A5025061958- Adipose Tissue and Metabolism
- Regulation of Appetite and Obesity
- Adipokines, Inflammation, and Metabolic Diseases
- Diet and metabolism studies
- Muscle metabolism and nutrition
- Exercise and Physiological Responses
- Liver Disease Diagnosis and Treatment
- Pancreatic function and diabetes
- Physical Education and Gymnastics
- Diet, Metabolism, and Disease
- Circadian rhythm and melatonin
- Sphingolipid Metabolism and Signaling
- Fibroblast Growth Factor Research
- Endoplasmic Reticulum Stress and Disease
- PI3K/AKT/mTOR signaling in cancer
- Medical research and treatments
- Metabolism, Diabetes, and Cancer
- Erythrocyte Function and Pathophysiology
- Healthcare Regulation
- Ubiquitin and proteasome pathways
- Single-cell and spatial transcriptomics
- Genetics, Aging, and Longevity in Model Organisms
- Biochemical Analysis and Sensing Techniques
- Genetic Syndromes and Imprinting
- Biochemical effects in animals
Universidade Estadual de Campinas (UNICAMP)
2015-2023
Universidade Estadual Paulista (Unesp)
2015
Abstract The aim of this study was to compare the effects aerobic, strength, and combined training on metabolic disorders induced by a fructose-rich diet. Wistar rats (120 days old) were randomized into five groups (n = 8–14): C (control diet sedentary), F (fed FA subject aerobic exercise), FS strength FAS exercises). After 8-week experiment, glucose homeostasis, blood biochemistry, tissue triglycerides, inflammation evaluated analyzed. protocol exerted greater insulin sensitivity, liver...
Non-alcoholic fatty liver disease (NAFLD) has a positive correlation with obesity, insulin resistance and type 2 diabetes mellitus (T2D). The aerobic training is an important tool in combating NAFLD. However, no studies have demonstrated the molecular effects of short-term strength on accumulation hepatic fat obese mice. This study aimed to investigate mechanisms oxidation lipid synthesis short duration protocol was used avoid changing amount adipose tissue. Swiss mice were separated into...
BackgroundThe Iroquois homeobox 3 (Irx3) gene has been identified as a functional long-range target of obesity-associated variants within the fat mass and protein (FTO) gene. It is highly expressed in hypothalamus, both whole-body knockout hypothalamic restricted abrogation its expression results lean phenotype, which mostly explained by resulting increased energy expenditure brown adipose tissue. Because potential implication pathogenesis obesity, we evaluated cell distribution Irx3...
Obesity is one of the leading noncommunicable diseases in world. Despite intense efforts to develop strategies prevent and treat obesity, its prevalence continues rise worldwide. A recent study has shown that tricarboxylic acid intermediate succinate increases body energy expenditure by promoting brown adipose tissue thermogenesis through activation uncoupling protein-1; this generated interest surrounding potential usefulness as an approach obesity. It currently unknown how impacts protein...
Glucose uptake is an important phenomenon for cell homeostasis and organism health. Under resting conditions, skeletal muscle dependent on insulin to promote glucose uptake.Insulin, after binding its membrane receptor, triggers a cascade of intracellular reactions culminating in activation the transporter 4, GLUT4, among other outcomes.This migrates plasma assists internalization.However, under special conditions such as physical exercise, alterations levels molecules ATP calcium actto...
Hypothalamic interleukin-6 (IL6) exerts a broad metabolic control. Here, we demonstrated that IL6 activates the ERK1/2 pathway in ventromedial hypothalamus (VMH), stimulating AMPK/ACC signaling and fatty acid oxidation mouse skeletal muscle. Bioinformatics analysis revealed hypothalamic IL6/ERK1/2 axis is closely associated with oxidation– mitochondrial-related genes muscle of isogenic BXD strains humans. We showed requires α2-adrenergic to modify metabolism. To address physiological...
The present study evaluated the effects of exercise training on pyruvate carboxylase protein (PCB) levels in hepatic tissue and glucose homeostasis control obese mice. Swiss mice were distributed into three groups: (CTL), fed a standard rodent chow; diet-induced obesity (DIO), an obesity-inducing diet; third group, which also received diet, but was subjected to protocol (DIO + EXE). Protocol carried out for 1 h/d, 5 d/wk, 8 weeks, performed at intensity 60% exhaustion velocity. An insulin...
Nescient helix-loop-helix 2 (NHLH2) is a hypothalamic transcription factor that controls the expression of prohormone convertase 1/3, therefore having an impact on processing proopiomelanocortin and thus energy homeostasis. Studies have shown KO Nhlh2 results in increased body mass, reduced physical activity, hypogonadism. In humans, polymorphism NHLH2 gene associated with obesity; Prader-Willi syndrome, condition characterized by obesity, hypogonadism behavioral abnormalities, reduced....
