A5078466417- Organoselenium and organotellurium chemistry
- Sulfur-Based Synthesis Techniques
- Organic Chemistry Cycloaddition Reactions
- Synthesis and Characterization of Pyrroles
- Chemical Synthesis and Reactions
- Catalytic C–H Functionalization Methods
- Selenium in Biological Systems
- Fluorine in Organic Chemistry
- Synthesis and Catalytic Reactions
- Oxidative Organic Chemistry Reactions
- Asymmetric Synthesis and Catalysis
- Agricultural pest management studies
- Synthesis and Biological Evaluation
- Click Chemistry and Applications
- Synthesis and biological activity
- Cyclopropane Reaction Mechanisms
- Radical Photochemical Reactions
- Sirtuins and Resveratrol in Medicine
- Endoplasmic Reticulum Stress and Disease
- Biochemical Acid Research Studies
- Chemical Reaction Mechanisms
- Antioxidant Activity and Oxidative Stress
- Porphyrin and Phthalocyanine Chemistry
- Viral-associated cancers and disorders
- Autophagy in Disease and Therapy
University of Perugia
2015-2024
Italian Institute of Technology
2022-2023
Green Chemistry
2015-2020
Laboratoire de Synthèse Organique
2020
New York Proton Center
2014
United States Department of Veterans Affairs
1994
A flexible synthesis of spirocyclopropyl oxindoles from vinyl selenones and oxindoles<italic>via</italic>a domino Michael addition/proton transfer/cyclization sequence has been developed.
A series of variously functionalized selenium-containing compounds were purposely synthesized and evaluated against a panel cancer cell lines. Most the showed an interesting cytotoxicity profile with compound 5 showing potent activity on MCF7 cells. The ethyl amino derivative acts synergistically cis-platin inhibits GST enzyme potency that well correlates observed in computational analysis suggests possible binding mode enzyme. As main outcome present study, emerged as valid lead for...
Electrophilic Selenium, Sulfur and Tellurium reagents are widely applied in a number of chemo, regio stereospecific transformations for the installation new functional groups organic electron rich substrates as well synthesis heterocyclic scaffolds. The most recent review articles here currently updated demonstrating continuously growing interest this kind reagents. Keywords: sulfur, tellurium, addition, electrophile, catalysis.
A simple and practical procedure for the oxidation of vinyl selenides into corresponding selenones using Oxone in water at 60 °C has been reported. Structurally diverse phenyl were oxidized under heterogeneous conditions without organic co‐solvents or additional catalysts.
A wide range of 3-selenylindoles were synthesized
Thrombomodulin (TM) is an essential cofactor for the physiologic activation of anticoagulant protein C by thrombin.W e have observed that expression TM mRNA in response to retinoic acid was markedly increased human U937 monoblast-like cells, and MEGO1 megakaryocyte-like but not umbilical vein murine hemangioma K562 erythroblast-like HSD fibroblast-like cells.TM activity cells MEGOl detectable untreated developed rapidly after treatment with acid.In endothelial there minimal change...
A new organocatalytic protocol for the aerobic dehydrogenative allylation of alcohols using non-activated alkenes as allylating reagent and ambient air terminal oxidant is established. Mechanistically, procedure relies on interplay a diselane photoredox catalyst by means light-induced electron transfer process. Under optimized conditions, broad range both cyclic acyclic ethers accessed with very high functional group tolerance excellent regioselectivity.
Display full sizeABSTRACTVinyl selenides, sulfides and tellurides surely represent important compounds in organic chemistry for their relatively easy accessibility synthetic utility. More than the others vinyl selenides showed interesting biological activities such as ability to reduce oxidative stress. New methods synthesis of thioethers have been developed last few years placing a prominent position from an perspective. Tellurides are endowed with unique properties that make them suitable...
An unprecedented Michael/intramolecular etherification cascade reaction of phenyl vinyl selenone with 3‐hydroxyoxindoles under aqueous basic conditions at room temperature is described. The method provides a domino access to new spirooxindole 2,2‐disubstituted oxetanes in moderate good yields mild conditions.
