A5090009348- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Metabolism, Diabetes, and Cancer
- Exercise and Physiological Responses
- Regulation of Appetite and Obesity
- Diet and metabolism studies
- Endoplasmic Reticulum Stress and Disease
- PI3K/AKT/mTOR signaling in cancer
- Liver Disease Diagnosis and Treatment
- Mitochondrial Function and Pathology
- Muscle metabolism and nutrition
- Autophagy in Disease and Therapy
- Fatty Acid Research and Health
- Advanced Breast Cancer Therapies
- FOXO transcription factor regulation
- Pancreatic function and diabetes
- Sirtuins and Resveratrol in Medicine
- Genetics, Aging, and Longevity in Model Organisms
- Protein Tyrosine Phosphatases
- Dietary Effects on Health
- Protein Kinase Regulation and GTPase Signaling
- Diet, Metabolism, and Disease
- Cancer, Hypoxia, and Metabolism
- Circadian rhythm and melatonin
- Lipid metabolism and biosynthesis
Universidade Estadual de Campinas (UNICAMP)
2016-2025
Ministry of Science, Technology and Innovation
2025
Hospital de Clínicas da Unicamp
2009-2024
Instituto Nacional de Ciência e Tecnologia de Obesidade e Diabetes
2022
École Polytechnique Fédérale de Lausanne
2014-2016
657 Oslo
2016
Universidade Estadual Paulista (Unesp)
2015
Fundação de Amparo à Pesquisa do Estado de São Paulo
2007
Adult stem cells (SCs) are essential for tissue maintenance and regeneration yet susceptible to senescence during aging. We demonstrate the importance of amount oxidized form cellular nicotinamide adenine dinucleotide (NAD(+)) its effect on mitochondrial activity as a pivotal switch modulate muscle SC (MuSC) senescence. Treatment with NAD(+) precursor riboside (NR) induced unfolded protein response synthesis prohibitin proteins, this rejuvenated MuSCs in aged mice. NR also prevented MuSC mdx...
With no approved pharmacological treatment, nonalcoholic fatty liver disease (NAFLD) is now the most common cause of chronic in Western countries and its worldwide prevalence continues to increase along with growing obesity epidemic. Here, we show that a high‐fat high‐sucrose (HFHS) diet, eliciting hepatosteatosis resembling human liver, lowers hepatic nicotinamide adenine dinucleotide (NAD + ) levels driving reductions mitochondrial content, function, adenosine triphosphate (ATP) levels,...
Overnutrition caused by overeating is associated with insulin and leptin resistance through IKKbeta activation endoplasmic reticulum (ER) stress in the hypothalamus. Here we show that physical exercise suppresses hyperphagia hypothalamic IKKbeta/NF-kappaB a mechanism dependent upon pro-inflammatory cytokine interleukin (IL)-6. The disruption of hypothalamic-specific IL-6 action blocked beneficial effects on re-balance food intake resistance. This molecular mechanism, mediated activity,...
Metformin is a widely used antidiabetic drug whose anticancer effects, mediated by the activation of AMP-activated protein kinase (AMPK) and reduction mTOR signaling, have become noteworthy. Chemotherapy produces genotoxic stress induces p53 activity, which can cross-talk with AMPK/mTOR pathway. Herein, we investigate whether combination metformin paclitaxel has an effect in cancer cell lines.Human tumors were xenografted into severe combined immunodeficient (SCID) mice lines treated only or...
Environmental factors and host genetics interact to control the gut microbiota, which may have a role in development of obesity insulin resistance. TLR2-deficient mice, under germ-free conditions, are protected from diet-induced It is possible that presence microbiota could reverse phenotype an animal, inducing resistance animal genetically determined increased sensitivity, such as TLR2 KO mice. In present study, we investigated influence on metabolic parameters, glucose tolerance, signaling...
Prolonged exercise of medium to high intensity is known promote a substantial effect on the energy balance rats. In male rats, moderately severely intense programs lead reduction in food intake. However, exact causes for appetite-suppressive effects are not known. Here, we show that intracerebroventricular insulin or leptin infusion reduced intake exercised rats greater extent than observed control animals. Exercise was associated with markedly increased phosphorylation/activity several...
