A5024300448- Tuberculosis Research and Epidemiology
- Diagnosis and treatment of tuberculosis
- Mycobacterium research and diagnosis
- Hepatitis B Virus Studies
- Pleural and Pulmonary Diseases
- Amoebic Infections and Treatments
- T-cell and B-cell Immunology
- Liver Disease Diagnosis and Treatment
- Immune Cell Function and Interaction
- Hepatitis C virus research
Harbin Medical University
2024
Fujian Medical University
2024
Orchestration of an effective T lymphocyte response at infection sites is critical for protection against Mycobacterium tuberculosis (Mtb) infection. However, the local cell immunity landscape in human poorly defined. Tuberculous pleural effusion (TPE), caused by Mtb, characterized influx leukocytes to space, providing a platform suitable delineating complex tissue responses Mtb Using single-cell transcriptomics and receptor sequencing, we analyzed mononuclear populations paired fluid...
A genome-wide association study has indicated the of numerous genes in 6p21.3 region with chronic hepatitis B virus (HBV) infection. In this study, we screened 12 representative single-nucleotide polymorphisms (SNPs) from and investigated their risk (CHB) to better understand molecular etiology underlying CHB Han Chinese population. Between March 2021 November 2022, included 183 patients (case group) 196 natural HBV clearance (control group). Allele typing selected SNPs was performed using...
BACKGROUNDCurrent diagnostic tools for tuberculous pleural effusion (TPE) are often inadequate, making accurate diagnosis challenging. Effective identification of TPE is critical ensuring proper treatment and preventing tuberculosis relapse. This study explored the potential granzyme A (GZMA) as a biomarker TPE.METHODSPatients with TPE, malignant (MPE), parapneumonic (PPE) were recruited into discovery validation cohorts. The cohort consisted 200 patients 100 MPE, while included 167 84 69...