A5028539524- Bone Tissue Engineering Materials
- Advanced Fiber Optic Sensors
- Spectroscopy and Chemometric Analyses
- Advanced Chemical Sensor Technologies
- Periodontal Regeneration and Treatments
- Analytical Chemistry and Sensors
- Photonic and Optical Devices
- Additive Manufacturing and 3D Printing Technologies
- Water Quality Monitoring and Analysis
- 3D Printing in Biomedical Research
- Dental Implant Techniques and Outcomes
- Shoulder Injury and Treatment
- Tracheal and airway disorders
- Reproductive Biology and Fertility
- Tendon Structure and Treatment
- Orthopaedic implants and arthroplasty
- Airway Management and Intubation Techniques
- Facial Trauma and Fracture Management
- Anatomy and Medical Technology
- Underwater Vehicles and Communication Systems
- Dental materials and restorations
- Ovarian function and disorders
- Reconstructive Facial Surgery Techniques
- Sports injuries and prevention
- Shoulder and Clavicle Injuries
University of Michigan
2015-2024
University of California, San Francisco
2022-2023
Kaiser Permanente
2022
Kaiser Permanente San Francisco Medical Center
2022
Michigan United
2009
University of Limerick
1992-2008
Newport (United States)
2004
University of Pennsylvania
2000-2003
University of Minnesota
2003
Orthopaedic Research Laboratories
1998
Structured Abstract: Authors – Hollister SJ, Lin CY, Saito E, Schek RD, Taboas JM, Williams Partee B, Flanagan CL, Diggs A, Wilke EN, Van Lenthe GH, Müller R, Wirtz T, Das S, Feinberg SE, Krebsbach PH Objective To develop an integrated approach for engineering craniofacial scaffolds and to demonstrate that these engineered would have mechanical properties in the range of tissue support bone regeneration reconstruction. Experimental Variable Scaffold architecture designed achieve desired...
Rotator cuff tears are one of the most common causes pain and disability in upper extremity. With use an animal model, we studied healing response a controlled defect normal supraspinatus tendon with reduced intrinsic capacity. In 36 Sprague-Dawley rats, defects (2 mm x 2 mm) were created tendons bilaterally. To model intrinsically capacity to heal, tissue adjacent area left shoulder was treated situ freezing. The contralateral not frozen. After 3 (n = 12), 6 12 12) weeks, animals killed...
To determine the potential of an integrated, image-based computer-aided design (CAD) and 3-dimensional (3D) printing approach to engineer scaffolds for head neck cartilaginous reconstruction auricular nasal reconstruction.
Scaffold design incorporating multiscale cues for clinically relevant, aligned tissue regeneration has potential to improve structural and functional integrity of multitissue interfaces. The objective this preclinical study is develop poly(ε‐caprolactone) (PCL) scaffolds with mesoscale microscale architectural specific human ligament progenitor cells assess their ability form bone–ligament–cementum complexes in vivo. PCL are designed integrate a 3D printed bone region micropatterned thin...
In the oral and craniofacial complex, tooth loss is most commonly acquired disfiguring injury. Among formidable challenges of reconstructing tooth-supporting osseous defects in cavity regeneration functional multi-tissue complexes involving bone, ligament, cementum. Furthermore, periodontal engineering with spatiotemporal orientation ligament (PDL) remains challenging obstacle for restoration physiological loading homeostasis. We report on ability a hybrid computer-designed...
The study demonstrates use of a novel intervention for severe tracheobronchomalacia (TBM).OBJECTIVE To test novel, 3-dimensionally (3D) printed, bioresorbable airway splint efficacy in extending survival porcine model severe, life-threatening TBM.DESIGN AND PARTICIPANTS A randomized, prospective animal trial was used to evaluate an external as treatment TBM multi-institutional, multidisciplinary collaboration between biomedical engineering department and academic surgery center.Six...
An in vivo animal model was used to evaluate overuse and plus intrinsic tendon injury or extrinsic compression the development of rotator cuff injury. Forty-four male Sprague-Dawley rats were divided into groups 22. Each left shoulder received an (treadmill running), each right only overuse. Eleven from group sacrificed at 4 8 weeks. Supraspinatus tendons evaluated histologically geometrically biomechanically. Ten constituted a cage-activity control group. Both supraspinatus experimental had...
Abstract Introduction Tissue engineering provides an alternative modality allowing for decreased morbidity of donor site grafting and rejection less compatible alloplastic tissues. Methods Using image‐based design computer software, a precisely sized shaped scaffold osseous tissue regeneration can be created via selective laser sintering. Polycaprolactone has been used to create condylar ramus unit (CRU) application in temporomandibular joint reconstruction Yucatan minipig animal model....
Objectives/Hypothesis To report the clinical safety and efficacy of three‐dimensional (3D)–printed, patient‐specific, bioresorbable airway splints in a cohort critically ill children with severe tracheobronchomalacia. Study Design Case series. Methods From 2012 to 2018, 15 subjects received 29 on their trachea, right and/or left mainstem bronchi. The median age at implantation was 8 months (range, 3–25 months). Nine were female. Five had history extracorporeal membrane oxygenation (ECMO), 11...
Despite significant advances in 3D biomaterial printing, the potential of printing for patient specific implants and tissue reconstruction has not been fully exploited. This is due part to lack integration image-based design with within a relevant regulatory framework, namely control, required by FDA. In this manuscript, we describe image-based, multi-scale control framework clinical translation. Specifically, define inputs scaffolds, utilize achieve these inputs. We then illustrate...
It has been remarked above that the difference between sick- ling and non-sickling children is particularly marked at about this level of parasitaemia.It important to notice for natural selection operate in favour hetero- 7ygouLs sicklers it must exert its effect before reproductive age; view advanced here can only absence acquired immunity, an endemic area precisely those below age who lack effective immunity.All evidence course indirect * decisive information-accurate mortality statistics...
The aim of this research is to develop, demonstrate and characterize techniques for fabricating such scaffolds by combining solid freeform fabrication computational design methods. When fully developed, are expected enable the tissue engineering endowed with functionally graded material composition porosity exhibiting sharp or smooth gradients. Results bio‐compatibility in vivo implantation presented.