William J. Hadden

ORCID: 0000-0001-8574-636X
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About
Contact & Profiles
Research Areas
  • Total Knee Arthroplasty Outcomes
  • Pancreatic and Hepatic Oncology Research
  • Hip and Femur Fractures
  • Metabolomics and Mass Spectrometry Studies
  • Orthopaedic implants and arthroplasty
  • Cellular Mechanics and Interactions
  • Pelvic and Acetabular Injuries
  • Patient Satisfaction in Healthcare
  • Healthcare Systems and Technology
  • Knee injuries and reconstruction techniques
  • Cancer Cells and Metastasis
  • Bone fractures and treatments
  • Cholangiocarcinoma and Gallbladder Cancer Studies
  • Acute Kidney Injury Research
  • Cancer, Hypoxia, and Metabolism
  • Tracheal and airway disorders
  • Bone Tissue Engineering Materials
  • Cardiac, Anesthesia and Surgical Outcomes
  • Cancer, Lipids, and Metabolism
  • 3D Printing in Biomedical Research
  • Cardiac Arrest and Resuscitation
  • Radiomics and Machine Learning in Medical Imaging
  • Tissue Engineering and Regenerative Medicine
  • Hip disorders and treatments
  • MRI in cancer diagnosis

Ottawa Hospital
2020-2022

Ottawa Hospital Research Institute
2022

University of Ottawa
2021-2022

Primary Health Care
2022

Northern Sydney Local Health District
2016-2021

The University of Sydney
2016-2021

Sydney Orthopaedic Research Institute
2016-2021

The spatial presentation of mechanical information is a key parameter for cell behavior. We have developed method polymerization control in which the differential diffusion distance unreacted cross-linker and monomer into prepolymerized hydrogel sink results tunable stiffness gradient at cell-matrix interface. This simple, low-cost, robust was used to produce polyacrylamide hydrogels with gradients 0.5, 1.7, 2.9, 4.5, 6.8, 8.2 kPa/mm, spanning vivo physiological pathological landscape....

10.1073/pnas.1618239114 article EN Proceedings of the National Academy of Sciences 2017-05-15

Abstract Our study aimed to identify a urinary metabolite panel for the detection/diagnosis of pancreatic ductal adenocarcinoma (PDAC). PDAC continues have poor survival outcomes. One major reasons prognosis is advanced stage disease at diagnosis. Hence, identification novel and cost‐effective biomarker signature early could lead better Untargeted metabolomics was employed metabolite‐based Urinary metabolites from 92 patients (56 discovery cohort 36 validation cohort) were compared with 56...

10.1002/ijc.33368 article EN International Journal of Cancer 2020-10-31

Aims The aims of this study were to develop an in vivo model periprosthetic joint infection (PJI) cemented hip hemiarthroplasty, and monitor biofilm formation real-time. Methods Sprague-Dawley rats underwent hemiarthroplasty via the posterior approach with pre- postoperative gait assessments. Infection Staphylococcus aureus Xen36 was monitored photoluminescent imaging Pre- analyses performed compared. Postmortem micro (m) CT used assess implant integration; field emission scanning electron...

10.1302/0301-620x.103b7.bjj-2020-2435.r1 article EN The Bone & Joint Journal 2021-07-01

Increasing strain on public health resources in Canada, particular with respect to accessing specialist care, necessitates the exploration of alternative models care. The aim this study was assess efficacy electronic consultation (eConsult) providing orthopedic surgery service patients Champlain Local Health Integration Network (LHIN) Ontario.This a cross-sectional review all 564 LHIN referral requests received via Building Access Specialist through eConsult (BASE) system 2017. Primary...

10.1503/cjs.005820 article EN Canadian Journal of Surgery 2022-09-28

To assess the effect of eConsultation in providing Orthopaedic Surgery specialist service to patients Nunavut. A cross-sectional study 161 consultations received from primary care providers (PCPs) Nunavut via Champlain Building Access Specialist through eConsult (BASETM) over 2-year period January 2017 December 2018. Data captured were: reason for consultation, impact advice on referral, perceived value PCPs and time spent. avoided unnecessary in-person consultation 62% while catching 5%...

10.1080/22423982.2022.2151551 article EN cc-by-nc International Journal of Circumpolar Health 2022-11-30

A 29-year-old motor vehicle collision passenger presented with fractures of the pelvic ring, bilateral femurs, and right tibia/fibula. All were stabilized external fixation fixed definitively 48 hours later. Postoperatively, patient suffered rapid clinical decline. Emergent head computed tomography (CT) demonstrated tonsillar herniation loss gray-white matter differentiation. Although respiratory status remained uncompromised throughout presentation, pathology revealed extensive cerebral fat...

10.2106/jbjs.cc.20.00127 article EN JBJS Case Connector 2020-01-01
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