A5100704128- Synthesis and properties of polymers
- Epoxy Resin Curing Processes
- Microstructure and mechanical properties
- Neuroscience and Neuropharmacology Research
- Neurological Disorders and Treatments
- Silicone and Siloxane Chemistry
- Polymer Nanocomposites and Properties
- biodegradable polymer synthesis and properties
- Tribology and Wear Analysis
- Superconducting Materials and Applications
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pulmonary Hypertension Research and Treatments
- HIV Research and Treatment
- Mitochondrial Function and Pathology
- Particle accelerators and beam dynamics
- Conducting polymers and applications
- Sarcoidosis and Beryllium Toxicity Research
- Membrane Separation and Gas Transport
- Advanced materials and composites
- Nanocomposite Films for Food Packaging
- Fuel Cells and Related Materials
- Biochemical effects in animals
- Tropical and Extratropical Cyclones Research
- Meteorological Phenomena and Simulations
- Birth, Development, and Health
Sechenov University
2009-2025
Institute of Macromolecular Compounds
2016-2025
Petersburg Nuclear Physics Institute
2024-2025
Kurchatov Institute
2024-2025
M.N. Mikheev Institute of Metal Physics
2007-2025
Ural Federal University
2023
Development Agency of Serbia
2019-2022
Peoples' Friendship University of Russia
2020-2021
Institute of Cytology and Genetics
2018-2021
Nikiforov Russian Center of Emergency and Radiation Medicine
2020
The endosomal sorting complex ESCRT-III, which is formed by the structurally related CHMP proteins, engaged HIV-1 to promote viral budding. Here we show that progressive truncations into C-terminal acidic domains of proteins trigger an increasingly robust anti-HIV budding activity. Together with biochemical evidence for specific intramolecular interactions between basic and halves CHMP3 CHMP4B, these results suggest are autoinhibitory. half also interacts endosome-associated ubiquitin...
Введение.Исследование посвящено изучению детерминант качества университетского образования с точки зрения студентов, являющихся ключевым звеном на рынке образовательных услуг.Авторам представляется актуальной задача выявления факторов, влияющих удовлетворенность студентов качеством образования, и их ранжирование применительно к современному этапу развития российского высшего
Nef is a virulence factor of HIV-1 and other primate lentiviruses that crucial for rapid progression to AIDS. In cell culture, increases the infectivity progeny virions by an unknown mechanism. We now show dynamin 2 (Dyn2), key regulator vesicular trafficking, binding partner required its ability increase viral infectivity. Dominant-negative Dyn2 or depletion small interfering RNA potently inhibited effect on Furthermore, in Dyn2-depleted cells, this function could be rescued ectopically...
HIV-1 Gag engages components of the ESCRT (endosomal sorting complex required for transport) pathway via so-called L (late-assembly) domains to promote virus budding. Specifically, PTAP (Pro-Thr-Ala-Pro)-type primary domain recruits ESCRT-I by binding Tsg101 (tumour susceptibility gene 101), and an auxiliary LYPXnL (Leu-Tyr-Pro-Xaan-Leu)-type ESCRT-III-binding partner Alix [ALG-2 (apoptosis-linked 2)-interacting protein X]. The structurally related CHMPs (charged multivesicular body...
To exit infected cells, human immunodeficiency virus type 1 (HIV-1) exploits the vacuolar protein-sorting pathway by engaging Tsg101 and ALIX through PTAP LYPx(n)L late assembly (L) domains. In contrast, less-complex retroviruses often use PPxY L domains to recruit Nedd4 family ubiquitin ligases. Although HIV-1 Gag lacks motifs, we now show that budding of various L-domain mutants is dramatically enhanced ectopic Nedd4-2s, a native isoform with truncated C2 domain. The effect Nedd4-2s on...
ABSTRACT Human immunodeficiency virus type 1 (HIV-1) and other retroviruses harbor short peptide motifs in Gag that promote the release of infectious virions. These motifs, known as late assembly (L) domains, recruit a cellular budding machinery is required for formation multivesicular bodies (MVBs). The primary L domain HIV-1 maps to PTAP motif p6 region engages MVB pathway by binding Tsg101. Additionally, harbors an auxiliary binds V ALIX, another component pathway. We now show ALIX also...
