Among the numerous chemicals discharged into surrounding environment, bisphenol A (BPA) and octylphenol (OP) have been shown to increase oxidative stress in body by disturbing prooxidant/antioxidant balance of cells. Cinnamon aqueous extract (CAE) is a natural product rich polyphenolic compounds that antioxidant activity. This study was designed investigate protective efficacy CAE against disorders induced BPA OP male albino rats. Animals were divided 6 groups (10 rats each) treated orally,...

Ionizing radiation has cytotoxic and genotoxic effects caused mainly by the oxidative damage induced free radical release. The need for radioprotectives is increasing to protect normal tissues during radiotherapy. In present study, we investigated radioprotective effect of Date syrup in rats subjected whole body at 6 Gy through biochemical, molecular histopathological analysis. Significant elevations were recorded activities serum ALT, AST, ALP LDH levels all lipid profiles parameters, while...

This study evaluates the antitumor efficacy of hesperidin (Hesp) versus cisplatin (Cis) in Ehrlich ascites carcinoma (EAC)-bearing mice, as well its protective effect against Cis-triggered nephrotoxicity. Seventy female mice were allocated into control, Hesp, EAC, Hesp-protected, Hesp-treated, Cis-treated, and Cis+Hesp-treated groups. The inoculation with EAC cells significantly reduced mean survival time, while increased body weight, abdominal circumference, ascitic fluid volume, viable...

Cigarette smoking (CS) has been associated with an increased risk of cognitive disorders. Although HMGB1 connected to various neurological ailments, its role in the pathogenesis CS-induced impairments is undefined. With ability GLP-1 lower expression and improve learning memory performance, we sought assess potential neuroprotective efficacy Crocin (Cro) as a stimulator against impairments, focus on HMGB1-RAGE/TLR4-NF-κB pathway. Fifty adult rats were specified into: Control; Cro (30 mg/kg);...

The present study aimed to investigate the protective effect of argan oil (AO) against nephrotoxic effects following overdose and long-term administration betamethasone (BM). phytochemical compositions AO were assessed using GC/MS. Forty eight male Wister albino rats divided into six groups treated for 3 successive weeks. control group was orally administrated distilled water daily, BM received (1 mg/kg, IM, day after day), AO/0.5 AO/1 (0.5 mL/kg, 1 orally, respectively), + group. results...

Aluminum oxide nanoparticles (Al2 O3 -NPs) are exceedingly used in various industrial and commercial applications, providing growing concerns about their potential adverse impacts on animals human health. Therefore, the present study was conducted to evaluate protective effect of sesamol (SML) against induced hepatorenal toxicity Al2 -NPs. Forty male rats were randomly assigned into four groups treated orally for 28 consecutive days. Control group received distilled water. SML (100 mg/kg...

Ivermectin (IVM), a broad spectrum anthelmintic drug, is considered safe drug; however, there are few reports about its toxic effects in particularly at accidental overdose exposure. Therefore, the current study was designed to investigate potential protective roles of vitamin E (Vit E) and grape seed oil (GSO) against acute hepatorenal toxicity IVM mice. Mice were divided into four equal groups. Control vehicle group administrated corn (0.2 ml/animal), (6.5 mg/kg b.w.), Vit E+IVM (200 b.w.)...

Aflatoxins (AFs), widely distributed food-borne mycotoxins, affect quality and safety of food cause economic losses in livestock. In this study, the protective effect Bee Pollen (BP) against some immunotoxic hazards elucidated from eating AFs-containing diet was investigated Wistar rats. Rats were randomly classified intofour groups treated for 30 days, Group 1; control negative, 2; Total AFs (3 mg kg(-1) basal diet), 3; BP (20 g diet) 4; AFs+BP diet. The immunoprotective revealed terms...

Abstract The present study aimed to investigate the protective potential of naringin (NG) against di-n-butyl phthalate (DBP)- induced testicular damage and impairment spermatogenesis in rats. Forty-two male Wistar albino rats were divided into six equal groups, treated orally, 3 times weekly for 8 successive weeks. Control vehicle group was administrated olive oil, naringin-treated administered NG (80 mg/kg), DBP 250- 500- intoxicated groups received (250 mg/kg) (500 respectively, + 250 500...

Asphyxia is mainly induced by interference with respiration, or lack of oxygen in respired air as entrapment suffocation that may occur animals human. In this study 24 male albino rats were assigned into four equal groups: G1 (control negative); G2 (exposed to asphyxia); G3 (asphyxiated pretreated salbutamol); G4 digoxin). The results revealed no change the time intervals from onset till coma (G2, and G4). Also, all external internal classical signs asphyxia appeared on different asphyxiated...

