A5063389250- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- DNA Repair Mechanisms
- Metal complexes synthesis and properties
- Synthesis and biological activity
- DNA and Nucleic Acid Chemistry
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Synthesis and Characterization of Heterocyclic Compounds
- Fungal Biology and Applications
- Synthesis and Biological Evaluation
- Medicinal plant effects and applications
- HIV/AIDS drug development and treatment
- Selenium in Biological Systems
- Click Chemistry and Applications
- Quinazolinone synthesis and applications
- Phytochemical compounds biological activities
- Carcinogens and Genotoxicity Assessment
- Vitamin C and Antioxidants Research
- Vitamin K Research Studies
- Multicomponent Synthesis of Heterocycles
- Crystallography and molecular interactions
- Ferrocene Chemistry and Applications
- Synthesis of Organic Compounds
- Metabolism and Genetic Disorders
Medical University of Lodz
2019-2024
Centrum Badań Molekularnych i Makromolekularnych Polskiej Akademii Nauk
2012-2021
Polish Academy of Sciences
2012-2021
University of Łódź
2015-2020
University of Florence
2008
National Institute of Advanced Industrial Science and Technology
2008
A series of nucleobase-modified siRNA duplexes containing “rare” nucleosides, 2-thiouridine (s 2 U), pseudouridine (Ψ), and dihydrouridine (D), were evaluated for their thermodynamic stability gene silencing activity. The with modified units at terminal positions exhibited similar as the nonmodified reference. Introduction s U or Ψ into central part antisense strand resulted in higher melting temperatures (Tm). In contrary, D unit similarly like wobble base pair led to less stable (ΔTm 3.9...
A series of variously functionalized selenium-containing compounds were purposely synthesized and evaluated against a panel cancer cell lines. Most the showed an interesting cytotoxicity profile with compound 5 showing potent activity on MCF7 cells. The ethyl amino derivative acts synergistically cis-platin inhibits GST enzyme potency that well correlates observed in computational analysis suggests possible binding mode enzyme. As main outcome present study, emerged as valid lead for...
Abstract Quaternary ammonium and phosphonium salts have been screened for their toxic effect on HeLa K562 cancer cell lines, as well normal HUVEC cells. Tri‐ n ‐butyl‐ ‐hexadecylphosphonium bromide, the first salt with a halogen anion tested against cells, was 12 times more potent (IC 50 <5 μ M after 24 48 h) than clinically used reference compound cisplatin 17 tri‐ ‐hexyltetradecylphosphonium bis(trifluoromethylsulfonyl)imide, which, to best of our knowledge, is be evaluated in However,...
The results of our previous research indicated that some derivatives benzofurans, particularly halogeno-derivatives, are selectively toxic towards human leukemia cells. Continuing work with this group compounds we here report new data on the synthesis as well regarding physico-chemical and biological characterization fourteen including six brominated compounds. structures all were established by spectroscopic methods (1H- and, 13C-NMR, ESI MS), elemental analyses. Their cytotoxicity was...
Cobalt(<sc>ii</sc>), nickel(<sc>ii</sc>) and copper(<sc>ii</sc>) complexes with thiosemicarbazone-derived ligands exhibiting significant cytotoxic activity against cancer cells were synthesized characterized.
The synthesis of a water-soluble phosphorus-containing dendrimer possessing fluorophore (maleimide-type) linked to the core is described. This found brightly fluorescent in CH2Cl2, but poorly water. cytotoxicity this compound relatively low towards HeLa and A549 cells, less toxic after 48 hours than 24 hours. Association with plasmid DNA (BACE-GFP) analyzed circular dichroism (CD) indicates possible disturbing helical B-type structure DNA. strength association (a "dendriplex") BACE-GFP (also...
Abstract Ionic liquids have attracted considerable interest in various areas as new, nonvolatile and nonflammable organic solvents, catalysts, reaction additives, ligands, drugs, other dedicated materials. exhibit solubility both solvents water. They also constitute very good for many inorganic, organic, organometallic compounds. Yet, the most important feature of ionic is that they provide possibility obtaining substances optimal properties a given process through modification cation...
RNA interference (RNAi) technology provides a powerful molecular tool to reduce an expression of selected genes in eukaryotic cells. Short interfering RNAs (siRNAs) are the effector molecules that trigger RNAi. Here, we describe siRNAs discriminate between wild type and mutant (1174 C→G) alleles human Presenilin1 gene ( PSEN1 ). This mutation, resulting L392V variant, contributes early onset familial Alzheimer′s disease. Using dual fluorescence assay, flow cytometry fluorescent microscopy...
Based on previously identified dicarboximides with significant anticancer and immunomodulatory activities, a series of 26 new derivatives were designed synthesized by the Diels–Alder reaction between appropriate diene maleimide or hydroxymaleimide moieties. The resulting imides functionalized alkanolamine alkylamine side chains subsequently converted to their hydrochlorides. structures obtained compounds confirmed 1H 13C NMR ESI MS spectral analysis. Their cytotoxicity was evaluated in human...
Microtubules are tubular polymers of α/β-tubulin that involved in the maintenance cell shape, motility, and intracellular transport segregation chromosomes during division. dynamic structures, their assembly is regulated by phosphoproteins called microtubule-associated proteins (MAPs). We propose striatin, a protein belonging to striatin family proteins, regulation microtubules. In HEK293T cells, colocalizes with microtubules stably associates PP2Ac. Inhibition expression results...
The clustered DNA lesions (CDLs) are a characteristic feature of ionizing radiation's impact on the human genetic material. CDLs impair efficiency cellular repair machinery, especially base excision (BER). When contain lesion repaired by BER (e.g., apurinic/apyrimidinic (AP) sites) and bulkier 5',8-cyclo-2'-deoxypurine (cdPu), which is not substrate for BER, first one may be affected. cdPus' influence nuclear in xrs5 cells have been investigated using synthetic oligonucleotides with...