A5032770730- Neonatal Respiratory Health Research
- Neuroscience of respiration and sleep
- Respiratory Support and Mechanisms
- Congenital Diaphragmatic Hernia Studies
- Infant Development and Preterm Care
- Pediatric health and respiratory diseases
- Immune Response and Inflammation
- Transplantation: Methods and Outcomes
- Infant Nutrition and Health
- Biopolymer Synthesis and Applications
- S100 Proteins and Annexins
- Acute Ischemic Stroke Management
- Assisted Reproductive Technology and Twin Pregnancy
- Spinal Dysraphism and Malformations
- Biological Activity of Diterpenoids and Biflavonoids
- Effects of Radiation Exposure
- Organ Transplantation Techniques and Outcomes
- Indoor Air Quality and Microbial Exposure
- Traumatic Brain Injury and Neurovascular Disturbances
- RNA Interference and Gene Delivery
- Fetal and Pediatric Neurological Disorders
- Breastfeeding Practices and Influences
- Advanced X-ray and CT Imaging
- Plant Pathogens and Resistance
Doylestown Hospital
2020
Windtree Therapeutics (United States)
2017-2019
Discovery Laboratories (United States)
2004-2015
University of Pittsburgh
1980
Background. Available therapeutic surfactants are either animal-derived or non–protein-containing synthetic products. Animal-derived contain variable amounts of surfactant apoproteins, whereas the older-generation products only phospholipids and lack proteins (SPs). Both decrease morbidity mortality rates associated with respiratory distress syndrome (RDS) among preterm infants, compared placebo. However, excess have been observed surfactants, Evidence suggests that consisting solely can be...
Nasal continuous positive airway pressure (nCPAP) is an accepted mode of respiratory support for preterm infants with insufficiency. To avoid potential sequelae endotracheal (ET) intubation and mechanical ventilation, prophylactic aerosolization surfactant delivered via nCPAP has been attempted limited success.To determine the feasibility safety a peptide-containing synthetic surfactant, Aerosurf® (lucinactant inhalation) was by to at risk distress syndrome (RDS). Neonates were enrolled into...
The benefits of exogenous surfactants for prevention or treatment respiratory distress syndrome are well established, but there is a paucity long-term follow-up data from surfactant-comparison trials.We sought to determine and compare survival pulmonary neurodevelopmental outcomes through 1 year corrected age preterm infants who received lucinactant other in the SELECT (Safety Effectiveness Lucinactant Versus Exosurf Clinical Trial) STAR (Surfaxin Therapy Against Respiratory Distress...
Oxidant injury and lung inflammation in extremely premature infants are associated with the development of bronchopulmonary dysplasia. Surfactant dysfunction resulting from these events may contribute to pathogenesis Treatment exogenous surfactant decrease incidence or severity We conducted a masked, multicenter, multinational, randomized, controlled, pilot study estimate effects treating at high risk for developing dysplasia lucinactant, synthetic, peptide-containing surfactant, on safety...
AbstractContext: Phosgene's primary mode of action is as a pulmonary irritant characterized by its early latent phase where life-threatening, non-cardiogenic edema typically observed 6‐24 h post-exposure.Objective: To develop an inhaled phosgene acute lung injury (ALI) model in C57BL/6 mice that can be used to screen potential medical countermeasures.Methods: A Cannon style nose-only inhalation exposure tower was expose (8 ppm) or air (sham). An lethality study conducted determine the 8 ppm...
Objective: Inhibition of surfactant function and abnormal synthesis lead to dysfunction in children with acute hypoxemic respiratory failure. We evaluated whether intratracheal lucinactant, a synthetic, peptide-containing surfactant, was safe well-tolerated infants failure, assessed its effects on clinical outcomes. Methods Main Results: Infants ≤2 yrs age failure were enrolled phase II, double-blind, multinational, placebo-controlled randomized trial across 36 pediatric intensive care...
Current guidelines for management of respiratory distress syndrome (RDS) recommend continuous positive airway pressure (CPAP) as the primary mode support even in most premature neonates, reserving endotracheal intubation (ETI) rescue surfactant or failure. The incidence and timing ETI practice is poorly documented. In 27 Level III NICUs US (n = 19), Canada 3) Poland 5), demographics baseline characteristics, modalities including ETI, administration caffeine/other methylxanthines, neonatal...
Abstract KL 4 ‐surfactant contains the novel peptide, sinapultide, which mimics properties of hydrophobic pulmonary surfactant protein SP‐B, in a phospholipid formulation and may be lung protective experimental acute respiratory distress syndrome/acute injury. Our objective was to determine role airway delivery murine models hyperoxic lipopolysaccharide (LPS)‐induced injury further explore mechanisms protection. For model, mice exposed 80% O 2 for 6 days received an intranasal bolus vehicle,...
Prevention of bronchopulmonary dysplasia (BPD) in premature-birth babies continues to be an unmet medical need. Intramuscular vitamin A is currently employed preterm neonates prevent BPD but requires intramuscular injections fragile neonates. We hypothesized that noninvasive inhaled delivery A, targeted lung, would a more effective and tolerable strategy. our well-established hyperoxia-injury neonatal rat model, exposing newborn rats 7 days constant extreme (95% O2) hyperoxia, comparing...
The threat of exposure to ionizing radiation from a nuclear reactor accident or deliberate terrorist actions is significant public health concern. lung particularly susceptible radiation-induced injury external sources inhalation radioactive particles fallout. Radiation-induced disease can manifest with an acute pneumonitis and/or delayed effects leading pulmonary fibrosis. As prior warning unlikely, medical countermeasures (MCMs) mitigate that be given in mass-casualty situations many hours...
The aim of this study was to investigate whether intratracheal administration a new synthetic surfactant that includes the cationic, hydrophobic 21-residue peptide KLLLLKLLLLKLLLLKLLLLK (KL 4 ), might be effective in reducing ischaemia–reperfusion injury after lung transplantation. Single left transplantation performed Landrace pigs 22 h post-harvest. KL at dose 25 mg total phospholipid·kg body weight −1 (2.5 mL·kg ) instilled 37°C donor (n = 8) prior explantation. Saline ; 37°C) into...
Background: In preterm infants at risk for RDS, reintubation following surfactant replacement therapy and successful extubation may be associated with poor clinical outcomes. Methods: Initial extubation, reintubation, mortality, major morbidity r
OBJECTIVES Reintubation and subsequent mechanical ventilation (MV) in preterm infants after surfactant replacement therapy are associated with excess morbidity mortality likely increase in-hospital costs. Specific selection for prevention of respiratory distress syndrome (RDS) receiving conventional MV may impact not only clinical outcomes but also pharmacoeconomic outcomes. METHODS We conducted a analysis the reintubation on health care resource utilization. Rates duration were determined...
Xenon- and iodine-enhanced CT of diffuse cerebral circulatory arrestBP Drayer, M Dujovny, SK Wolfson, R Segal, D Gur, Boehnke, G Rao E CookAudio Available | Share