Solutions of N-chlorotaurine (NCT) are effective microbiocidal agents with a broad spectrum pharmacological activity and outstanding tolerability. The main problem limiting their medical use is instability, which generally inherent in solutions all chlorine-active compounds. In this work, we developed new synthetic approach to the synthesis such solutions, consists activation granular fibrous polymeric materials immobilized N-chlorosulfonamide groups, act here as chlorinating agent. It was...

Active chlorine compounds are powerful microbicidal agents traditionally used for surface disinfection. Following the COVID-19 pandemic, potential use of these air treatment to mitigate spread infectious diseases has been actively studied. A promising approach involves developing disinfection systems capable maintaining a sufficient concentration most effective gaseous antimicrobial component active –hypochlorous acid (HOCl) – in indoor air. This study investigates influence various factors...

Hypochlorous acid HOCl is an effective disinfectant with a broad spectrum and high rate of microbicidal action. Its use for air treatment can be tool the prevention therapy infectious diseases. In this work, in vivo study was conducted on 110 Wistar Han rats (12 72 weeks old) effect single inhalation containing gaseous activity antioxidant system enzymes. For this, special installation designed to uniformly maintain concentration regulate it over wide range. Inhalation exposure carried out 4...

Virucidal properties of N-chlorosulfonamides immobilized on fibrous styrene-divinylbenzene copolymers have been studied. Corresponding materials with different functional group structures and chlorine content synthesized FIBAN polymer carriers in the form staple fibers non-woven fabrics. The study has conducted general accordance EN 14476 standard poliovirus type-1 adenovirus type-5. It found that all tested samples exhibit pronounced virucidal activity: regardless carrier form, sodium...

The aim of the work was to evaluate antimicrobial activity polymeric materials with immobilized N-Chlorosulfonamide groups against multidrug-resistant hospital strains common microorganisms and determine resistance microbial penetration these materials.
 Materials methods: studied samples were copolymers styrene divinylbenzene in form staple fibre non-woven fabric immobilized
 various structures. Hospital have been isolated from clinical material; their antibiotic sensitivity has...

Objective The objective was to determine the inhalation toxicity of electrochemically generated sodium hypochlorite solution after its single administration laboratory animals in form a highly dispersed aerosol.Materials and methods study has been conducted according OECD Test Guideline №403 'Acute Inhalation Toxicity.' Laboratory were exposed an aerosol containing 1.7 ± 0.13 mg/m3 active chlorine. hematological biochemical parameters blood experimental have determined, as well specific...

Abstract Polymer materials with immobilized functional groups–donors of active chlorine are widely used to create products a microbiocidal effect and increased resistance microbial contamination. In this work, various methods for the synthesis granular styrene–divinylbenzene polymers N ‐chlorosulfonamide groups were investigated. It has been shown that chlorine‐active SO 2 NNaCl from non‐functionalized polymer matrix through stage its sulfochlorination chlorosulfonic acid in dichloromethane...

-chlorotaurine (NCT) is a broad-spectrum antimicrobial agent with outstanding tolerability, effective for topical and inhalation use. This paper presents the results of studies single repeated intravenous infusions NCT to laboratory animals. The were conducted on female Wistar Han rats. effect general condition, behavioral reactions, main biochemical hematological parameters, hemocoagulation system, cardiovascular condition internal organs was studied. It found that do not reveal deviations...

Abstract BACKGROUND The synthesis of sodium hypochlorite (NaClO) by classical electrolysis NaCl solutions on a Ti/Pt anode is characterized parallel formation undesirable chlorate (NaClO 3 ) impurities. Oxidation to with high current efficiency (CE) realized the oxidized, passivated Pt surface. On surface reduced cathodic polarization, NaClO can be CE close 90% almost without accumulation. Long‐term leads passivation RESULTS Electrolysis while periodically changing polarity electrodes...

A method has been developed for the synthesis of granular polymeric materials with immobilized N-chloro-sulfonamide groups. Commercially available resin polymers widely applied preparation ion exchangers have used as polymer carriers. The elaborated technological conditions make it possible to modify these resins a high conversion degree, without deteriorating strength characteristics, and possibility regulating concentration active chlorine over wide range (up 11 % w/w). structure...

Abstract BACKGROUND The synthesis of sodium hypochlorite solutions by electrolysis low‐concentration and isotonic NaCl using the most available dimensionally stable anodes from platinized titanium is promising point view economics process. However, such seriously complicated formation toxic chlorate impurity. RESULTS It shown that in under anodic polarization, platinum surface rapidly passes into an oxidized passive state with a NaClO current efficiency (CE) less than 30% CE 3 more 20%....

