Recent studies have indicated that brain atrophy is more closely associated with cognitive impairment in multiple sclerosis (MS) than are conventional MRI lesion measures. Enlargement of the third ventricle shows a particularly strong correlation impairment, suggesting clinical relevance damage to surrounding structures, such as thalamus. Previous imaging and pathology demonstrated thalamic involvement MS. In this study, we tested hypothesis volume lower MS normal subjects, correlates...

Various vasoconstrictors have shown promising results in the management of type 1 hepatorenal syndrome (HRS). However, there are very few studies on vasopressors 2 HRS. Terlipressin has been used commonly; however, it is costly and not available some countries. In this study, we evaluated safety efficacy terlipressin noradrenaline treatment HRS.Forty-six patients with HRS were managed (group A, N = 23) or (Group B, albumin a randomized controlled trial at tertiary centre.HRS reversal could...

Abstract Background: Therapeutic paracentesis in patients with cirrhosis induces arterial vasodilatation, causes a decrease effective blood volume and leads to circulatory dysfunction, which can be prevented by intravenous albumin. However, the use of albumin, being product, is controversial. Recently, terlipressin, vasoconstrictor, has been successfully used combat this adverse effect therapeutic paracentesis. Therefore, aim present study was investigate preventive terlipressin on...

OBJECTIVES Intravenous albumin has been used to prevent paracentesis-induced circulatory dysfunction (PICD) in cirrhotics; however, its use is costly and controversial. Splanchnic arterial vasodilatation primarily responsible for PICD. There are no reports of midodrine the prevention In this pilot study, we evaluated METHODS Forty patients with cirrhosis underwent therapeutic paracentesis or a randomized controlled trial at tertiary center. Effective blood volume was assessed by plasma renin...

Targeting altered pathways during initial stage of hepatocellular carcinoma (HCC) development is viewed as an effective and promising strategy to control this disease. Present study investigated the potential effect lycopene-enriched tomato extract (LycT) on hypoxia-induced factor (HIF)-1α, HOX, VEGF, CD31, matrix metalloproteinase (MMP)-2, MMP-9, alpha fetoprotein (AFP)expression stages N-nitrosodiethylamine (NDEA) induced HCC. Female Balb/c mice (8–10 wk) were assigned 4 groups: control,...

68Ga-Pentixafor positron emission tomography (PET) imaging targets CXCR4 expression which is overexpressed in multiple myeloma (MM). In this study, we evaluated the diagnostic utility of PET/CT for MM and compared results with 18F-fluorodeoxyglucose (18F-FDG) PET/CT.34 (21M; 13F; median age = 57.5 years) treatment naive patients were recruited. All underwent 18F-FDG imaging. Freshly prepared (148-185 MBq) was injected intravenously whole-body (low-dose CT) acquired at 1 h post-injection. The...

The objective of this study was to evaluate the role preoperative 18F-fluorodeoxyglucose-positron emission tomography/computed tomography scanning, lymphoscintigraphy (LS), and sentinel lymph node biopsy in patients with malignant melanoma. Fifty-two (36 men: 16 women; mean age 55.0±13.0 years; median 61 range 17–76 years) melanoma were selected. According latest version American Joint Committee on Cancer staging system, disease initially classified as either stage I or II. other primary...

Splanchnic arterial vasodilatation and subsequent activation of anti-natriuretic vasoconstrictive mechanisms have an important role in cirrhotic ascites. The aim this study was to evaluate the effects midodrine, clonidine, their combination on systemic hemodynamics, renal function, control ascites patients with cirrhosis refractory or recurrent ascites.Sixty were prospectively studied after long-term administration clonidine (n=15) midodrine (n=15), both plus standard medical therapy (SMT),...

