A5015045887- Adipose Tissue and Metabolism
- Mitochondrial Function and Pathology
- Autophagy in Disease and Therapy
- Cardiovascular and exercise physiology
- Muscle metabolism and nutrition
- Heart Rate Variability and Autonomic Control
- Sports Performance and Training
- Metabolism, Diabetes, and Cancer
- Physical Activity and Health
- Lipid metabolism and biosynthesis
- Genetics and Physical Performance
- Diet and metabolism studies
- Renal and Vascular Pathologies
- Pancreatic function and diabetes
- Infective Endocarditis Diagnosis and Management
- Sirtuins and Resveratrol in Medicine
- PI3K/AKT/mTOR signaling in cancer
- Endoplasmic Reticulum Stress and Disease
- Biochemical Acid Research Studies
- Cardiac Health and Mental Health
- Adipokines, Inflammation, and Metabolic Diseases
- Aortic Thrombus and Embolism
- Sphingolipid Metabolism and Signaling
- Lipid metabolism and disorders
- Lysosomal Storage Disorders Research
Universidade Estadual de Campinas (UNICAMP)
2015-2022
Anhanguera (Brazil)
2022
University of Lisbon
1967
The impairment of the mitochondrial functions is a hallmark aging. During aging, there downregulation two mechanisms strictly associated with integrity, including mitonuclear imbalance (eg, in mitochondrial- versus nuclear-encoded proteins) and unfolded protein response (UPRmt). Here, we evaluated effects aerobic exercise UPRmt markers skeletal muscle old mice. We combined physiological tests, molecular bioinformatic analyzes to evaluate 4 weeks training on young (2 months) aged (24 C57BL/6J...
This study investigated the effect of non-periodized training performed at 80, 100 and 120% anaerobic threshold intensity (AnT) a linear periodized model adapted for swimming rats on gene expression monocarboxylate transporters 1 4 (MCT1 4, in soleus gastrocnemius muscles), protein contents, blood biomarkers, tissue glycogen, body mass, aerobic capacities. Sixty Wistar were randomly divided into 6 groups (n = 10 per group): baseline (BL; euthanized before period), control group (GC; not...
The main objective of this study was to examine the effect continuous aerobic training (CAT) in hypertensive, obese people. Seven patients average age (45.3±3.9 years), height (1.63±0.1 m), body weight (89.09±22.0 kg), and mass index (33.44±8.6 kg/m2) were subjected training. CAT performed thrice-weekly nonconsecutive sessions (90 min per week) with intervals 48 hr between each session. entailed 30 walking at an intensity 70%â80% maximum heart rate (MHR) on a treadmill over period...
Embolism has been considered a rare cause of coronary occlusion and thought by some authors (Shrader, Bawell, Moragues, 1956) to be almost invariably fatal.The first well-documented case diagnosed during life was reported Mussafia (1948).Further cases were subsequently Cordeiro Dias Coelho (1951), Glushien, Reiter, Fischer (1952), Cheng, Cahill, Foley (1953).In all but the last, origin emboli bacterial endocarditis.In except (1948), which survived at least year, there necropsy proof.Oakley,...
This study aimed to investigate the effect of an acute exercise bout performed on intensities below, at and above anaerobic threshold (but same total workload) over muscle liver glycogen stores.For that, after determination by lactate minimum test, rats were divided in six groups: GC, G90, G100, G110 G120 (control exercised 90, 100, 110 120% threshold).Rats euthanized immediately (0h) four hours bout.The results demonstrated significant depletion when is high (G110 G120).Also, despite only...
Dysfunction of the adipose tissue metabolism is considered as a significant hallmark aging. It has been proposed that α-β hydrolase domain containing 5 (ABHD5) plays critical role in control lipolysis. However, ABHD5 lipolysis during aging or exercise unknown. Here we combined experimental mouse model with transcriptomic analyzes by using murine and human databases to explore response exercise. Transcriptomic data revealed downregulation Abhd5 messenger RNA levels subcutaneous white (scWAT)...
High volume or high intensity exercises promotes different metabolic responses. However, the effects of isoload acute at manipulations and on parameters muscle damage markers in rats are unknown. PURPOSE:To determine efforts accomplished (near anaerobic threshold) swimming rats. Specifically, to verify responses serum (glucose [GL], triglycerides [TG], density lipoprotein [HDL], total protein [TP], albumin [AL], uric acid [UA], creatine-kinase [CK]) glycogen content gastrocnemius (GAG)...
PURPOSE: The hypothalamus controls the energy homeostasis integrating of hormonal and nutritional signals. In this context, glucose plays a critical role in control balance acting specific hypothalamic neurons. It has been demonstrated that lost selective sensibility neurons are related to hyperphagia obesity. Recently, hypoxia-inducible factor 2 alpha (HIF2α) have emerged as regulated important maintenance neuronal HIF2α function can be considerate determinate strategy for lean phenotype....
Here we sought to determine the effect of S1P administration on physical performance and AMPK Akt phosphorylation in muscle mice.Methods: Mice were divided four groups: Wild-Type, Placebo, Exercise plus intramuscular during 3 consecutive days.Thereafter, animals performed an incremental exercise test.Results: We demonstrate a relation between response markers mitochondrial biogenesis.Immunoblotting analysis showed increase AKT administration.The placebo group ran significantly less...
We previously reported evidence about the positive effects of continuous aerobic training (CAT) in hypertensive obese people. showed that 90 min/week exercise on a treadmill (70%-80% Maximal Heart Rate [MHR]) was able to improve systemic blood metabolism subjects. Therefore, we believe reducing recommended amount (150 min/week) by American College Sports Medicine (ACSM) is valuable strategy for sedentary individuals with pathological conditions, since suggested protocol easyto- perform, fast...
A lipólise é um mecanismo biológico complexo responsável por promover a degradação de moléculas gordura para obtenção substrato energético. O processo envelhecimento acompanhado pelo aumento do acúmulo tecido adiposo, que ocorre ao menos em parte, devido redução da capacidade ativação lipólise. Por outro lado, sabidamente o exercício físico reconhecido como potente estimulador Recentemente, proteína ABHD5 (do inglês, ?-? hidrolase domain-contain protein 5) foi descrita molécula chave no...