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V-M. Leino

ORCID: 0000-0001-8534-3720
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A5097629008
Research Areas
  • Bone fractures and treatments
  • Orthopaedic implants and arthroplasty
  • Bone Tissue Engineering Materials

University of Helsinki
 2021

 S53P4 bioactive glass scaffolds induce BMP expression and integrative bone formation in a critical-sized diaphysis defect treated with a single-staged induced membrane technique
OPENALEX - Publications 
Elof Eriksson Robert Björkenheim Gustav Strömberg Mari Ainola Peter Uppstu and 5 more Laura Aalto‐Setälä V-M. Leino Leena Hupa Jarkko Pajarinen Nina Lindfors

Critical-sized diaphysis defects are complicated by inherent sub-optimal healing conditions. The two-staged induced membrane technique has been used to treat these challenging since the 1980's. It involves temporary implantation of a membrane-inducing spacer and subsequent bone graft defect filling. A single-staged, graft-independent would reduce both socio-economic costs patient morbidity. Our aim was enable such single-staged approach through development strong bioactive glass scaffold...

10.1016/j.actbio.2021.03.035 article EN cc-by-nc-nd Acta Biomaterialia 2021-03-25
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