Purpose The aim of this study was to evaluate the diagnostic potential 68 Ga-pentixafor PET/CT for in vivo CXCR4 receptors imaging glioma and its possible role response assessment radiochemotherapy (R-CT). Methods Nineteen (12 men, 7 women) patients with glioblastoma multiforme (GBM) underwent PET/CT, contrast-enhanced MR, MR spectroscopy. Patients were divided 2 groups, that is, group I presurgical (n = 9) which scanning done before surgery, PET findings correlated receptors’ density. II...

68Ga-Pentixafor PET/CT targets CXCR4 receptors and provides superior diagnostic accuracy in multiple myeloma (MM) compared with 18F-FDG PET/CT. However, its role response evaluation remains unexplored. We propose a PET/CT-based criterion evaluate utility International Myeloma Working Group (IMWG) criteria response. In this prospective single-center study, 40 treatment-naive patients were recruited between February 2021 April 2023. Both performed at baseline follow-up (7.2 mo-median)....

A 69-year-old man, with a known case of metastatic castration-resistant prostate cancer (mCRPC) underwent 68Ga-PSMA PET/CT and 99mTc-PSMA for evaluation disease burden response assessment to 177Lu-PSMA therapy. provided mirror image 68Ga-PSMA. This suggests the potential SPECT/CT PSMA-based radioligand therapies in advanced-stage mCRPC patients, especially when is not available.

A 40-year-old man with newly diagnosed multiple myeloma underwent both 68 Ga-Pentixafor and 18 F-FDG PET/CT. Extramedullary laryngeal involvement was noted on modalities in addition to diffuse marrow focal lesions. PET/CT is increasingly used demonstrates similar diagnostic performance as We present a rare case of extramedullary at baseline

Accurate imaging of patients with possible recurrent colorectal cancer (CRC) is vital, as it now clear that curative surgery still for a proportion metastatic disease. Follow-up usually performed carcinoembryonic antigen (CEA) level, computerized tomography (CT) and other conventional techniques, but in the last few years, functional using integrated positron emission CT (PET/CT) being used increasingly to identify disease.To evaluate usefulness PET/CT follow-up postoperative CRC rising CEA...

In this study we sought to assess the efficacy of a technetium-99m (Tc-99m)-labeled third-generation cephalosporin as an infection imaging agent in accurate detection sites bacterial vivo.Ceftriaxone (CRO) was formulated into ready-to-use single-vial cold kit with shelf-life over 6 months and successfully labeled technetium. The radiolabeled drug, Tc-99m-CRO, subjected following preclinical evaluations: radiochemical purity, vitro vivo stability, binding assay, pharmacokinetic studies...

The aim of the present study was to compare therapeutic efficacy 153Sm-EDTMP and 177Lu-EDTMP in pain palliation cancer patients with skeletal metastases.Thirty (25 M:5 F, mean age: 66.0 ± 14.7 years) breast/prostate documented metastases were recruited prospectively. Twenty considered randomly for treatment 10 patients, respectively. Using fixed dose 37.0 MBq/kg body weight each, administered doses 2,155.2 419.6 MBq (1,347-2,857) 1,935.1 559.4 (1,073-2,627), Anterior posterior whole images...

<h3>Objective:</h3> To evaluate the incidence, distribution, and course of squamous cell carcinoma (SCC) upper aerodigestive tract in patients infected with human immunodeficiency virus (HIV) compare it to SCC non—HIV-infected patients. <h3>Design:</h3> Case-control study all during a 9.5-year period from January 1985 through June 1994. <h3>Setting:</h3> Two academic tertiary care centers metropolitan location. <h3>Participants:</h3> Five hundred thirty-nine (18 95 years old) tract....

Pleural effusion in cirrhotic patients (hepatic hydrothorax) may result from migration of ascitic fluid across defects the diaphragm. Biochemical analysis and pleural provides only indirect information about nature origin effusion. The present study was performed order to demonstrate presence/absence peritoneo-pleural communication by radioisotope imaging.Ten with ascites were studied 99mTc sulfur colloid scintigraphy look for movement radiotracer peritoneal cavity. Serum-ascitic albumin...