A5081071996- Cardiac electrophysiology and arrhythmias
- Cardiac Arrhythmias and Treatments
- Cardiomyopathy and Myosin Studies
- Cardiac pacing and defibrillation studies
- RNA and protein synthesis mechanisms
- Viral Infections and Immunology Research
- Bacteriophages and microbial interactions
- Cancer therapeutics and mechanisms
- RNA Research and Splicing
- Congenital heart defects research
- HIV Research and Treatment
- Antibiotic Resistance in Bacteria
University of Amsterdam
2007-2024
Amsterdam University Medical Centers
2021-2024
University of Southern California
2024
University Medical Center Utrecht
2022
Amsterdam UMC Location University of Amsterdam
2007
Genomic RNA circularization has been proposed for several viruses. In this study, we examined if the 5′ and 3′ ends of 9-kb HIV-1 genome can interact. vitro assays demonstrated a specific interaction between transcripts encompassing terminal 1 kb, suggesting that circularize. Truncation indicated 5′–3′ is formed by 600–700 nt in gag open reading frame 123 genomic RNA. Detailed structure probing indicates sequences flanking TAR hairpin interact with complementary gene. Phylogenetic analysis...
Abstract Genetic missense variants in TNNI3K, encoding troponin‐I interacting kinase, have been associated with dilated cardiomyopathy (DCM) and observed families supraventricular tachycardias (SVT). Previously, a family harboring the TNNI3K ‐c.1615A > G (p.Thr539Ala) variant presented congenital junctional ectopic tachycardia (CJET), an arrhythmia that arises from atrioventricular (AV) node His bundle. However, this was relatively small four‐generational limited genetic testing ( N = 3)....
BACKGROUND: Genetic variants in TNNI3K (troponin-I interacting kinase) have previously been associated with dilated cardiomyopathy (DCM), cardiac conduction disease, and supraventricular tachycardias. However, the link between these phenotypes shows a lack of consensus concerning phenotype protein function. METHODS: We describe systematic retrospective study cohort patients undergoing genetic testing for arrhythmias including . further performed burden UK Biobank. For 2 novel variants, we...
Background The phosphoinositide 3-kinase (PI3K) signaling pathway is an interesting target in cancer treatment. awareness of the proarrhythmic risk PI3K inhibitors was raised because also involved regulating toward cardiac ion channels. Canine cardiomyocytes treated with show increased action potential duration and reduced repolarizing currents. Now, effect chronic treatment PI3K/mTOR inhibitor GSK2126458 (omipalisib) investigated atrioventricular (AV) block dog model. Methods Purpose-bred...
The acquisition of multidrug resistance by pathogenic bacteria is a potentially incipient pandemic. Horizontal transfer DNA from mobile integrative conjugative elements (ICEs) provides an important way to introduce genes that confer antibiotic (Ab)-resistance in recipient cells. Sizable numbers SXT/R391 ICEs encode hypermutagenic Rum polymerase (Rum pol), which has significant homology with Escherichia coli pol V. Here, we show even under tight transcriptional and post-transcriptional...