A three-component reaction of secondary α-aminoacids, isatins and vinyl selenones generated spirooxindole-tetrahydropyrrolizines <italic>via</italic> a [3 + 2]-cycloaddition/elimination cascade process.
A novel approach to regioselectively substituted and stereoselectively α-trifluoromethylated tryptamines is reported based on the ene reaction of Boc-protected 3-methyleneindolines with optically pure (R)- or (S)-tert-butanesulfinyltrifluoroacetaldimine. Boc- sulfinylamido-protected α-trifluoromethyltryptamines are obtained in 60-70% yield 85/15 dr by just heating equimolar amounts two partners at 80-90 °C for 2-3 h without a solvent. The absolute configuration amino α-carbon has been...
The autophagy process appears as a promising target for anticancer interventions. Chloroquine (CQ) and its derivative hydroxychloroquine (HCQ) are the only FDA-approved flux inhibitors. Although diverse clinical trials providing encouraging results, several limitations associated with need of high dosage long-term administration these inhibitors also emerging. We showed that inhibition REV-ERB, nuclear receptor regulating circadian rhythm metabolism, enhances CQ-mediated cancer cell death...
Summary The aim of this work was a chemical and biological characterisation Fagiolina del Trasimeno (Italian cowpea landrace) in its coloured white variants. After opening the package (T 0 ), samples were addressed to set assays. Analyses also conducted on cooked, 6‐month‐stored 1 ) commercial products. Chemical composition comparatively analysed by nuclear magnetic resonance (NMR) proton. At both T , raw showed statistically higher values terms phenolic content : 11.51 mg GAE/g, 9.34 GAE/g)...
Oxidation mediated by hydrogen peroxide needs to be accelerate approrpiate catalyst in order completed a reasonable reaction time. As part of our investigation the use organoselenium cataysts bio-mimetic oxidative protocol we reported here some preliminary results on oxidation benzyl alcohol into corresponding benzoic acid.
In the last decades, synthetic methods for construction of carbon-nitrogen bonds rapidly grew, due to important applications amino compounds in fine chemicals, biological and pharmaceutical sciences.The aminoselenylations alkenes alkynes are versatile reactions that usually occur with high regio-and stereo-control under mild reaction conditions.Linear cyclic can be prepared wide functional structural diversity using stoichiometric or catalytic amounts electrophilic selenium reagents.This...
A new protocol for the synthesis of N-vinyl azoles using vinyl selenones and in presence potassium hydroxide was developed. This reaction proceeded under mild transition metal-free conditions through an addition/elimination cascade process. Both aromatic aliphatic various mono-, bi- tri-cyclic can be tolerated give terminal moderate to high yields. plausible mechanism is also proposed.
A new series of indole carboxamides have been synthesized through coupling reactions.Several substitutions on the aromatic ring and amino acids are well tolerated, corresponding obtained with good yields.The same procedure can be also extended to pyrrole nucleus.Four these compounds screened for their antimicrobial activity against ten different yeast strains two them showed an antifungal activity.Further explorations required clarify a potential applicability in biological fields.
For a long time, the main biological activity of selenium derivatives was supposed to be connected their toxicity and some exotic theories correlated historical events poisoning. In 1285, Marco Polo, crossing Shanxi Province Western China, observed an unknown intoxication animals on his ships (loss hair) that later due selenosis in 1860, US Army surgeon documented first poisoning livestock, suggesting fascinating theory horse illness slowed General Custer's Cavalry relief may have been...
The first bench stable selenolates, PhSeZnHalides have been synthesized through a completely atom economy oxidative insertion of the elemental zinc on commercially available PhSeHalides. These reagents showed characteristic nucleophilic reactivity which will be reviewed in this report. All reactions were strongly accelerated when effected water suspension. Alkyl, aryl, vinyl and acyl substitutions, ring-opening epoxides aziridines Michael type addition described including role control...