A5090577024- biodegradable polymer synthesis and properties
- Bone Tissue Engineering Materials
- Synthesis and Biological Evaluation
- Synthesis and Characterization of Heterocyclic Compounds
- Nanocomposite Films for Food Packaging
- Natural Fiber Reinforced Composites
- Synthesis and Reactivity of Heterocycles
- Crystallization and Solubility Studies
- Orthopaedic implants and arthroplasty
- 3D Printing in Biomedical Research
- X-ray Diffraction in Crystallography
- Silicone and Siloxane Chemistry
- Advanced Cellulose Research Studies
- Polymer Nanocomposites and Properties
- Microplastics and Plastic Pollution
- Herpesvirus Infections and Treatments
- Asymmetric Hydrogenation and Catalysis
- Crystallography and molecular interactions
- Phenothiazines and Benzothiazines Synthesis and Activities
- Nanoparticle-Based Drug Delivery
- Asymmetric Synthesis and Catalysis
- Synthetic Organic Chemistry Methods
- Chemical Synthesis and Reactions
- Catalytic Cross-Coupling Reactions
- Surface Chemistry and Catalysis
Åbo Akademi University
2011-2021
Borealis (Finland)
2003
University of Szeged
1997
University of Turku
1997
Association of British Orchestras
1990
Wellcome Trust
1981
St Helier Hospital
1977-1978
Twenty patients undergoing allogeneic bone marrow transplantation and 39 receiving remission induction chemotherapy for acute leukaemia were entered into a double blind, placebo controlled stratified trial of acyclovir prophylaxis against herpes group virus infections. Within the transplant intravenous 5 mg/kg twice daily given throughout period granulocytopenia completely prevented oropharyngeal simplex infection compared with 50% incidence in arm (p = 0.033). The also had fewer days fever...
Abstract Aqueous solubility of an active pharmaceutical ingredient (API) is a determining factor that has direct impact on formulation strategies and overall bioavailability. Fabrication nanoemulsions poorly soluble drugs one the widely utilized approaches to overcome this problem. However, thermodynamic instability tedious manufacturing processes limit their clinical translation. Therefore, study was focused circumventing abovementioned hurdles by utilizing polymer as oil phase, instead...
Polymers from natural resources are attracting much attention in various fields including drug delivery as green alternatives to fossil fuel based polymers. In this quest, novel block copolymers on renewable poly(δ-decalactone) (PDL) were evaluated for their capabilities and compared with a polymer i.e. methoxy-poly(ethylene glycol)-b-poly(ε-caprolactone) (mPEG-b-PCL). Using curcumin hydrophobic model, micelles of PDL different orientation AB (mPEG-b-PDL), ABA (PDL-b-PEG-b-PDL), ABC...
Mesoporous silica nanoparticles (MSNs) find tremendous applications in drug delivery due to several advantages such as their easy fabrication process, high loading, biodegradability, biocompatibility, and so forth. Nevertheless, despite advantages, the use of this striking carrier is restricted premature release owing porous structure. Coating pores using polymers has emerged a great solution problem. Polymer coatings, which act gatekeepers, avoid loaded content from MSNs offers opportunity...
Abstract Instances of synthetic polymers obtained from renewable feedstock with the possibility post‐synthesis functionalization are scarce. Herein, first ever synthesis and drug delivery application amphiphilic block copolymer (mPEG‐b‐PJL) derived jasmine lactone free allyl groups on backbone is presented. The polymer synthesized via facile ring‐opening polymerization subsequently, UV mediated thiol‐ene click chemistry utilized for post‐functionalization. introduction hydroxyl, carboxyl,...
Immense work has been conducted in the field of thermoresponsive polymers specifically lower critical solution temperature (LCST) type, but upper (UCST) type remain a significantly unexplored domain.However, recent years, UCST have attracted increased attention as evidenced by rise publications same domain, and therefore, this review is an attempt to compile reported UCST-type polymers.Unlike LCST, are insoluble at low solubilize given solvent increases.The synthesis approaches applications...
The fate of intraperitoneally injected or implanted male rat bone marrow-derived stromal cells inside female sibling host animals was traced using Y-chromosome-sensitive PCR. When intraperitoneally, Y-chromosome-positive were found in all studied organs: heart muscle, lung, thymus, liver, spleen, kidney, skin, and femoral marrow with a few exceptions regardless whether they had gone through osteogenic differentiation not. In the implant experiments, expanded donor seeded on...
Abstract Native potato starch has been modified with allylglycidyl ether (AGE) under various reaction conditions including different sodium hydroxide and AGE concentrations, temperatures times. 1 H‐NMR FT‐IR were used to analyze the products. AGE‐modified starch, two degrees of substitution (DS), namely DS = 1.3 2.3, was synthesized for preparation a new family crosslinked composites reinforced amounts bleached softwood fibres. Composite premixes wood fibres ethylene glycol dimethacrylate...
Native galactoglucomannans (GGMs), which were isolated from thermomechanical pulping waters of Norway spruce, modified through cationization, carboxymethylation, and imination at the reducing end with a primary long-chain hydrocarbon amine. The derivatives tested for their papermaking properties. native GGMs increased wet tensile strength as result dispersion fibrils in fibre web. In wood-containing paper, retention fines extractives without decrease paper strength. also flocculated fillers...
Abstract Polylactides were prepared by ring‐opening polymerization (ROP) in bulk using as catalyst either stannous 2‐ethylhexanoate at a monomer to ratio of 2000, or ferrous acetate (Fe(OAc) 2 ) ratios 500, 1000, 2000 and 3000. The crystallization behaviour was studied for the polymers well degradation both laboratory natural compost environments differential scanning calorimetry, size exclusion chromatography, X‐ray diffractiometry microscopy. No differences apparent due choice amount used,...
Objective of this study was to develope low temperature sol-gel coatings for shape memory metal (NiTi) and evaluate their biocompatibility on NiTi suture material. A series TiO2 TiO2-SiO2 were prepared glass substrates. The silica content ranged from 0 30 mol%. also with polyethyleneglycol (PEG). contact angle photocatalytic activity measurements used the surface properties coatings. Stability tested in simulated body fluid (SBF). 90/10 film made PEG more hydrophilic, showed crack-free after...
ABSTRACT A series of star‐shaped poly( l ‐lactide) (sPLLA) with different branch length was synthesized by ring‐opening polymerization ‐lactide using pentaerythritol as initiator and stannous‐octoate catalyst. The structures properties the sPLLAs were characterized 1 H‐NMR, rheology, differential scanning calorimetry, size‐exclusion chromatography. polymers blended a linear PLLA resin (3051D; NatureWorks) studied for their melt flow thermal properties. Blends containing 10 wt % sPLLA...
Deep osteochondral defects may leave voids in the subchondral bone, increasing risk of joint structure collapse. To ensure a stable foundation for cartilage repair, bone grafts can be used filling these defects. Poly(lactide-co-glycolide) (PLGA) is biodegradable material that improves healing and supports matrix deposition. We compared reparative capacity two investigative macroporous PLGA-based biomaterials with commercially available graft substitutes bony part an intra-articular defect...