Solutions of N-chlorotaurine (NCT) are effective microbiocidal agents with a broad spectrum pharmacological activity and outstanding tolerability. The main problem limiting their medical use is instability, which generally inherent in solutions all chlorine-active compounds. In this work, we developed new synthetic approach to the synthesis such solutions, consists activation granular fibrous polymeric materials immobilized N-chlorosulfonamide groups, act here as chlorinating agent. It was...

Virucidal properties of N-chlorosulfonamides immobilized on fibrous styrene-divinylbenzene copolymers have been studied. Corresponding materials with different functional group structures and chlorine content synthesized FIBAN polymer carriers in the form staple fibers non-woven fabrics. The study has conducted general accordance EN 14476 standard poliovirus type-1 adenovirus type-5. It found that all tested samples exhibit pronounced virucidal activity: regardless carrier form, sodium...

Abstract Polymer materials with immobilized functional groups–donors of active chlorine are widely used to create products a microbiocidal effect and increased resistance microbial contamination. In this work, various methods for the synthesis granular styrene–divinylbenzene polymers N ‐chlorosulfonamide groups were investigated. It has been shown that chlorine‐active SO 2 NNaCl from non‐functionalized polymer matrix through stage its sulfochlorination chlorosulfonic acid in dichloromethane...

The efficiency of cold rolling steel strip in the main depends on quality technological lubricant and its cost. In this regard, it is important to develop new compositions effective metalworking coolants that are low cost provide maximum reduction friction coefficient. We developed tested basis vegetable oil chicken fat. were Donbas State Engineering Academy (DSEA) a laboratory mill, 100 × 100, 08Kp steel. was determined by stretch ratio λ coefficient μ deformation zone, which found forward...

Aim. To synthesize immobilized N-chloro-N-alkylsulfonamides with different lengths alkyl radicals, to study their properties and emission of active chlorine from them upon activation.Methods. Immobilized N-alkylsulfonamides were synthesized by reaction on a styrene-divinylbenzene copolymer (8 % divinylbenzene) sulfochloride amines, e.g.: Methylamine, Ethylamine, n-Propylamine, n-Butylamine, Cyclohexylamine, n-Dodecylamine. obtained after Sodium hypochlorite. Active the substances into...

The efficiency of cold sheet and strip rolling steels non-ferrous metals in the main depends on quality technological lubricant its cost. In this regard, it is important to develop new compositions effective metal-working coolants (MWC) having low cost providing maximum reduction friction coefficient. We developed tested MWC basis chicken fat, mono- diglycerides their esters boric acid synthesized from wastes sunflower oil production. were DSEA laboratory mill 100x100 with a roll diameter...

Aim. Determination of the antibacterial and antifungal action fibrous forms N,N-dichloro sulfonamides immobilized on styrene divinylbenzene copolymer.Materials methods. The non-woven form sulfonamide was used as an object for research. active chlorine content in sample 16 %, thickness – 2.5 mm, surface density 340 g/m2.The material determined using modified "agar plate" method beef-extract agar (BEA). main wound infection pathogens, e.g.: E. coli (АТСС 25922), S. aureus 6538), C. albicans...

There are two following processes in the solutions of N-carbamoyl-1,4-benzoquinone monoimines: Z,E-isomerization with respect to C=N bond and hindered rotation around –NH–C(O)– bond, which can be registered by 1H NMR spectroscopy. The experimental values activation energy these (G298) were determined as 67.21 62.05 kJ/mol, respectively. Z,E-Isomerization was found run under inversion mechanism. theoretical barriers 3,5-dimethyl- 2,6-dimethyl-N-carbamoyl-1,4-benzoquinone monoimines...

Treatment of styrene-divinylbenzene sulfonated cation exchangers with a small amount thionyl chloride prior to reaction chlorosulfonic acid significantly facilitates the production sulfochlorides from polymeric sulfonic acids and their salts. Polymeric were synthesized by sequential treatment gel macroporous in Na H forms acid. Transformation these into sulfamides via ammonia, followed gaseous chlorine, yielded sodium N-chlorosulfonamides an active chlorine content exceeding 15%....

The development and creation of non-toxic dressing materials exhibiting pronounced antimicrobial effect accelerating wound-healing process without increasing pathogenic microorganisms drug resistance is an actual task modern medicine.Aim. Evaluation toxicological characteristics a material containing 6 % 9 active chlorine in single application on the skin as well study epithelization rate uninfected wound surface determination its healing activity vivo model S. aureus ATCC 6538-infected...

Issues of discovery and development antiseptics disinfectants are engaged in the world. Requirements for medication severely limit range chemical compounds that can be used as an active start disinfectants. Chlorinated (bleach, chloramine, hypochlorite) traditional The emission chlorine from immobilized sodium N-chlorosulfonamides was studied stability resulting solutions evaluated. For microbiological tests, non-woven samples N-chlorosulfonamide were provided on a copolymer styrene with...

Мета роботи. У сучасних умовах іммобілізація лікарських засобів на полімерних носіях набуває все більшого значення, що пов’язане з вимогами до зменшення токсичності та пролонгації дії препаратів. Відома сульфаніламідних препаратів стиромалі, метакрилатних матрицях, де фармакологічно активний сульфаніламід легко вивільняється полімеру при застосуванні, в результаті кислотного гідролізу. Разом тим спостерігається, іммобілізовані сульфаніламіди, отримані основі амінометильованого співполімеру...

Mono- and di- esters of adipinic acid with long chain ethoxylated aliphatic alcohols (mixture C10 – C12 C16 C18 alkohols) were obtained by the reaction Synthanol DS-10 its dichloroanhydride. If p-toluenesulfonic as catalyst used acylating agent mole ratio to is 1:1 yield monoacylated product was 76 %. (temperature 120-125 °C, 3 h). 2:1 diacylated 80 % 6 Using dichloroanhydride gives 90 90-100 7.5 h) product. The structure all compounds established IR NMR spectroscopy. Surface tension...

Annotation. Polymeric materials with immobilized active groups are widely used in medicine. Some of them have pronounced antimicrobial properties and, to a certain extent, alternatives antibiotics. The aim this research is study the new polymeric groups-donors chlorine and oxygen. Polymers FIBAN brand form staple fiber non-woven fabric, which convenient for manufacture dressings, been as carriers. A special technology has developed chemical grafting N-chlorosulfonamide peroxycarboxylic...

The reactions between quinone arenalazines or their chlorine derivatives and ammonia were investigated.It was shown that these lead to the formation of amidrazones 1,4-benzoquinone.The optimal preparative conditions for this reaction determined.The scheme involves 1,8-addition similar addition mono-, dialkylamines arylamines described earlier.The direct product instantly undergoes oxidation by air oxygen cannot be separated in a pure form.The yields synthesized depend on oxidation-reduction...