A5047274015- Organoselenium and organotellurium chemistry
- Synthesis and biological activity
- Sulfur-Based Synthesis Techniques
- Selenium in Biological Systems
- Organometallic Compounds Synthesis and Characterization
- Asymmetric Hydrogenation and Catalysis
- Chemical Synthesis and Reactions
- Chemical Synthesis and Analysis
- Innovative Microfluidic and Catalytic Techniques Innovation
- Molecular spectroscopy and chirality
- Computational Drug Discovery Methods
- Chemical Reactions and Isotopes
- Biochemical effects in animals
- Redox biology and oxidative stress
- Asymmetric Synthesis and Catalysis
- Synthesis and Reactions of Organic Compounds
- Synthesis and Characterization of Pyrroles
- Lysosomal Storage Disorders Research
- Axial and Atropisomeric Chirality Synthesis
- Microwave-Assisted Synthesis and Applications
- Catalytic C–H Functionalization Methods
- Crystal Structures and Properties
- Carcinogens and Genotoxicity Assessment
- Cholinesterase and Neurodegenerative Diseases
- Biochemical Acid Research Studies
University of Perugia
2017-2024
Istituto Nazionale di Fisica Nucleare, Sezione di Firenze
2024
University of Florence
2023-2024
Green Chemistry
2012
The development of new antiviral drugs against SARS-CoV-2 is a valuable long-term strategy to protect the global population from COVID-19 pandemic complementary vaccination. Considering this, viral main protease (Mpro) among most promising molecular targets in light its importance during replication cycle. natural flavonoid quercetin 1 has been recently reported be potent Mpro inhibitor vitro, and we explored effect produced by introduction organoselenium functionalities this scaffold. In...
Abstract A general and efficient method for the selenium‐catalyzed cyclofunctionalization reaction of alkenoic acids alkenols is presented. Hydrogen peroxide was used as green oxidant all products were obtained in very good yields.
Gaucher disease (GD) is a rare genetic metabolic disorder characterized by dysfunction of the lysosomal glycoside hydrolase glucocerebrosidase (GCase) due to mutations in gene GBA1, leading cellular accumulation glucosylceramide (GlcCer). While most current research focuses on primary accumulated material, lesser attention has been paid secondary storage materials and their reciprocal intertwining. By using novel approach based flow cytometry fluorescent labelling, we monitored changes...
A simple, efficient, and selective oxidation under flow conditions of sulfides into their corresponding sulfoxides sulfones is reported herein, using as a catalyst perselenic acid generated in situ by the selenium (IV) oxide diluted aqueous solution hydrogen peroxide final oxidant. The scope proposed methodology was investigated aryl alkyl sulfides, vinyl dialkyl substrates, evidencing, general, good applicability. scaled-up synthesis (methylsulfonyl)benzene also demonstrated, leading to its...
The first in-flow selenium-mediated catalysis has been realized under eco-friendly conditions to convert alkenoic acids into hydroxy lactones with a high regio- and diastereo-selectivity ratio.
A simple and efficient method to convert elemental selenium into alkali metal diselenide was developed.The use of borohydride in a molar ratio 1 0.125 the presence base, under "on water" conditions ultrasound activation permitted reduction Se Se2 2-to be completed within minutes.Thus obtained aqueous solution then used multigram scale synthesis 2,2'-diselenobis(benzoic acid) (DSBA) valuable building block for development diverse pivotal selenorganic compounds.
Since ancient times, Cannabis and its preparations have found various applications such as for medical, recreational industrial purposes. Subsequently the 1930s, legislation in many countries has restricted use due to psychotropic properties. More recently, discovery of endocannabinoid system, including new receptors, ligands, mediators, role maintaining homeostasis human body possible implication physiological pathophysiological processes also been understood. Based on this evidence,...
Although global vaccination campaigns relieved the SARS-CoV-2 pandemic in terms of morbidity and mortality, capability virus to originate mutants may reduce vaccines efficiency, posing a serious risk fall into again. As result, there is need develop small molecules able tackle conserved viral targets, such as main protease (Mpro). Here series benzisoselenazolones diselenides were tested for their ability inhibit Mpro, then, most potent compounds, antiviral activity was measured vitro,...