Hypothalamic sphingosine‐1‐phosphate receptor 1 (S1PR1), the G protein–coupled of sphingosine‐1‐phosphate, has been described as a modulator in control energy homeostasis rodents. However, this mechanism is still unclear. Here, we evaluate role interleukin 6 (IL‐6) associated with acute physical exercise hypothalamic S1PR1–signal transducer and activator transcription 3 (STAT3) axis. Acute session an intracerebroventricular IL‐6 injection increased S1PR1 protein content STAT3 phosphorylation...
The mitochondrial unfolded protein response (UPRmt) is an adaptive cellular to stress ensure proteostasis and function. Here we explore the capacity of physical exercise induce UPRmt in skeletal muscle. Therefore, combined mouse models (swimming treadmill running), pharmacological intervention, bioinformatics analyses. Firstly, RNA sequencing Western blotting analysis revealed that acute aerobic session stimulated several mitostress-related genes content muscle, including markers....
In experimental obesity, the hypothalamus is affected by an inflammatory response activated dietary saturated fats. This inflammation triggered as early one day after exposure to a high-fat diet, and during its progression, there recruitment of cells from systemic circulation. The objective present study was identifying chemokines potentially involved in development hypothalamic diet-induced inflammation. order identify this process, we performed real-time PCR array that determined Ackr2...
Abstract Obesity and aging lead to abnormal transforming growth factor‐β1 (TGF‐β1) signaling in the hypothalamus, triggering imbalance on glucose metabolism energy homeostasis. Here, we determine effect of acute exercise TGF‐β1 expression hypothalamus two models obesity mice. The bioinformatics analysis was performed evaluate correlation between hypothalamic Tgf‐β1 messenger RNA (mRNA) genes related thermogenesis brown adipose tissue (BAT) by using a large panel isogenic BXD Thereafter,...
É de grande importância a investigação dos efeitos do exercício para saúde metabólica quando realizado no início da vida, e quais seriam as respostas durante fase adulta. O objetivo desse estudo é analisar os físico intensidade moderada infância na adiposidade sensibilidade à insulina ratos Vinte Wistar desmamados 28 dias vida foram divididos em grupos Controle Treinado. grupo permaneceu sedentário, enquanto o Treinado realizou natação 80% limiar anaeróbio (determinado pelo teste lactato...
Background: The hypothalamic proopiomelanocortin (Pomc) neurons act as first-order sensors of systemic energy stores, providing signals that regulate caloric intake and expenditure. In experimental obesity, dietary saturated fatty acids affect Pomc endopeptidases (PCs), resulting in the abnormal production neurotransmitters α-melanocyte-stimulating hormone (α-MSH) β-endorphin, thus impacting balance. cAMP response element-binding protein (CREB) is one transcription factors control expression...
Abstract Obesity is a worldwide health problem and directly associated with insulin resistance type 2 diabetes. The liver an important organ for the control of healthy glycemic levels, since in this reduces phosphorylation forkhead box protein 1 (FOXO1) protein, leading to higher hepatic glucose production (HGP) fasting hyperglycemia. Aerobic physical training known as strategy increasing action by FOXO1 reducing gluconeogenesis. However, little about effects strength context. This study...
Introduction: Chronic migraine (CM) is a common neurological disorder with global prevalence range of about 2%. There evidence that anodal motor transcranial direct current stimulation (tDCS) might be promising adjuvant intervention in CM. This randomized controlled trial (RCT) aims to evaluate the efficacy tDCS reducing episodes CM patients on standard prophylactic medication. Research hypothesis: tDCS, as an add-on treatment, reduce frequency adults when compared treatment alone....
The SIRT1 deacetylase protein plays a crucial role in cellular metabolism. It is known that during aging decreases activity can contributes to development of metabolic disorders. PURPOSE: Determine if the reduction iNOS genetically (knockout) or by exercise related increased S-nitrosation and/or post-translational mechanisms responsible for this phenomenon. METHOD: “Young” (Y) (2 months), “sedentary-old” (O) (30 mo) “trained old” (TO) and “iNOS KO (iNOSKO) groups were submitted treadmill...
Investigate the effects of different protocols physical training (PT) on insulin sensibility (IS) and Akt phosphorylation (p-Akt) in skeletal muscle obese rats.Animals were distributed four groups according to diet training: Control: received standard chow (C); Sedentary obese: high fat (HFD) for 12 weeks (OS); Obese Trained 1: HFD PT without overload 6 (OT-1); 2: with 5% body weight (OT-2).Insulin tolerance test was used evaluate IS.Western blotting performed p-Akt total gastrocnemius...