A5067946811- Bone Tissue Engineering Materials
- Orthopaedic implants and arthroplasty
- Dental materials and restorations
- Dental Implant Techniques and Outcomes
- biodegradable polymer synthesis and properties
- Bone fractures and treatments
- Additive Manufacturing and 3D Printing Technologies
- Spine and Intervertebral Disc Pathology
- Electrospun Nanofibers in Biomedical Applications
- Knee injuries and reconstruction techniques
- Research in Social Sciences
- Facial Trauma and Fracture Management
- Advanced Cellulose Research Studies
- Innovative Microfluidic and Catalytic Techniques Innovation
- Nanocomposite Films for Food Packaging
- Magnesium Alloys: Properties and Applications
- Nanoplatforms for cancer theranostics
Åbo Akademi University
2015-2024
Critical-sized diaphysis defects are complicated by inherent sub-optimal healing conditions. The two-staged induced membrane technique has been used to treat these challenging since the 1980's. It involves temporary implantation of a membrane-inducing spacer and subsequent bone graft defect filling. A single-staged, graft-independent would reduce both socio-economic costs patient morbidity. Our aim was enable such single-staged approach through development strong bioactive glass scaffold...
Abstract The present study focuses on enhancing the thermomechanical properties of poly(methyl methacrylate) (PMMA), a transparent and biocompatible polymer known for its high strength but limited toughness. approach involves development PMMA/cellulose nanocrystals (CNCs) composites. To improve interfacial compatibility between PMMA CNCs, two‐step process is employed. Initially, CNCs undergo oxidation using sodium periodate, followed by introduction amino groups through reductive amination....
Abstract The two‐stage induced‐membrane (IM) technique is increasingly used for treatment of large bone defects. In stage one, the defect filled with polymethylmethacrylate (PMMA), which induces a membrane around implant. two, PMMA replaced graft. Bioactive glasses (BAGs) are substitutes bone‐stimulating and angiogenic properties. We have previously shown that certain type BAG can also induce foreign‐body similar to PMMA. aim this study was evaluate bone‐forming capacity sintered BAG‐S53P4...
The silicate-based bioactive glass S53P4 is clinically used in bone regenerative applications granule form. However, utilization of the scaffold form has been limited by high tendency to crystallize during sintering. Here, careful optimization sintering parameters enabled manufacture porous amorphous scaffolds with a strength enough for surgical procedures (5 MPa). Sintering was conducted laboratory furnace times ranging from 25 300 min at 630 °C, i.e., narrowly below commencement...
Bioactive glasses (BAG) are used as bone-graft substitutes in orthopaedic surgery. A specific BAG scaffold was developed by sintering BAG-S53P4 granules. It is hypothesised that this can be a bone substitute to fill defects and induce bioactive membrane (IM) around the defect site. Beyond providing increased mechanical strength, initial inflammatory reaction subsequent IM formation enhanced coating scaffolds with poly(DL-lactide-co-glycolide) (PLGA) also hypothesised. To study...
Deep osteochondral defects may leave voids in the subchondral bone, increasing risk of joint structure collapse. To ensure a stable foundation for cartilage repair, bone grafts can be used filling these defects. Poly(lactide-co-glycolide) (PLGA) is biodegradable material that improves healing and supports matrix deposition. We compared reparative capacity two investigative macroporous PLGA-based biomaterials with commercially available graft substitutes bony part an intra-articular defect...
Abstract We studied how in vitro reactions affect long-term biochemical and mechanical properties of porous tissue engineering scaffolds based on two bioactive glasses accordingly their potential suitability for treating critical-size load-bearing bone defects. Granules glass S53P4 S59 were used to sinter the scaffolds. The sintering variables mechanically durable initially selected according thermal behaviour during heating. further divided into following three groups: uncoated scaffolds,...
Abstract The mechanical properties of polylactide stereocomplexes (PLA SC) have been primarily studied through tensile testing, with inconsistent results, and the compressive PLA SC compared to homocrystalline or amorphous remain poorly understood. In this study, we coated porous bioactive glass 13–93 scaffolds amorphous, homocrystalline, stereocomplex investigate their degradation before after immersion in simulated body fluid. had interconnected pores an average porosity 76%. coatings,...
ABSTRACT Magnesium is important for both bone growth and cartilage formation. However, the postoperative intake of antibiotics such as quinolones may cause a reduction in magnesium levels tissue. The addition to scaffolds therefore be beneficial regeneration osteochondral defects. In this study, porous composite were produced by gas foaming poly( d , l ‐lactide‐co‐glycolide) (PLGA) rods with magnesium‐containing bioresorbable glasses hydroxide fillers. vitro hydrolytical degradation Tris...
Fabrication of porous tissue-engineering scaffolds from bioactive glasses (BAG) is complicated by the tendency BAG compositions to crystallize in thermal treatments during scaffold manufacture. Here, experimental biocompatible glass S59 (SiO
Antimicrobial resistance (AMR) poses a significant risk to public health by rendering the treatment of infectious diseases challenging or potentially unfeasible.The World Health Organization (WHO) listed AMR as one top 10 global threats owing to:➢ Misuse and overuse antimicrobial drugs, ➢ Difficult-to-treat biofilm-forming bacteria, Slow response pharmaceutical companies in developing new antimicrobials drugs.Thus, alternative approaches are urgently sought combat AMR.Our Centre Excellence...