Insulin resistance in diet-induced obesity (DIO) is associated with a chronic systemic low-grade inflammation, and Toll-like receptor 4 (TLR4) plays an important role the link among insulin resistance, obesity. The current study aimed to analyze effect of exercise on TLR4 expression activation obese rats its consequences sensitivity signaling.
Recent preclinical studies showed the potential of nicotinamide adenine dinucleotide (NAD+) precursors to increase oxidative phosphorylation and improve metabolic health, but human data are lacking. We hypothesize that nicotinic acid derivative acipimox, an NAD+ precursor, would directly affect mitochondrial function independent reductions in nonesterified fatty (NEFA) concentrations. In a multicenter randomized crossover trial, 21 patients with type 2 diabetes (age 57.7 ± 1.1 years, BMI...
Subclinical systemic inflammation is a hallmark of obesity and insulin resistance. The results obtained from number experimental studies suggest that targeting different components the inflammatory machinery may result in improvement metabolic phenotype. Unsaturated fatty acids exert antiinflammatory activity through several distinct mechanisms. Here, we tested capacity ω3 ω9 acids, directly their food matrix, to G protein-coupled receptor (GPR)120 GPR40 pathways. GPR120 was activated liver,...
β-Hydroxy-β-methylbutyrate (HMβ) supplementation is used to treat cancer, sepsis and exercise-induced muscle damage. However, its effects on animal human health the consequences of this treatment in other tissues (e.g., fat liver) have not been examined. The purpose study was evaluate HMβ skeletal hypertrophy expression proteins involved insulin signalling. Rats were treated with (320 mg/kg body weight) or saline for one month. signalling evaluated by western blotting, hormonal...
Early evidence demonstrates that exogenous nitric oxide (NO) and the NO produced by inducible synthase (iNOS) can induce insulin resistance. Here, we investigated whether this resistance, mediated S ‐nitrosation of proteins involved in early steps signal transduction pathway, could be reversed acute physical exercise. Rats on a high‐fat diet were subjected to swimming for two 3 h‐long bouts, separated 45 min rest period. Two or 16 h after exercise protocol rats killed from signalling pathway...
Recent characterization of the ability uncoupling protein 2 (UCP2) to reduce ATP production and inhibit insulin secretion by pancreatic beta-cells has placed this mitochondrial as a candidate target for therapeutics in diabetes mellitus. In present study we evaluate effects short-term treatment two animal models type mellitus with an antisense oligonucleotide UCP2. both models, Swiss mice (made obese diabetic hyperlipidic diet) ob/ob mice, resulted significant improvement hyperglycemic...
TNFα is an important mediator of catabolism in cachexia. Most its effects have been characterized peripheral tissues, such as skeletal muscle and fat. However, by acting directly the hypothalamus, can activate thermogenesis modulate food intake. Here we show that high concentration hypothalamus leads to increased O2 consumption/CO2 production, body temperature, reduced caloric intake, resulting loss mass. thermogenic response produced β3-adrenergic signaling brown adipose tissue (BAT),...
Accumulating evidence has demonstrated that S-nitrosation of proteins plays a critical role in several human diseases. Here, we explored the inducible nitric oxide synthase (iNOS) involved early steps insulin-signaling pathway and insulin resistance skeletal muscle aged mice. Aging increased iNOS expression major signaling, thereby reducing sensitivity muscle. Conversely, iNOS-null mice were protected from S-nitrosation-induced resistance. Moreover, pharmacological treatment with an...
Hepatic insulin resistance is the major contributor to fasting hyperglycemia in type 2 diabetes. The protein kinase Akt plays a central role suppression of gluconeogenesis involving forkhead box O1 (Foxo1) and peroxisome proliferator-activated receptor gamma co-activator 1 alpha (PGC-1α), control glycogen synthesis synthase beta (GSK3β) liver. It has been demonstrated that endosomal adaptor APPL1 interacts with blocks association its endogenous inhibitor, tribbles-related 3 (TRB3), improving...