Retroviruses engage the ESCRT pathway through late assembly (L) domains in Gag to promote virus release. HIV-1 uses a PTAP motif as its primary L domain, which interacts with ESCRT-I component Tsg101. In contrast, certain other retroviruses primarily use PPxY-type domains, constitute ligands for NEDD4-type ubiquitin ligases. Surprisingly, although lacks PPxY motifs, release of domain mutants is potently enhanced by ectopic NEDD4-2s, native isoform naturally truncated C2 that appears account...
The SF1 helicase MOV10 is an antiviral factor that incorporated into human immunodeficiency virus type 1 (HIV-1) virions. We now report HIV-1 virions also incorporate UPF1, which belongs to the same subfamily as and functions in nonsense-mediated decay (NMD) pathway. Unlike ectopic MOV10, overexpression of UPF1 does not impair infectivity progeny However, becomes a potent inhibitor virion when residues required for its activity are mutated. In contrast, equivalent mutations abolish MOV10....
New aromatic co-polyamide-imides (coPAIs) containing both carboxyl and hydroxyl groups in the repeating units were synthesized for first time. Transport, thermal morphological properties of dense nonporous membranes from PAIs obtained using diacid chloride 2-(4-carboxyphenyl)-1,3-dioxoisoindoline-5-carboxylic acid diamines 5,5′-methylene-bis (2-aminophenol)) 3,5-Diaminobenzoic acid, taken molar ratios 7:3, 1:1, 3:7, have been studied. High levels membrane permeability accompanied by high...
Vertigo is a common symptom encountered by neurologists in clinical practice. Position-dependent vertigo can occur at the onset of autoimmune encephalitis, often being misinterpreted as benign paroxysmal positional (BPPV). This study describes case patient with encephalitis associated GAD65 antibodies, who initially presented systemic vertigo.
The paper describes changes in the structure, morphology, mechanical and thermal properties of porous film samples poly(4,4′-oxidiphenylene)pyromellitimide prepared as a result selective destruction urethane blocks copolymers composed pyromellitimide polyurethane blocks. initial new composition statistical copoly(urethane-imide)s (CoPUIs) were via polycondensation methods using pyromellitic dianhydride (PMDA), 4,4′-oxidyaniline (ODA), 2,4-toluylenediisocyanate (TDI), well polycaprolactone...
Abstract The article presents data on the method of obtaining porous nonwoven polyimide fabrics (membranes), their deformation and strength characteristics, heat resistance, surface properties. membranes are produced as a result multistep processing copoly(urethane‐imides) prepolymers that includes synthesis copoly(urethane‐amiс acids) given chemical composition, molding (mats) by electrodeposition copoly(urethane‐amic acids), compaction volumetric structure electrodeposited calendering hot...
Abstract In the 5G field, there is a growing demand for materials with ultra‐low dielectric constant values that are able to maintain their and mechanical characteristics in wide range of temperatures frequencies electric fields. this work, heat‐resistant composites based on salt polyamic acid from pyromellitic dianhydride PMDA 4,4′‐oxydianiline ODA modified SiO 2 particles were obtained by electrospinning. The prepared demonstrated permittivity. (ε′) composite nonwoven varied 1.74 1.35...
The Nef protein of HIV-1 and the unrelated glycoGag a murine leukemia virus similarly prevent uptake antiviral host proteins called SERINC3 SERINC5 into particles, which enhances their infectiousness. We now show that although both SERINC antagonists can in principle enhance replication, is unable to substitute for primary human cells T cell line MOLT-3. In MOLT-3 cells, remained crucial replication even absence SERINC5. pronounced effect on spreading correlated with ability engage cellular...
Nowadays potentialities of obtaining bulk nanostructured materials with unique properties by various techniques severe plastic deformation (SPD) are comprehensively studied, and niobium, being a refractory, but enough metal, is an ideal object for such studies. Besides, niobium metal special interest as advanced functional material, one the main constituents important electro-technical high-strength Cu–Nb composites multifilamentary Nb3Sn-based NbTi superconductors. The present paper...