A5012106553- Chronic Lymphocytic Leukemia Research
- Acute Lymphoblastic Leukemia research
- Lymphoma Diagnosis and Treatment
- CAR-T cell therapy research
- CNS Lymphoma Diagnosis and Treatment
- Viral-associated cancers and disorders
- Gut microbiota and health
- Protein Degradation and Inhibitors
- Neutropenia and Cancer Infections
- Respiratory viral infections research
- Mycobacterium research and diagnosis
- Hematopoietic Stem Cell Transplantation
- Cancer Genomics and Diagnostics
- Chronic Myeloid Leukemia Treatments
- Multiple Myeloma Research and Treatments
- Lung Cancer Treatments and Mutations
- Viral Infections and Vectors
- Magnetic confinement fusion research
- Glioma Diagnosis and Treatment
- Fusion materials and technologies
- Biomedical Ethics and Regulation
- Diet and metabolism studies
- interferon and immune responses
- Immune Cell Function and Interaction
- Nuclear reactor physics and engineering
University of Nebraska Medical Center
2020-2025
Susan Thompson Buffett Foundation
2023-2024
Fred and Pamela Buffett Cancer Center
2023-2024
Nebraska Medical Center
2023
University of Wisconsin Carbone Cancer Center
2019-2021
University of Wisconsin–Madison
2016-2021
University of Chicago
2015-2018
UW Health University Hospital
2016-2018
Fusion Academy
2017
Cleveland Clinic Florida
2017
The treatment of relapsed/refractory multiple myeloma (MM) has evolved to include several new options. These combinations with second generation proteasome inhibitors (PI); immunomodulators, monoclonal antibodies, CAR T cells, bispecific selinexor, venetoclax, and many others. Most patients MM undergo cycles remissions relapse, therefore need lines combination therapies. Selecting options for requires consideration resistance status specific classes, patient-specific factors such as age...
Abstract A fusion nuclear science facility (FNSF) could play an important role in the development of energy by providing environment needed to develop materials and components. The spherical torus/tokamak (ST) is a leading candidate for FNSF due its potentially high neutron wall loading modular configuration. key consideration choice configuration range achievable missions as function device size. Possible include: fluence, demonstrating tritium self-sufficiency, electrical self-sufficiency....
Primary systemic light chain amyloidosis (SLCA) is characterized by production of chains that get converted to amyloid fibrils with an affinity for visceral organs and causing organ dysfunction. The therapy SLCA directed recovering the function affected targeting abnormal plasma cell clone slowing deposition fibrils. NCCN Guidelines provide recommendations workup, diagnosis, treatment primary as well previously treated SLCA.
Abstract Data addressing prognostication in patients with HIV related Burkitt lymphoma (HIV-BL) currently treated remain scarce. We present an international analysis of 249 (United States: 140; United Kingdom: 109) HIV-BL from 2008 to 2019 aiming identify prognostic factors and outcomes. With a median follow up 4.5 years, the 3-year progression-free survival (PFS) overall (OS) were 61% (95% confidence interval [CI] 55% 67%) 66% (95%CI 59% 71%), respectively, similar results both countries....
The treatment of Waldenström macroglobulinemia/lymphoplasmacytic lymphoma (WM/LPL) has evolved to include several new options. NCCN Guidelines for WM/LPL provide a framework on which base decisions regarding diagnosis, treatment, assessment response and follow-up both newly diagnosed previously treated WM/LPL.
Mantle cell lymphoma (MCL) is a rare B-cell non-Hodgkin with multiple subtypes including classical mantle (cMCL), the leukemic variant of (LV-MCL), and in situ neoplasia (ISMCN). Their clinical presentations differ significantly range from indolent to very aggressive. The defining genetic feature chief oncogenic mechanism MCL involves t(11;14)(q13;q32) translocation, which results fusion gene that encodes cyclin D1 (CCND1) immunoglobulin heavy chain (IGH). As result significant variation...
"CLO25-054: Long Term Follow Up of Patients Undergoing High Dose Chemotherapy and Autologous or Allogeneic Stem Cell Transplantation for Mantle Lymphoma" published on 28 Mar 2025 by National Comprehensive Cancer Network.