Although global vaccination campaigns alleviated the SARS-CoV-2 pandemic in terms of morbidity and mortality, ability virus to originate mutants may reduce efficacy vaccines, posing a serious risk renewed pandemic. There is therefore need develop small molecules capable targeting conserved viral targets, such as main protease (Mpro). Here, series benzisoselenazolones diselenides were tested for their inhibit Mpro; then most potent compounds measured antiviral activity vitro, mechanism action...
Background: High-pressure chemistry offers the possibility to have faster and cleaner transformations thus addressing most of green principles. Among devices recently developed, Q-tube is worth mentioning since it cheap, easy handle, safe highly versatile. Methods: The recent interesting results obtained using such technique are reviewed in this study. Results: Examples assisted reactions organic synthesis presented a critical manner making where possible, comparison with conventional...
Divergent diastereoselectivities are observed under quite different reaction conditions. An in-depth investigation of the chiroptical properties products has been carried out.
1,4-Anhydro-4-seleno-D-talitol (SeTal) is a highly water-soluble selenosugar with interesting antioxidant and skin-tissue-repair properties; it stable in simulated gastric gastrointestinal fluids potential pharmaceutical ingredient that may be administered orally. Hepatic toxicity often major problem novel drugs can result drug withdrawal from the market. Predicting hepatotoxicity therefore essential to minimize late failure drug-discovery process. Herein, we report vitro studies evaluate...
New Ebselen-like derivatives resulted to be very strong in vitro inhibitors of SARS-CoV-2 main protease. We demonstrated that this activity mainly depends on the electrophilicity selenium atom is considerably higher N-substituted 1,2- benzoselenazol-3(2H)-ones respect corresponding diselenides allowing it rapidly attached by free thiols affording sulfur-selenium intermediates are further subjected thiol exchange processes. This data paints a complex scenario requires us consider Ebselen and...
Abstract Although global vaccination campaigns relieved the SARS-CoV-2 pandemic in terms of morbidity and mortality, capability virus to originate mutants may reduce vaccines efficiency, posing a serious risk fall into again. As result, there is need develop small molecules able tackle conserved viral targets, such as main protease (M pro ). Here series benzisoselenazolones diselenides were tested for their ability inhibit M , then, most potent compounds, antiviral activity was measured...
A convenient and cost-effective method for selective deuteration of rutin using biologically compatible bases D2O both as a deuterium source solvent is herein reported. The protocol benign inexpensive affording good results in very mild conditions allowing to reduce the required amount oxide. position C-H/C-D exchange level can be conveniently followed by 1H-NMR.
In the last decades, synthetic methods for construction of carbon-nitrogen bonds rapidly grew, due to important applications amino compounds in fine chemicals, biological and pharmaceutical sciences.The aminoselenylations alkenes alkynes are versatile reactions that usually occur with high regio-and stereo-control under mild reaction conditions.Linear cyclic can be prepared wide functional structural diversity using stoichiometric or catalytic amounts electrophilic selenium reagents.This...
Abstract Base induced activation of β‐naphthol toward the electrophilic aromatic substitution has been used for synthesis unprecedented 1,1’‐diselanediylbis(naphthalen‐2‐ol) fully characterized by means NMR and X‐Ray analysis. Its reactivity was studied novel chiral selenium containing heterocycles discovered. Chiroptical methods (VCD ECD) were successfully to define their absolute configuration these results represent first example reported organoselenium derivatives.
For a long time, the main biological activity of selenium derivatives was supposed to be connected their toxicity and some exotic theories correlated historical events poisoning. In 1285, Marco Polo, crossing Shanxi Province Western China, observed an unknown intoxication animals on his ships (loss hair) that later due selenosis in 1860, US Army surgeon documented first poisoning livestock, suggesting fascinating theory horse illness slowed General Custer's Cavalry relief may have been...
Ebselent has been recently reported as the most efficient hinibitors of Sars-Cov-2 main protease (Mpro) thought electrophilic covalent pro-oxidation reactive Cysteine 145. According to similar evidences in literature we can propose a general mechanism explore novel and promising application mild organoselenium centered electrophiles medicinal chemistry. New insights field non-covalent inhibition Mpro well antiviral SARS-Cov2 activity compounds will be here discussed
Two selanyl compounds, 5-(phenylselanyl)pentanoic acid ( 1 ) and 5-(benzylselanyl)pentanoic 2 ), were investigated for their reactivity towards one-electron oxidants. Compound was found to possess better antioxidant properties than compound .