A5027035357- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Essential Oils and Antimicrobial Activity
- Crystallography and molecular interactions
- Free Radicals and Antioxidants
- Mesenchymal stem cell research
- Tissue Engineering and Regenerative Medicine
- Metal complexes synthesis and properties
- Phytochemistry and Biological Activities
- Flame retardant materials and properties
- Computational Drug Discovery Methods
- Organophosphorus compounds synthesis
- Bone Tissue Engineering Materials
- Cancer Cells and Metastasis
- Synthesis of Organic Compounds
- Electrospun Nanofibers in Biomedical Applications
- Angiogenesis and VEGF in Cancer
- Fungal Biology and Applications
- Bee Products Chemical Analysis
- Synthesis and biological activity
- Phytochemicals and Antioxidant Activities
- Nanoparticle-Based Drug Delivery
- Marine Sponges and Natural Products
- Bioactive Natural Diterpenoids Research
- Cancer Mechanisms and Therapy
Tokat Gaziosmanpaşa Üniversitesi
2017-2025
Pharmaceutical Biotechnology (Czechia)
2023
Abstract This study presents the first findings regarding extraction, isolation, enzyme inhibition, and antioxidant activity. The oral mucosal wound‐healing process was investigated using propolis water extract (PWE) incubation with gingival fibroblast cells concluded that effective on pattern compared to untreated controls. Additionally, phenolic compounds (fraxetin, apigenin, galangin, pinobanksin, chrysin, etc.) were isolated from propolis, their chemical structures elucidated...
Cancer stem cells drive tumor initiation, metastasis, drug resistance, and recurrence, making them critical therapeutic targets. This study investigated two isoeugenol‐derived polyphenolic compounds, designated as 1 2, in breast, prostate, colon cancer using monolayer three‐dimensional tumoroid models. After 48 hours, both compounds significantly inhibited proliferation. In prostate cells, compound 2 exhibited a lower half‐maximal inhibitory concentration (17.18 µM) than (21.04...
A new series of ruthenium(<sc>ii</sc>) complexes <bold>7–11</bold> containing the –NN– group are synthesized and characterized <italic>via</italic> elemental analysis, IR, UV-visible <sup>1</sup>H–<sup>13</sup>C NMR spectroscopy.
AbstractIn this study, the condensation reaction of hexachlorocyclotriphosphazene, N3P3Cl6 (HCCP) with N1,N3-bis(furan-2-ylmethyl)-1,3-diamino-propane (1) yielded tetrachlorobis(2-furanyl-methyl)monospiro(N/N)cyclotriphosphazene (2). Fully substituted tetraaminobis(2-furanylmethyl)-spiro(N/N)cyclotriphosphazenes (2a and 2b) were obtained by Cl replacement reactions excess pyrrolidine piperidine, respectively, using dry THF under reflux 2. The structures phosphazenes confirmed data elemental...
Abstract The purpose of the present study was in vitro determination combined effects doxorubucin and 5-fluorouracil by 2D 3D culture conditions on breast cancer using MCF-7 cell line CSCs isolated from these cells. In first stage this study, CSC isolation their characterization were performed. next experimental period, antiproliferative 5-Fu Dox demonstrated 2D. To evaluate synergistic/antagonistic chemotherapeutics, CI calculated. Additionally, tumor spheroids used as another model. last...
The starting compound, tetrachloro-4-fluorobenzyl-spiro(N/O)cyclotriphosphazene (2), was synthesized from the substitution reaction of hexachlorocyclotriphosphazatriene (N3P3Cl6; trimer; HCCP) with sodium 3-(4-fluorobenzylamino)-1-propanoxide (1). Reactions spiro (2) excess 1-(2-aminoethyl)-piperidine, 4-(2-aminoethyl)-morpholine, 1-(2-hydroxyethyl)piperidine and 4-(2-aminoethyl)morpholine yielded fully substituted cyclotriphosphazene derivatives (2a–2d), respectively. Elemental analysis,...
Breast cancer is known as the most common type of invasive in women. It well-known that phenolic compounds play an important role treatment this disease. This study hypothesized isoeugenol based two polyphenolic 1 and 2 exerts its anti-proliferative effects through induction apoptosis cell migration arrest on human breast cell. Based hypothesis, aimed to investigate anti-proliferative, anti-migrative these their possible basic molecular mechanisms action MCF-7 lines. As a result,...
Objective: For in vitro tissue engineering urology, stem cells are commonly isolated from specimens obtained during open or endoscopic surgery.Within the context of present study our aim was to isolate human urine by an alternative and safe technique rather than using indicated method.Material methods: After samples had been collected young healthy donors via urethral catheterization, were precipitated centrifugation cultured.Following this isolation procedure, characterized...
Herbal medicines are being used for primary health care due to their efficacy, safety and less side effects. Teucrium genus is a member of the Lamiaceae family, which medicinal plant have been in traditional medicine, especially wound healing inflammatory conditions. Teucroside, 9′-decarboxyrosmarinic acid-4′-O-α-rhamnosyl-(1‴→6‴)-O-β-galactosyl-(1‴→4″)-O-α-rhamnoside natural phenolic compund isolated identified from genus. In this study, because bioactive properties Teucrioside, it was...
Mesenchymal stem cells (MSCs) can be found in many types of adult tissues such as the bone marrow, adipose, placenta, liver, and periosteum. Recently, adipose tissue-derived MSCs (ADMSCs) have become one most preferred MSC because their fast proliferation rate, abundance, high plasticity for variable cell types. It is known that ADMSCs are able to differentiate into various cells, including osteoblasts, so they quite promising orthopedic clinical trials. The present study aimed compare...
Objective: The present study aimed to obtain the required cells and select a suitable scaffold material for constructing an artificial bladder using tissue engineering approach. 
 Materials methods: convenience of obtaining human adipose tissue-derived stem (hADMSCs) was used in this study. It attempted differentiate these into smooth muscle (SMC), which are along wall bladder. Urothelial were enzymatically isolated from biopsies. Synthetic (poly-lactide co-glycolic acid, PLGA) natural...
Siklopropankarboksilat, merkaptoasetat, trikloroasetat ve 4-dodesilbenzensülfonat anyonları ile trietanolamonyum (TEA) katyonu TEA esaslı tuzların oluşumuna yol açtı. tuzlarının antibakteriyel aktivitesi bazı bakterilere karşı incelendi elde edilen sonuçlar minimum inhibitör konsantrasyon (MİK) değerlerinin hesaplanmasında kullanıldı. Ek olarak, antiproliferatif aktiviteleri meme kanseri hücre hattı üzerinde in vitro olarak incelendi. Ayrıca, bu anti-anjiyogenik etkisini değerlendirmek için...
ABSTRACT Objective: This study aimed to compare the in vitro growth-inhibitory effects of commonly used chemotherapeutic combinations folinic acid, 5-fluorouracil, and oxaliplatin (FOLFOX) irinotecan (FOLFIRI) on colon cancer cells (HT29 CaCo-2 cells). Materials Method: The viability HT29 treated with different concentrations FOLFOX FOLFIRI was evaluated using 3-(4,5-dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide assay. percentage cell rates were spectrophotometrically determined...