A5102915428- Salmonella and Campylobacter epidemiology
- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Biochemical and Molecular Research
- Genomics and Phylogenetic Studies
- Computational Drug Discovery Methods
- Food Safety and Hygiene
- Listeria monocytogenes in Food Safety
- Oral microbiology and periodontitis research
- Vibrio bacteria research studies
- Metal Extraction and Bioleaching
- Data-Driven Disease Surveillance
- Cancer therapeutics and mechanisms
- Meat and Animal Product Quality
- Microbial Natural Products and Biosynthesis
- Marine Sponges and Natural Products
- Neurological diseases and metabolism
- Metabolism and Genetic Disorders
New York City Department of Health and Mental Hygiene
2020-2021
Cornell University
2018-2019
Weill Cornell Medicine
2019
Rutgers, The State University of New Jersey
2010-2013
A wrench in the gears of life Tuberculosis is a global health crisis that threatens to become worse as resistance existing drugs emerges. Identifying ideal targets for drug development requires knowledge weak points biochemical pathways are specific pathogen but absent hosts. Ballinger et al. identified small molecule inhibits enzyme phosphopantetheinyl transferase (PptT), which crucial biosynthesis mycobacterial structural and virulence lipids (see Perspective by Mizrahi Warner). Treatment...
A novel halophilic bacterium of the genus Kangiella was isolated from a marine sponge collected Florida Keys, USA. Strain A79 T , an aerobic, Gram-negative, non-motile, rod-shaped bacterium, grew in 2–15 % (w/v) NaCl, at temperature 10–49 °C and pH 4.5–10. Phylogenetic analysis placed strain family Alcanivoraceae class Gammaproteobacteria . showed 98.5 16S rRNA gene sequence similarity to japonica KMM 3899 96.6 koreensis DSM 16069 95.6 aquimarina 16071 The major cellular fatty acids were...
A Gram-type-negative, obligately anaerobic, selenate-respiring bacterium, strain S4(T), was isolated from activated sludge of a wastewater treatment plant in New Jersey after enrichment with 10 mM selenate as the sole electron acceptor. In addition to its capability, S4(T) also respired arsenate acetate carbon source and donor. Fermentative growth not observed. The optimum temperature 37 °C pH 7. Phylogenetic analysis 16S rRNA gene sequence revealed that is novel member family...
In May 2019, the New York City Department of Health and Mental Hygiene (NYCDOHMH) detected an unusual cluster five salmonellosis patients via automated spatiotemporal analysis notifiable diseases using free SaTScan software (1). Within 1 day detection, graduate student interviewers determined that three had eaten prepared food from same grocery store (establishment A) located inside area. NYCDOHMH initiated investigation to identify additional cases, establish cause, provide control...
New antibiotics are needed to combat rising resistance, with new Mycobacterium tuberculosis (Mtb) drugs of highest priority. Conventional whole-cell and biochemical antibiotic screens have failed. We developed a novel strategy termed PROSPECT (PRimary screening Of Strains Prioritize Expanded Chemistry Targets) in which we screen compounds against pools strains depleted for essential bacterial targets. engineered targeting 474 Mtb genes screened 100-150 activity-enriched unbiased libraries,...