The search for new effective means combating pathogenic microorganisms is one of the most important tasks modern medicine. main reason need such studies obvious tendency to increase resistance compounds used these purposes, observed over past few decades. Leading international organizations recognize problem evolution «superbacteria» as a global threat humanity. Compounds active chlorine are extremely biocidal agents. However, number reasons, classic chlorine-active drugs (solutions sodium...

The energy and electronic parameters of the nitrogen inversion in imines Н 2 С=NХН n (ХН = СН 3 , NH OH, F, SiH PH SH, Cl) have been calculated with DFT method (B3LYP 6-311+G(d,p)) terms natural bond orbital. It has established that interactions lone pair (LP) orbitals at imino carbon atom are practically independent X contribute to decrease barriers (Δ Е і ≠ ). While nN®σ * X–H nN«σ nN«nX substantially depend on heteroatom type promote increase Δ values rise electronegativity atom....

Treatment of styrene-divinylbenzene sulfonated cation exchangers with a small amount thionyl chloride prior to reaction chlorosulfonic acid significantly facilitates the production sulfochlorides from polymeric sulfonic acids and their salts. Polymeric were synthesized by sequential treatment gel macroporous in Na H forms acid. Transformation these into sulfamides via ammonia, followed gaseous chlorine, yielded sodium N-chlorosulfonamides an active chlorine content exceeding 15%....

The disinfection of air in premises, especially the presence people, is an important element system for prevention infectious diseases. A promising solution this to fill premises with antimicrobial chemical agent that would quickly neutralize pathogens directly at moment they enter air. It advisable use hypochlorous acid HOCl as such agent. But traditional methods administering into by aerosolizing its solutions may be accompanied a number risks can prevented using gaseous HOCl. Therefore,...

The development and creation of non-toxic dressing materials exhibiting pronounced antimicrobial effect accelerating wound-healing process without increasing pathogenic microorganisms drug resistance is an actual task modern medicine.Aim. Evaluation toxicological characteristics a material containing 6 % 9 active chlorine in single application on the skin as well study epithelization rate uninfected wound surface determination its healing activity vivo model S. aureus ATCC 6538-infected...

Annotation. Polymeric materials with immobilized active groups are widely used in medicine. Some of them have pronounced antimicrobial properties and, to a certain extent, alternatives antibiotics. The aim this research is study the new polymeric groups-donors chlorine and oxygen. Polymers FIBAN brand form staple fiber non-woven fabric, which convenient for manufacture dressings, been as carriers. A special technology has developed chemical grafting N-chlorosulfonamide peroxycarboxylic...

The increase in the frequency and scale of epidemics infectious diseases gives extreme urgency to development new technologies for antiseptic disinfectant treatment various media, as well materials/reagents their implementation. Antimicrobial polymer materials chemical structures, including those containing halogen-active functional groups, are promising this regard. This work is devoted synthesis investigation properties granular fibrous with immobilized N-bromosulfonamide groups different...

Introduction: Microorganisms colonizing the surface of dental implants can form biofilms that protect their microcolonies from mechanical impact, antimicrobial compounds, and immune factors. Prophylactic use antibiotics during implantation exert selective pressure on development resistance. In this context, N-chlorotaurine (NCT) is a promising compound to combat resistant agents. The aim investigate efficacy NCT against pathogens associated with implant complications. Materials methods. A...

Electrodes made of platinized titanium with a surface platinum content 2–3 mg/cm2 can be used in non-diaphragm flow- and accumulative-type electrolyzers for the electrolysis low-concentrated NaCl solutions order to obtain pure NaClO solutions. If 0.15 M solution is carried out on electrodes usual mode at current densities 20–40 mA/cm2, then anode passes into an oxidized passive state. In this case, efficiency hypochlorite does not exceed 40%, chlorate more than 20%. During short...

Chronic myelomonocytic leukosis (CMML) is rarely diagnosed and amounts to 1 per 100 thousand of adults year, more often in men over 60 years. The clinical case the rare, prolonged course myelodysplastic chronic (MD-CMML) a middle-aged woman with rapid transformation into acute monocytic leukemia (AMoL-M5в) atypical fulminant presented. A retrospective analysis disease drew attention severe vasculitis suffered by patient 19 years ago, which could be regarded as debut CML presence...