A5102991204- Urologic and reproductive health conditions
- Spectroscopy Techniques in Biomedical and Chemical Research
- Bladder and Urothelial Cancer Treatments
- Urological Disorders and Treatments
- Renal cell carcinoma treatment
- Urinary and Genital Oncology Studies
- Cancer Immunotherapy and Biomarkers
- Spectroscopy and Chemometric Analyses
- Genital Health and Disease
- Soft tissue tumor case studies
- Testicular diseases and treatments
- Sarcoma Diagnosis and Treatment
- Tumors and Oncological Cases
- Cancer Genomics and Diagnostics
- IgG4-Related and Inflammatory Diseases
- Renal and related cancers
- Breast Lesions and Carcinomas
- Salivary Gland Tumors Diagnosis and Treatment
- Vascular Malformations and Hemangiomas
- Cancer and Skin Lesions
- Histiocytic Disorders and Treatments
- Thermography and Photoacoustic Techniques
- Ovarian cancer diagnosis and treatment
- Molecular Biology Techniques and Applications
- Prostate Cancer Treatment and Research
The Christie NHS Foundation Trust
2010-2022
University of Otago
2019
The Christie Hospital
1998-2016
Cornell University
2014
Manchester Royal Eye Hospital
2006
Manchester Royal Infirmary
2006
University of Ulster
1998-1999
Royal Victoria Hospital
1998-1999
Belfast City Hospital
1999
Royal Preston Hospital
1997
Fourier transform infrared (FTIR) spectroscopy is a vibrational spectroscopic technique that uses radiation to vibrate molecular bonds within the sample absorbs it. As different samples contain or configurations of bonds, FTIR allows us obtain chemical information on molecules sample. microspectroscopy in conjunction with principal component-discriminant function analysis (PC-DFA) algorithm was applied grading prostate cancer (CaP) tissue specimens. The PC-DFA used alongside established...
Transmission and transflection infrared microscopy of biological cells tissue suffer from significant baseline distortions due to scattering effects, predominantly resonant Mie (RMieS). This can also distort peak shapes apparent positions making interpretation difficult often unreliable. A correction algorithm, the extended multiplicative signal (RMieS-EMSC), has been developed that be used remove these distortions. The algorithm two key user defined parameters influence accuracy correction....
Abstract Prostate cancer is the most common gender specific cancer. The current gold standard for diagnosis, histopathology, subjective and limited by variation between different pathologists. diagnostic problems associated with correct grading staging of prostate (CaP) has led to an interest in development spectroscopic based techniques. FTIR microspectroscopy used combination a Principal Component Discriminant Function Analysis (PC‐DFA) was applied investigate histopathology diagnosis CaP....
Infrared spectral histopathology has shown great promise as an important diagnostic tool, with the potential to complement current pathological methods.
At present. a prognosis for prostate cancer (CaP) is determined by its accurate assessment of disease grade and stage. Histopathological typing using the Gleason grading system most universally accepted approach CaP provides an indication as to aggressiveness tumour at time presentation. However, this based upon visual criterion pattern recognition that operator dependent subject intra- inter-observer variability, which can result in inappropriate patient management. Thus, there need...
Abstract Urothelial carcinomas of the bladder are a heterogeneous group tumours, although some histological sub‐variants rare and sparsely reported in literature. Diagnosis from conventional urothelial carcinoma can be challenging, as they may mimic morphology other malignancies or benign tumours therefore their distinction is important. For first time, spectral pathology these has been documented by infrared microspectroscopy an attempt made to profile biochemistry. It important not only...
To determine the outcome of clinically negative node (cN0) patients with penile cancer undergoing dynamic sentinel biopsy (DSNB), comparing results a 1- and 2-day protocol that can be used as minimal invasive procedure for staging cancer.This is retrospective analysis 151 cN0 who underwent DSNB from 2008 to 2013 newly diagnosed cancer. Data were analysed per groin separated into groups according followed. The comparison two protocols involved number nodes excised, γ-counts, false-negative...
The prostate cancer (PCa) diagnostic pathway is undergoing a radical change with the introduction of multiparametric magnetic resonance imaging (mpMRI), genomic testing, and different biopsy techniques. It has been proposed that these tests should be used in sequential manner to optimise risk stratification.
Small cell (neuroendocrine) carcinoma of the urinary bladder is clinically more aggressive than urothelial (transitional cell) carcinoma. We have investigated immunohistochemical markers most useful in diagnosing small bladder.We evaluated expression chromogranin A, CD44 variant 6 (CD44v6), cytokeratin (CAM 5.2), gamma-enolase, synaptophysin, and CD45 46 carcinomas bladder. were mixed 21 (46%) cases. The two with best ability to discriminate between A CD44v6. Chromogranin had 97% specificity...
Testicular Leydig cell tumours are rare. Although most behave benignly approximately 10% malignant. Clinicopathological features have been described which some value in predicting malignant behaviour, although as with other endocrine uncertainties remain many individual cases. Our aim was to determine the clinicopathological of 20 testicular tumours. We wished investigate whether, addition established features, MIB1 index and/or flow cytometric analysis nuclear DNA content malignancy. also...
Metastatic renal cancer remains hard to treat and the treatment is generally palliative. However, high-dose interleukin-2 (HD IL-2) produced 5% 10% complete remissions most of these were durable. With advent newer treatments with less toxicity, role HD IL-2 uncertain. We present here a case series 72 patients metastatic given first-line IL-2. From 2003 2006, offered irrespective their histologic features (retrospective cohort). 2006 2008, was only after stratification into risk groups based...
Objective To assess the role of centralized pathological review in penile cancer management. Materials and Methods Newly diagnosed squamous cell carcinomas (SCC) penis, including carcinoma situ ( CIS ), from biopsy specimens were referred 15 centres to regional supra‐network multidisciplinary team S n‐ MDT ) between 1 J anuary 2008 30 M arch 2011. Biopsy histology reports slides respective referring hospitals reviewed by pathologists. The specimens’ histological type, grade stage reported...
FTIR chemical imaging has been demonstrated as a promising technique to construct automated systems complement histopathological evaluation of biomedical tissue samples. The rapid large areas previously limiting factor in this application. Consequently, smaller have had be sampled, possibly introducing sampling bias and potentially missing diagnostically important areas. In report high spatial resolution image whole prostate cross section is shown comprising 66 million pixels. Each pixel...
<h3>Background</h3> VEGF-targeted therapy has become the mainstay of treatment for majority mRCC patients. For most patients, benefit is short-lived and therefore remains palliative in intent. HD IL2 an effective immunotherapy capable durable remission some patients but its unselected use been difficult due to modest response rate considerable adverse effects. Using set pathology criteria as a selection tool clinical practice, we have able show improved outcomes our previous report. Here,...
Fourier transform infrared (FT-IR) chemical imaging has been demonstrated as a promising technique to complement histopathological assessment of biomedical tissue samples. Current histopathology practice involves preparing thin sections and staining them using hematoxylin eosin (H&E) after which histopathologist manually assess the architecture under visible microscope. Studies have shown that there is disagreement between operators viewing same suggesting complementary for verification...
<h3>Background:</h3> Dairy consumption in childhood may have long-term effects on cardiovascular mortality through influencing the development of risk factors or programming effects. <h3>Objective:</h3> To investigate whether dairy and calcium is associated with adult due to coronary heart disease (CHD), stroke all causes. <h3>Methods:</h3> In 1937–9, 4999 children England Scotland participated a study family food consumption, assessed from 7-day household inventories. Cause death was...