A5003920446- Radiopharmaceutical Chemistry and Applications
- Medical Imaging Techniques and Applications
- Glioma Diagnosis and Treatment
- Amino Acid Enzymes and Metabolism
- Radiomics and Machine Learning in Medical Imaging
- Peptidase Inhibition and Analysis
- Effects of Radiation Exposure
- Click Chemistry and Applications
- Lanthanide and Transition Metal Complexes
- Nanoparticle-Based Drug Delivery
- Chemical Synthesis and Analysis
- Chemical Reactions and Isotopes
- Receptor Mechanisms and Signaling
- Cancer, Hypoxia, and Metabolism
- Neuroscience and Neuropharmacology Research
- Advanced biosensing and bioanalysis techniques
- Monoclonal and Polyclonal Antibodies Research
- Dental materials and restorations
- Orthopedic Infections and Treatments
- Medical Imaging and Pathology Studies
- RNA Interference and Gene Delivery
- Pleural and Pulmonary Diseases
- Epigenetics and DNA Methylation
- Dental Implant Techniques and Outcomes
- Synthesis and Biological Evaluation
Institute of Nuclear Medicine & Allied Sciences
2015-2024
Defence Research and Development Organisation
2012-2024
All India Institute of Medical Sciences Rishikesh
2024
All India Institute of Medical Sciences Bhopal
2024
Indian Institute of Technology Roorkee
2024
All India Institute of Medical Sciences Raipur
2024
People’s University
2015-2023
Cyclotron (Netherlands)
2018-2020
Post Graduate Institute of Medical Education and Research
2018
Ministry of Defence
2016
This study aimed to investigate the potential of hybrid gadolinium (Gd)-enhanced F-fluoroethyl-L-tyrosine (F-FET) PET/MRI in distinguishing recurrence from radiation necrosis using simultaneously acquired multiple structural and functional parameters.Twenty-six patients (5 female 21 male patients; mean ± SD age, 51.58 15.97 years) with single or contrast-enhancing brain lesions (n = 32) on MRI after surgery therapy were evaluated Gd-enhanced F-FET PET/MRI. They then followed up resurgery...
Natural plant extract, namely acemannan (Ac) and curcumin (Cur), coencapsulated pluronic micelles, showing thermoresponsive properties, were designed for efficient safe in vivo wound healing applications. Ac Cur, widely used antimicrobials, find limited applications because of their low stability, short biological half-life, poor solubility, bioavailability. Herein, we report the extraction from aloe vera coencapsulation it with Cur micelles to take advantage combined effects both...
Purpose: Neuroendocrine tumors often present a diagnostic and therapeutic challenge. We have aimed to synthesize develop biodegradable nanoparticles of somatostatin analogue, octreotide for targeted therapy human neuroendocrine pancreatic tumor.Methods: Direct solid phase peptide synthesis was done. Octreotide loaded PCL/PEG were prepared by solvent evaporation method characterized transmission electron microscopy, differential scanning calorimetery (DSC), Zeta potential measurement studies....
Cannabidiol (CBD) has been shown to slow cancer cell growth and is toxic human glioblastoma lines. Thus, CBD could be an effective therapeutic for glioblastoma. In the present study, we explored anticancer effect of cannabidiol loaded magnesium-gallate (CBD/Mg-GA) metal-organic framework (MOF) using rat glioma brain (C6) line. Bioactive microporous magnesium gallate MOF was employed simultaneous delivery two potential agents (gallic acid CBD) cells. Gallic (GA), a polyphenolic compound, part...
In this study we sought to assess the efficacy of a technetium-99m (Tc-99m)-labeled third-generation cephalosporin as an infection imaging agent in accurate detection sites bacterial vivo.Ceftriaxone (CRO) was formulated into ready-to-use single-vial cold kit with shelf-life over 6 months and successfully labeled technetium. The radiolabeled drug, Tc-99m-CRO, subjected following preclinical evaluations: radiochemical purity, vitro vivo stability, binding assay, pharmacokinetic studies...
Noninvasive imaging is a powerful tool for early diagnosis and monitoring of various disease processes, such as infections. An alarming shortage infection-selective radiopharmaceuticals exists overcoming the diagnostic limitations with unspecific tracers 67/68 Ga-citrate or 18 F-FDG. We report here TBIA101, an antimicrobial peptide derivative that was conjugated to DOTA radiolabeled 68 Ga subsequent in vitro assessment vivo infection using Escherichia coli -bearing mice by targeting...
