Katia George
A5032517655- Monoclonal and Polyclonal Antibodies Research
- SARS-CoV-2 and COVID-19 Research
- Complement system in diseases
- Receptor Mechanisms and Signaling
- T-cell and B-cell Immunology
- vaccines and immunoinformatics approaches
- Neuroscience and Neuropharmacology Research
- Ion channel regulation and function
- Protein purification and stability
The University of Texas at Austin
2020-2022
Rockefeller University
2019
The molecular composition and binding epitopes of the immunoglobulin G (IgG) antibodies that circulate in blood plasma after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are unknown. Proteomic deconvolution IgG repertoire to spike glycoprotein convalescent subjects revealed response is directed predominantly (>80%) against residing outside receptor domain (RBD). In one subject, just four lineages accounted for 93.5% response, including an amino (N)-terminal...
SUMMARY Although humoral immunity is essential for control of SARS-CoV-2, the molecular composition, binding epitopes and effector functions immunoglobulin G (IgG) antibodies that circulate in blood plasma following infection are unknown. Proteomic deconvolution circulating IgG repertoire (Ig-Seq 1 ) to spike ectodomain (S-ECD 2 four convalescent study subjects revealed response oligoclonal directed predominantly (>80%) S-ECD lie outside receptor domain (RBD). When comparing either RBD,...
The behavioral response to antidepressants is closely associated with physiological changes in the function of neurons hippocampal dentate gyrus (DG). Parvalbumin interneurons are a major class GABAergic neurons, essential for DG function, and involved pathophysiology several neuropsychiatric disorders. However, little known about role(s) these depressive disorder or mediating delayed antidepressants. Here we show, mice, that parvalbumin express functionally silent serotonin 5A receptors,...