Background: Chronic lymphocytic leukemia (CLL) is the most prevalent adult in Western world. Targeted therapies have made CLL manageable for many patients, but ongoing threat of disease relapse or transformation beckons a deeper understanding pathogenesis, and thus, its durable eradication. This study identifies bile acids (BAs) as elevated peripheral blood patients murine model CLL, comparison to healthy controls. Elevated BA concentrations been associated with intestinal malignancies...
Central nervous system (CNS) involvement in Burkitt lymphoma (BL) poses a major therapeutic challenge, and the relative ability of contemporary regimens to treat CNS remains uncertain. We described prognostic significance incidence recurrence/progression after immunochemotherapy using real-world clinicopathologic data on adults with BL diagnosed between 2009 2018 across 30 US institutions. examined associations baseline involvement, patient characteristics, complete response (CR) rates,...
The gut microbiome is an important feature of host immunity with associations to hematologic malignancies and cellular therapy. We evaluated the dietary intake in patients multiple myeloma undergoing autologous stem cell transplantation. Thirty were enrolled, samples collected at four timepoints: pre-transplant, engraftment, day +100 (D + 100), 9–12 months post-transplant. Microbiome analysis demonstrated a loss alpha diversity engraftment timepoint driven by decreases Blautia, Ruminococcus,...
Redundant tumor microenvironment (TME) immunosuppressive mechanisms and epigenetic maintenance of terminal T cell exhaustion greatly hinder functional antitumor immune responses in chronic lymphocytic leukemia (CLL). Bromodomain extraterminal (BET) proteins regulate key pathways contributing to CLL pathogenesis TME interactions, including function differentiation. Herein, we report that blocking BET protein alleviates networks the repairs inherent defects. The pan-BET inhibitor OPN-51107...
The ARIES team has examined a multitude of fusion concepts over period 25 years. In recent years, the wrapped up Advanced Research, Innovation, and Evaluation Study (ARIES) series by completing detailed design ARIES–Advanced Conservative Tokamak (ARIES-ACT2) power plant—a plant with conservative physics technology, representing tokamak reduced-activation ferritic/martensitic (RAFM) structure dual-coolant lead-lithium blanket. integration nuclear assessments (neutronics, shielding,...
Abstract Chronic lymphocytic leukemia (CLL) cell survival and growth is fueled by the induction of B-cell receptor (BCR) signaling within tumor microenvironment (TME) driving activation NFκB unfolded protein response (UPR). Malignant cells have higher basal levels UPR posing a unique therapeutic window to combat CLL using pharmacologic agents that induce accumulation misfolded proteins. Frontline therapeutics directly target BCR such as Bruton tyrosine kinase (BTK) inhibitors (e.g.,...
B-cell chronic lymphocytic leukemia (CLL) results from intrinsic genetic defects and complex microenvironment stimuli that fuel CLL cell growth through an array of survival signaling pathways. Novel small-molecule agents targeting the receptor pathway anti-apoptotic proteins alone or in combination have revolutionized management CLL, yet therapy carries significant toxicity remains incurable due to residual disease relapse. Single-molecule inhibitors can target multiple disease-driving...
Human parainfluenza virus type 2 (HPIV-2), an important pediatric respiratory pathogen, encodes a V protein that inhibits I interferon (IFN) induction and signaling. Using reverse genetics, we attempted the recovery of panel mutant viruses individually contained one six cysteine-to-serine (residues 193, 197, 209, 211, 214, 218) substitutions, two paired charge-to-alanine (R175A/R176A R205A/K206A) or histidine-to-phenylalanine (H174F) substitution. This mutagenesis was performed using...
Community respiratory viruses (CRV) are important agents of morbidity and mortality within the allogeneic hematopoietic stem cell transplant (HCT) population. Few proven methods to prevent CRV infections exist. No studies have specifically investigated their impact on older patients. We reviewed patients 50 years undergoing HCT between 2009–2013 determine incidence infection using multiplex PCR risk factors for including geriatric assessment (GA). Thirty-two first episode occurred in 118 a...
2087 Background: PCNSL is a rare and aggressive form of NHL in the central nervous system or vitreoretinal space. Despite high initial rates responses to HD-MTX-based induction chemotherapies, most patients relapse two years. R/R associated with poor prognosis, representing clear unmet medical need, as there are no currently approved treatments for this disease. IRAK4 kinase activity required TLR IL-1R signaling variety myeloid lymphoid cell types, including PCNSL. Recruitment these...