A5089990483- Gut microbiota and health
- Diet and metabolism studies
- Barrier Structure and Function Studies
- Regulation of Appetite and Obesity
- Dietary Effects on Health
- Adipose Tissue and Metabolism
- Microbial Metabolites in Food Biotechnology
- Clostridium difficile and Clostridium perfringens research
- Reproductive biology and impacts on aquatic species
- Exercise and Physiological Responses
- Environmental Toxicology and Ecotoxicology
- Neurological Disease Mechanisms and Treatments
- Epigenetics and DNA Methylation
- Agricultural and Food Sciences
- Wnt/β-catenin signaling in development and cancer
- Fatty Acid Research and Health
- Aquaculture disease management and microbiota
- Adipokines, Inflammation, and Metabolic Diseases
- Diet, Metabolism, and Disease
- Pancreatic function and diabetes
- Biochemical effects in animals
- Digestive system and related health
- COVID-19 Clinical Research Studies
- Aquaculture Nutrition and Growth
- Nutrition and Health in Aging
Universidade Estadual de Campinas (UNICAMP)
2016-2024
In this study, we investigated the effect of diet supplementation with sodium butyrate (5% w/w), a short-chain fatty acid produced by intestinal microbiota, on metabolic parameters, body adiposity, hepatic and pancreatic lipid accumulation, beta cell function/mass as well structure function tight junction-mediated epithelial barrier in both normal obese/prediabetic C57 mice fed regular (control) or high-fat for 60 days, respectively. Butyrate treatment significantly inhibited all...
Abstract Background The continuous proliferation of intestinal stem cells followed by their tightly regulated differentiation to epithelial is essential for the maintenance gut barrier and its functions. How these processes are tuned diet microbiome an important, but poorly understood question. Dietary soluble fibers, such as inulin, known ability impact bacterial community epithelium, consumption has been usually associated with health improvement in mice humans. In this study, we tested...
Hyperbaric oxygen (HBO) therapy is a well-established method for improving tissue oxygenation and typically used the treatment of various inflammatory conditions, including infectious diseases. However, its effect on intestinal mucosa, microenvironment known to be physiologically hypoxic, remains unclear. Here, we demonstrated that daily with hyperbaric affects gut microbiome composition, worsening antibiotic-induced dysbiosis. Accordingly, HBO-treated mice were more susceptible...
Hypothalamic interleukin-6 (IL6) exerts a broad metabolic control. Here, we demonstrated that IL6 activates the ERK1/2 pathway in ventromedial hypothalamus (VMH), stimulating AMPK/ACC signaling and fatty acid oxidation mouse skeletal muscle. Bioinformatics analysis revealed hypothalamic IL6/ERK1/2 axis is closely associated with oxidation– mitochondrial-related genes muscle of isogenic BXD strains humans. We showed requires α2-adrenergic to modify metabolism. To address physiological...
Aim:The aim of this work was to evaluate the sensitivity Pacu fingerlings (Piaractus mesopotamicus) by measuring effects median lethal concentration (LC 50 ) atrazine (ATZ -28.58 mg/L) after acute exposure (up 96 h). Materials and Methods:The fish were exposed LC ATZ for h (28.58 in a static system.During experiment, randomly distributed four glass tanks (50 L) containing dechlorinated water.Four control group, ATZ-exposed group (n=4 per tank), given total number 16 animals tested group.The...
Abstract Leiarius marmoratus , a freshwater catfish from Pimelodidae family, shows great biological and commercial relevance because of its geographic distribution adaptation to fish‐farm. The knowledge the morphological characteristics digestive tract is fundamental understanding fish physiology nutrition, which helps in planning diets provide better management success farming. Thus, this work described morphology histochemistry L. adults. After euthanasia, animals were dissected for...
Abstract Wnt proteins act mainly as paracrine signals regulating cell proliferation and differentiation. The canonical pathway has recently been associated with pancreas development the onset of type 2 diabetes in rodent human but underlying mechanisms are still unclear. aim this work was threefold: (a) to screen for expressed by murine pancreas/islet cells, (b) investigate whether gene expression profile can be changed hyperplastic islets from prediabetic mice (fed a high‐fat diet), (c)...
Clinical and experimental data indicate that severe acute respiratory syndrome coronavirus (SARS-CoV)-2 infection is associated with significant changes in the composition function of intestinal microbiota. However, relevance these effects for SARS-CoV-2 pathophysiology unknown. In this study, we analyzed impact microbiota depletion after antibiotic treatment on clinical immunological responses K18-hACE2 mice to infection. Mice were treated a combination antibiotics (kanamycin, gentamicin,...
A diabetes melito tipo 2 é uma síndrome endócrino-metabólica caracterizada pela hiperglicemia associada à resistência periférica insulina.É conhecido que, em um estado pré-diabético, a célula beta pancreática apresenta resposta adaptativa compensatória, podendo sofrer hiperplasia e hipertrofia.Estudos tem demonstrado efeito antidiabetogênico do butirato de sódio quando associado dieta hiperlípidica
Background: Tissue/cellular action of butyrate on energy metabolism and intestinal barrier at normal metabolic conditions or the prediabetes are still unclear. In this work, we investigated beneficial effect dietary supplementation with sodium metabolism, body mass composition, epithelial mediated by tight junction (TJ) in chow diet-fed high-fat diet (HF)-fed prediabetic mice, considering well-known as an epigenetic inflammatory regulator.Methods/Results: Butyrate reduced fat/lean ratio,...