into...
Surfactant protein C (SP-C) is a novel amyloid found in the lung tissue of patients suffering from interstitial disease (ILD) due to mutations gene precursor pro-SP-C. SP-C small α-helical hydrophobic with an unusually high content valine residues. prone convert into β-sheet aggregates, forming fibrils. Nature's way solving this folding problem include BRICHOS domain pro-SP-C, which functions as chaperone for during biosynthesis. Mutations pro-SP-C or linker region lead formation and ILD. In...