Alumina (aluminum oxide) nanoparticles (AlNPs) have been categorized among the most important nano-metals, with wide applications in many fields as food, agriculture, industry, engineering, pharmacy, medicine and others. The extensive use of AlNPs results a massive release them into environment resulting potential adverse impacts on animals human health. Toxicokinetic studies demonstrated rapid absorption systemic distribution to different organs. mainly induced their toxic damage by...

The objective of this study was to assess the ameliorative effect naringin (NG) against di-n-butyl phthalate (DBP)-induced testicular injury in rats. Six equal groups were treated orally, 3 times a week for six successive weeks: control vehicle group received olive oil; NG (80 mg/kg); DBP 250 and 500 mg/kg, respectively; NG+DBP (80mg/kg), an hour before administration at respectively. Serum malondialdehyde (MDA) level total antioxidant capacity (TAC), as well pathological changes,...

Cyclophosphamide (CYP), an oxazophosphorine- alkylating agent, is a widely used drug for treatment of neoplastic and severe autoimmune diseases. Adverse effects CYP restrict its therapeutic benefits. Mesna (MS), thiol compound, as protective agent against hemorrhagic cystitis induced by CYP. This study aimed to investigate the potential role raw garlic homogenate (RGH) improving effect mesna toxicity in rats. Thirty male albino rats were divided into five equal groups. Control group, group...

Extensive use of imidacloprid (IMI) insecticide in the agro-vet practices leads to continuous animal and human exposure. Exposure pregnant dams such insecticides results fetal malformations. In light this, present study was designed investigate teratogenic effects two different doses IMI possible mechanistic role oxidative stress. Fifteen females were randomly divided into three equal groups orally treated daily during organogenesis period (6-15th GD), control (distilled water), LD-IMI (45...

Potential fetal adverse effects are well-known for several antibacterial classes.The present study was performed to evaluate the potential teratogenic effect of Tilmicosin (TMS) antibiotic in Sprague Dawley rats.TMS daily administered orally pregnant rats at two dose levels, 250 or 500 mg/kg bw, on 6-15 days gestation.The morphological skeletal malformations were non-significantly different from control values.However, visceral examination revealed elevation percentage intrathoracic and...

Di-n-butyl phthalate (DBP), a ubiquitous plasticizer, is widely used in many industrial products and directly involved numerous health issues.Naringin (NG) dietary flavonoid that possesses benefits.This study aimed to evaluate the ameliorative potential of NG against hepatorenal toxicity DBP.Rats were assigned into six groups, treated orally, 3 times week for 8 consecutive weeks.Control vehicle group received olive oil, (80 mg/kg), DBP 250 500 groups mg/kg, respectively, NG+DBP NG, an hour...

Iron is an important vital micronutrient; nevertheless, iron excess may induce cellular toxicity via mediating reactive oxygen species generation, ensuing in oxidative stress and harm to various organs, including the liver, kidney, heart, others.Iron overload, also called hemochromatosis, most severe manifestation of excessive accumulation that can occur despite body's regulatory processes results a systemic buildup body leading many adverse effects.Several factors contribute consuming...

Episodes of hyperthermia occur frequently from exposure to infections or adverse climatic changes.Such has been linked various detrimental health effects.This study aimed investigate the pathophysiological responses acute versus subacute whole-body (WBH) in rats, particularly on brain, with special reference their medicolegal importance.Rats were randomly assigned three equal groups.The normothermic group was kept at room temperature, hyperthermic (AWBH) subjected long-period WBH as a single...

Green tea aqueous extract (GAE) and thyme (TAE) are natural plant extracts having high anti-oxidative effects. This study was designed to evaluate the protective efficacy of GAE TAE against hepatotoxicity- induced by imidacloprid (IMI) in male albino rats. Treated group received IMI diet at 450 ppm (equivalent 1/10 LD50) for 3 months. Significant increases serum TC, TG, LDL-C VLDL-C levels were recorded while HDL-C level reduced. Serum total protein albumin did not show any significant...

Ehrlich Ascites Carcinoma (EAC) is an experimental transplantable neoplasm, which discovered firstly as a mammary tumor in mouse.Like other cancers growing body cavities, EAC cells fill the mouse peritoneum by rapid division causing local inflammatory reaction, with increasing vascular permeability leading to intense edema formation, cellular migration and progressive ascitic fluid formation.Cisplatin (Cis) one of most frequently used antineoplastic agents for various types cancer.Cisplatin...