A5050276174- Organoselenium and organotellurium chemistry
- Sulfur-Based Synthesis Techniques
- Organic Chemistry Cycloaddition Reactions
- X-ray Diffraction in Crystallography
- Free Radicals and Antioxidants
- Crystallization and Solubility Studies
- Organometallic Compounds Synthesis and Characterization
- Asymmetric Synthesis and Catalysis
- Synthesis and biological activity
- Chemical Synthesis and Reactions
- Chemical Reaction Mechanisms
- Crystallography and molecular interactions
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Chemical Reactions and Mechanisms
- Selenium in Biological Systems
- Synthesis and Catalytic Reactions
- Synthesis and Reactions of Organic Compounds
- Sulfur Compounds in Biology
- Molecular Spectroscopy and Structure
- Metal complexes synthesis and properties
- Advanced Chemical Physics Studies
- Inorganic and Organometallic Chemistry
- Coordination Chemistry and Organometallics
- Radical Photochemical Reactions
- Chemical Thermodynamics and Molecular Structure
Nicolaus Copernicus University
2015-2024
WSB Merito University in Torun
2024
Faculty (United Kingdom)
2016
University of Łódź
1992
Institute of Organic Chemistry
1992
Wojskowy Instytut Medyczny
1987
A new, general one step synthesis of N-substituted benzisoselenazol-3(2H)-ones based on the reaction o-iodobenzamides with lithium diselenide, is described. series alkyl and aryl derivatives was obtained in high yields (up to 98%). Their GPx-like antioxidant activity, tested by NMR, showed a significantly higher activity than ebselen.
New chiral camphane-derived benzisoselenazol-3(2H)-ones and corresponding diselenides have been synthetized using a convenient one-pot procedure. Se-N bond was efficiently converted to an Se-Se bond, which could also be easily re-oxidized the initial benzisoselenazolone moiety. The antioxidant activity of camphor derivatives evaluated compared reactivity series N-amino acid obtained by modified procedure involving improved synthesis isolation diseleno bis(dibenzoic) acid. most efficient...
Abstract A general and efficient method for the selenium‐catalyzed cyclofunctionalization reaction of alkenoic acids alkenols is presented. Hydrogen peroxide was used as green oxidant all products were obtained in very good yields.
Abstract The reaction of sodium diselenide with optically active alkyl tosylates or chlorides is found to be a useful method for the synthesis dialkyl diselenides. Optically monoterpene diselenides derived from menthane, carane, pinane, and bornane systems have been obtained. influence terpene fragment obtained on diastereomeric excess methoxyselenylation products has investigated. best result was observed (–)‐diisopinocamphyl diselenide. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451...
The evaluation of antioxidant and anticancer properties newly synthesized chiral phenylselenides revealed promising N -indanyl derivatives.
A series of new chiral benzisoselenazol-3(2H)-ones substituted on the nitrogen atom with three monoterpene moieties-p-menthane, pinane and carane-was synthesized. The compounds were obtained by reaction 2-(chloroseleno)benzoyl chloride an appropriate terpene amine, first synthesized a multistep methodology starting from corresponding alcohol (p-menthane system) or alkene (pinene carene systems). Compounds tested as antioxidants anticancer agents....
Reactive oxygen species (ROS) are responsible for many of civilization's diseases, including cancer, diabetes, and Alzheimer's disease, decomposition products in the food industry, deterioration physicochemical properties polymers nanomaterials.In recent years, several organoselenium compounds have been synthesized used as peroxide scavengers, which source antioxidant substances.This review aims to collect divide obtained last twelve years with activity, can prove helpful a) medicine...
Although global vaccination campaigns alleviated the SARS-CoV-2 pandemic in terms of morbidity and mortality, ability virus to originate mutants may reduce efficacy vaccines, posing a serious risk renewed pandemic. There is therefore need develop small molecules capable targeting conserved viral targets, such as main protease (Mpro). Here, series benzisoselenazolones diselenides were tested for their inhibit Mpro; then most potent compounds measured antiviral activity vitro, mechanism action...
A series of new chiral benzisoselenazol-3(2H)-ones and their corresponding diselenides bearing an o-amido function substituted on the nitrogen atom with various aliphatic aromatic moieties were synthesized. All derivatives representing pairs enantiomers or diastereoisomers obtained to thoroughly evaluate three-dimensional structure-activity correlation. First, bensisoselenazol-3(2H)-ones synthesized by reacting 2-(chloroseleno)benzoyl chloride appropriate enantiomerically pure amine. Then,...
Abstract Convenient routes for the synthesis of optically active methyl, phenyl, and dimonoterpenyl sulfides derived from carane, p-menthane, pinane, bornane were developed. Methyl have been obtained by reaction corresponding monoterpene thiolates with methyl iodide or tosylates. The reactions tosylates sodium benzenethiolate gave phenyl monoterpenyl sulfides. These used sulfur ylide-mediated to yield epoxides. Good diastereoselectivities up 99:1 low moderate enantioselectivities observed...
The ability of organoselenium molecules to mimic the activity antioxidant selenoenzyme glutathione peroxidase (GPx) allows for their use as or prooxidant modulators in several diseases associated with disruption cell redox homeostasis. Current drug design field is partially based on specific modifications known Se-therapeutics aimed at achieving more selective bioactivity towards particular targets, accompanied by low toxicity therapeutic window compounds tends be very narrow. Herein, we...
A convenient method of synthesis the optically active dialkyl diselenides from pinane group is described. The 3-hydroxy and 3-alkoxy derivatives bis(cis-myrtanyl) diselenide have been obtained. influence a structure resulting on diastereomeric excess methoxyselenenylation reaction selenocyclization investigated. Keywords: Asymmetric synthesis, Diselenides, Selenium, Terpenoids
Steric and electronic effects to the structure of a trityl moiety due chirality transfer by ECD method DFT calculation.
Abstract Synthesis of terpenyl selenides derived from limonene, menthol, caranol, and myrtanol is described. Three methodologies for the synthesis selenonium salts are compared. The results selenium‐mediated epoxidation through use isoselenocineole limonene methyl terpenyl, phenyl diterpenyl selenides, presented. influence solvent, counteranion, diastereomeric purity salt on enantioselectivity reaction discussed.
Scientific research has been underway for decades in order to develop an effective anticancer drug, and it become crucial find a novel chemotherapeutics the case of prostate cancer treatment. Ebselen derivatives have shown possess variety biological activities, including cytostatic cytotoxic action against tumor cells. In this study, effect mechanism two organoselenium compounds— (N-allyl-1,2-benzisoselenazol-3(2H)-one (N-allyl-BS) N-(3-methylbutyl)-1,2-benzisoselenazol-3(2H)-one)...