A5088828543- Coenzyme Q10 studies and effects
- Antioxidant Activity and Oxidative Stress
- Vitamin C and Antioxidants Research
- Advanced battery technologies research
- Vitamin K Research Studies
- Mitochondrial Function and Pathology
- Biochemical Acid Research Studies
- Adipose Tissue and Metabolism
- Calcium signaling and nucleotide metabolism
- Genomics, phytochemicals, and oxidative stress
- Advanced Battery Technologies Research
- Peroxisome Proliferator-Activated Receptors
- Metabolism, Diabetes, and Cancer
- Tea Polyphenols and Effects
- Muscle metabolism and nutrition
- Insect Utilization and Effects
- Exercise and Physiological Responses
- Metal complexes synthesis and properties
- Autophagy in Disease and Therapy
- Free Radicals and Antioxidants
- Adenosine and Purinergic Signaling
- Sirtuins and Resveratrol in Medicine
- Adipokines, Inflammation, and Metabolic Diseases
- Ion Channels and Receptors
- Genetics, Aging, and Longevity in Model Organisms
Marche Polytechnic University
2017-2024
Università di Camerino
2020-2022
Stazione Zoologica Anton Dohrn
2020
Lipid overload or metabolic stress has gained popularity in research that explore pathological mechanisms may drive enhanced oxidative myocardial damage. Here, H9c2 cardiomyoblasts were exposed to various doses of palmitic acid (0.06 1 mM) for either 4 24 hours study its potential physiological response cardiac cells. Briefly, assays performed included activity, cholesterol content, mitochondrial respiration, and prominent markers stress, as well determining changes potential, production...
Objectives: Physical exercise significantly impacts the biochemistry of organism. Ubiquinone is a key component mitochondrial respiratory chain and ubiquinol, its reduced active form, an emerging molecule in sport nutrition. The aim this study was to evaluate effect ubiquinol supplementation on biochemical oxidative stress indexes after intense bout exercise.Methods: 21 male young athletes (26 + 5 years age) were randomized two groups according double blind cross-over study, either...
Coenzyme Q10 (CoQ10) is an endogenous lipophilic quinone, ubiquitous in biological membranes and endowed with antioxidant bioenergetic properties, both crucial to the aging process. In fact, coenzyme synthesis known decrease age different tissues including skin. Moreover, can be inhibited by 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase inhibitors such as statins, that are widely used hypocholesterolemic drugs. They target a key enzymatic step along mevalonate pathway, involved...
In this randomized, double-blind, single-center trial (ANZCTR number ACTRN12619000436178) we aimed to investigate changes in endothelium-dependent vasodilation induced by ubiquinol, the reduced form of coenzyme Q10 (CoQ10), healthy subjects with moderate dyslipidemia. Fifty-one low-density lipoprotein (LDL) cholesterol levels 130–200 mg/dL, not taking statins or other lipid lowering treatments, (2.5%–6.0%) endothelial dysfunction as measured flow-mediated dilation (FMD) brachial artery, and...
During senescence, cells undergo distinctive biochemical and morphological changes become dysfunctional.MiRNAs are involved in the senescence process specific miRNAs can localize to mitochondria (mitomiRs).We hypothesized that part of typical alterations may depends on mitomiRs deregulation.Therefore, we thoroughly explored phenotype human endothelial undergoing replicative (sHUVECs) observed elongated/branched mitochondria, accumulation autophagic vacuoles (AVs), increased ROS IL-1β...
The target of the reduced fecundity with aging is oocyte. follicular fluid and its components are strongly linked environment maturing aim present study was to evaluate CoQ10 bioavailability in fluids after oral supplementation possible implication oocyte maturation.Fifteen female partners infertile couples, aged 31⁻46, undergoing IVF-ET taking 200 mg/day were compared unsupplemented patients. content, oxidative status total antioxidant capacity evaluated also relation maturation...
The levels of bioactive compounds in broccoli and their bioavailability following intake can be affected by the cooking procedures used for vegetable preparation. In present pilot study, we compared human plasma antioxidant (β-carotene, lutein isothiocyanate) phylloquinone (vitamin K) on seven volunteers before after administration boiled steamed broccoli. Moreover, isothiocyanate (ITCs) were also evaluated a single dose BroccoMax®, dietary supplement containing GLSs with active myrosinase....
Abstract SARM1 is a key regulator of conserved program axon degeneration increasingly linked to human neurodegenerative diseases. Pathological activation causes rapid NAD consumption, disrupting cellular homeostasis and leading degeneration. In this study, we develop antisense oligonucleotides targeting SARM1, demonstrating robust neuroprotection against morphological, metabolic, mitochondrial impairment in iPSC-derived dopamine neurons induced by the lethal neurotoxin vacor, potent...
Type 2 diabetic patients possess a two to four-fold-increased risk for cardiovascular diseases (CVD). Hyperglycemia, oxidative stress associated with endothelial dysfunction and dyslipidemia are regarded as pro-atherogenic mechanisms of CVD. In this study, high-fat diet-induced non-diabetic vervet monkeys were treated 90 mg/kg aspalathin-rich green rooibos extract (Afriplex GRT) 28 days, followed by 1-month wash-out period. Supplementation showed improvements in both the intravenous glucose...
Aging is a multifactorial phenomenon characterized by degenerative processes closely connected to oxidative damage and chronic inflammation. Recently, many studies have shown that natural bioactive compounds are useful in delaying the aging process. In this work, we studied effects of an vivo supplementation stilbenoid pterostilbene on lifespan extension Drosophila melanogaster. We found average flies both sexes was increased with higher effect females. The expression longevity related genes...
Reactive oxygen species (ROS) production in the skin is among highest compared to other organs, and a clear correlation exists between ROS aging. Many attempts are underway reduce oxidative stress by topical treatment or supplementation with antioxidants/cosmeceuticals, cultures of human dermal fibroblasts (HDF) widely used for these studies. Here, we examined influence tension on cell aging HDF how this impacted production, enzymatic nonenzymatic antioxidant response system, efficacy...
The diabetic heart has been linked with reduced endogenous levels of coenzyme Q9/10 (CoQ), an important antioxidant and component the electron transport chain. Although CoQ displayed cardioprotective potential in experimental models diabetes, impact N-acetyl cysteine (NAC) on mitochondrial energetics remains to be clarified. To explore these effects, high glucose-exposed H9c2 cardiomyocytes were used as model hyperglycemia-induced cardiac injury. results showed that glucose exposure caused...
Recent evidence shows that rooibos compounds, aspalathin and phenylpyruvic acid-2-O-β-d-glucoside (PPAG), can independently protect cardiomyocytes from hyperglycemia-related reactive oxygen species (ROS). While more potency by enhancing intracellular antioxidant defenses, PPAG acts as an anti-apoptotic agent. Thus, to further understand the protective capabilities of these compounds against hyperglycemia-induced cardiac damage, their combinatory effect was investigated compared metformin. An...