Methionine-diethylenetriaminepentaaceticacid-methionine [DTPA-bis(Met)] was synthesized by covalently conjugating two molecules of methionine (Met) to DTPA and labeled with 99mTc in high radiochemical purity specific activity (166−296 MBq/μmol). Kinetic analysis showed Km 12.95 ± 3.8 nM a maximal transport rate velocity (Vmax) 80.35 0.42 pmol μg protein−1 min−1 99mTc-DTPA-bis(Met) U-87MG cells. DTPA-bis(Met) had dissociation constants (Kd) 0.067 0.077 BMG, respectively. 35S-methionine efflux...
Posttherapy changes in treated glioma patients cannot be reliably differentiated from tumor recurrence. We evaluated the role of Tc-methionine SPECT/CT for detection recurrent and compared same with F-FDG PET/CT contrast-enhanced MRI (CeMRI).Forty-four histologically proven, previously clinical suspicion recurrence were prospectively enrolled study. Of these 44 patients, 39 (28 male 11 female subjects; age, 38.05 ± 9.7 years) underwent SPECT/CT, PET/CT, CeMRI brain included final analysis....
Amino acid positron emission tomography (PET) imaging plays a significant role in the diagnosis of gliomas and differentiating tumor recurrence from necrosis. In this study, authors evaluated diagnostic efficacy [
Bleomycin (BLM) is an effective curative option in the management of several malignancies including pleural effusions; but pulmonary toxicity, comprising pneumonitis and fibrosis, poses challenge its use as a front-line chemotherapeutic. Although Amifostine has been found to protect lungs from toxic effects radiation BLM, application limited due associated toxicity unfavorable route administration. Therefore, there need for selective, potent, safe anti-fibrotic drugs. The current study was...
Purpose In this study, 99m Tc MDM (bis-methionine-DTPA) SPECT was used for the detection and differentiation of recurrent/residual glioma from radiation necrosis results were compared with dynamic susceptibility contrast-enhanced (DSCE)-MRI clinical findings. Materials Methods Twenty-eight patients (18 men 10 women; mean ± SD age, 41.4 15.03 years) histologically proven (grade IV, 14; grade III, 7; II, 7) who planned postsurgical standard radio/chemo therapy recruited prospectively. All...
Abstract A novel SiX–dipropargyl glycerol scaffold (X: H, F, or 18 F) was developed as a versatile prosthetic group that provides technical advantages for the preparation of dimeric radioligands based on silicon fluoride acceptor pre‐ post‐labeling with fluorine‐18. Rapid conjugation takes place in microwave‐assisted click under mild conditions. Thus, bivalent homodimeric derivatized radioligand, [ F]BMPPSiF, enhanced affinity by using conjugation. High uptake radioligand demonstrated 5‐HT...
Gamma Glutamyl Transferase (GGT) is an important biomarker in malignant cancers. The redox processes ensuing from GGT-mediated metabolism of extracellular GSH are implicated critical aspects tumor cell biology. Reportedly, Glutathione monoethyl ester (GSHMe) a substrate GGT, which has been used for its rapid transport over glutathione. Exploring GGT to be target, homobivalent peptide system, DT(GSHMe)2 was designed target GGT-over expressing tumors diagnostic purposes. synthesized,...
Acetylcholinesterase (AChE) has been an important biomarker for diagnosing Alzheimer's disease (AD), due to reduction in AChE activity post-mortem brains of AD patients. A potent, selective, and reversible homodimeric inhibitor AChE, 5-amino- N1, N3-bis(2-(1,2,3,4-tetrahydroacridin-9-ylamino)ethyl)isophthalamide (compound 4), was synthesized by using 9-alkyl(1,2,3,4-tetrahydroacridine) pharmacophore with appended functionality. In the present work, we report synthesis this bivalent AChE. The...
A new macrocyclic system 2,2'-(12-amino-11,13-dioxo-1,4,7,10-tetraazacyclotridecane-4,7-diyl)diacetic acid (ATRIDAT) was designed for coordinating metals in +2 and +3 oxidation states particularly 68Ga(III), PET imaging. ATRIDAT conjugated to d-biotin pretargeting via biotin-avidin interaction. This model provides high tumor targeting efficiency stability biotinidase activity leading modest signal amplification at the site. Cyclization of triethylenetetramine with protected diethylamino...
The bivalent ligand approach is very promising and can give rise to molecular probes with enhanced conformational flexibility for tissue selective modulation. In this study we describe the synthesis of a homodimeric 5-HT1A receptor by incorporating two identical pharmacophores , 1-(2-methoxyphenyl)piperazine, linked through DTPA. This derivative was efficiently synthesized characterized 1H, 13C NMR mass spectroscopy. 99mTc-labeling performed high radiolabeling yield (>95%) radiochemical...