A5051889975- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Graphene and Nanomaterials Applications
- Advanced biosensing and bioanalysis techniques
- Carbon and Quantum Dots Applications
- MicroRNA in disease regulation
- Dendrimers and Hyperbranched Polymers
- Advanced Drug Delivery Systems
- RNA Interference and Gene Delivery
- Autophagy in Disease and Therapy
- Antimicrobial Peptides and Activities
- Nanocluster Synthesis and Applications
- Polydiacetylene-based materials and applications
- Biosensors and Analytical Detection
- Extracellular vesicles in disease
- Gold and Silver Nanoparticles Synthesis and Applications
- Analytical Chemistry and Chromatography
- Advanced Nanomaterials in Catalysis
- Graphene research and applications
- Lanthanide and Transition Metal Complexes
- Electrochemical sensors and biosensors
- Advanced Chemical Sensor Technologies
- Advanced Polymer Synthesis and Characterization
- Polymer Surface Interaction Studies
- Chemical Synthesis and Analysis
Tabriz University of Medical Sciences
2017-2024
Maastricht University
2021
University of Tehran
2009-2016
Tarbiat Modares University
2013-2016
Faculty (United Kingdom)
2016
Atomic Energy Organization of Iran
2006
In recent years, the role of optically sensitive nanomaterials has become powerful moieties in therapeutic techniques and particularly emphasized. Currently, by extraordinary development different fields medicine, they have found new applications. Phototherapy modalities, such as photothermal therapy (PTT) toxic heat generation photodynamic (PDT) reactive oxygen species, are known promising phototherapeutic techniques, which can overcome limitations conventional protocols. Moreover,...
Heteroatom-doped carbon dots (CDs) with optical absorbance in the near-infrared (NIR) region can provide an opportunity for selective cancer photothermal therapy (PTT). Here, eco-friendly, simple, cost-efficient, and one-step hydrothermal method was developed to synthesize copper-doped CDs (Cu-doped CDs). The Alcea extract as source combined CuSO4 dopant. Microscopic spectroscopic analyses showed that spherical monodisperse Cu-doped (Cu-dCDs) sizes below 10 nm have bright fluorescence...
The aim of this study is to develop a nano graphene–polyglycerol–curcumin hybrid capable simultaneous co-delivery chemotherapeutic drug and cytotoxic heat cancer cells by near infrared (NIR) laser irradiation.
Abstract Background Combination chemo-photothermal therapy appears to be one of the next generations cancer treatment. In this study hollow gold nanostars (HGNSs) and nanocages (GNCs) were synthesized stabilized with thermo-pH-sensitive thiol-end capped ABC triblock copolymer poly(acrylic acid)-b-poly( N isopropylacrylamide)-b-poly (e-caprolactone)-SH; PAA-b-PNIPAAm-b-PCL-SH (GNSs@Pol). Doxorubicin (Dox) was conjugated GNSs@Pol nanostructures via ionic interaction, covalent attachment...
The formation of protein corona (PC) around nanoparticles (NPs) has been reported inside biological conditions. This effect can alter delivery capacity toward the targeted tissues. Here, we synthesized folic acid-modified chitosan NPs (FA-CS NPs) using different concentrations acid (5, 10, and 20%). FA-CS were exposed to plasmas breast cancer patients healthy donors evaluate possibility PC formation. We also monitored uptake efficiency in vitro conditions after incubation with human cell...
MicroRNAs (miRNAs) play a crucial role in regulating adaptive and maladaptive responses cardiovascular diseases, making them attractive targets for potential biomarkers. However, their as novel biomarkers diagnosing diseases requires systematic evaluation.In this study, we aimed to identify key set of miRNA using integrated bioinformatics machine learning analysis. We combined analyzed three gene expression datasets from the Gene Expression Omnibus (GEO) database, which contains peripheral...
Numerous infections are linked to Pseudomonas aeruginosa. It is one of the major medical concerns because virulence and antibiotic resistance. Antibiotic encapsulation in liposomes a good strategy for controlling caused by this microorganism. Evaluation anti-Pseudomonas aeruginosa effect liposomal form Imipenem/Cilastatin vitro condition. By using disk agar diffusion technique, isolates' pattern resistance was identified. The placed into nanoliposome after it had been made thin layer ethanol...
Exosomal damage-associated molecular patterns can play a key role in immunostimulation and changing the cold tumor microenvironment to hot.
A hyperbranched-linear-hyperbranched amphiphile (HLHA) consisting of polyglycerol, polycaprolactone and polycitric acid blocks was synthesized characterized. The self-assembly HLHA in aqueous solutions produced nearly monodispersed nanoparticles. average size the nanoparticles 120 nm. Spectroscopy microscopy analysis showed that change their structure response to changes polarity medium solution state, so hydrophobicity or hydrophilicity solvent dominates properties This property used load...
Since albumin is the main transporter and most abundant protein in blood, interactions between this drug/gene nanocarriers are of great importance to ensure successful delivery target tissue(s) body.
Abstract Here, we investigated the photothermal effect of gold nanorods (GNRs) on human neuroblastoma CD133 + cancer stem cells (CSCs) via autophagic cell death. GNRs were synthesized using Cetyltrimethylammonium bromide (CTAB), covered with bovine serum albumin (BSA). CSCs enriched from magnetic-activated sorting (MACS) technique. Cells incubated coated BSA and exposed to 808-nm near-infrared laser irradiation for 8 min yield low (43 °C), medium (46 high (49 °C) temperatures. After 24 h,...
Abstract Background Cancer stem cells (CSCs) are of great diagnostic importance due to their involvement in tumorigenesis, therapeutic resistance, metastasis and relapse. Method In this work, a sensitive electrochemical cytosensor was successfully established detect HT-29 colorectal cancer based on nanocomposite composed mesoporous silica nanoparticles (MSNs) platinum (PtNPs) using simple fast electrodeposition technique glassy carbon electrode (GCE). Results According SEM images, the PtNPs...