A5026305418- Blood Pressure and Hypertension Studies
- Cardiovascular Health and Disease Prevention
- Hormonal Regulation and Hypertension
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular Disease and Adiposity
- Sodium Intake and Health
- Antioxidant Activity and Oxidative Stress
- Healthcare Regulation
- Cardiovascular and exercise physiology
- Heart Rate Variability and Autonomic Control
- Regulation of Appetite and Obesity
- Protease and Inhibitor Mechanisms
- Medication Adherence and Compliance
- Nutritional Studies and Diet
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Venous Thromboembolism Diagnosis and Management
- Cardiovascular Function and Risk Factors
- Adipose Tissue and Metabolism
- Eicosanoids and Hypertension Pharmacology
- Nutrition, Genetics, and Disease
- Migraine and Headache Studies
- Acute Myocardial Infarction Research
- Birth, Development, and Health
- Geography and Environmental Studies
- Heart rate and cardiovascular health
Universidade Estadual de Campinas (UNICAMP)
2013-2022
National Institute of Health Dr. Ricardo Jorge
2015-2020
Hospital Dr. Nélio Mendonça
2017-2020
Brazilian Biosciences National Laboratory
2016
Pontifícia Universidade Católica de Campinas
2016
Hospital de Clínicas da Unicamp
2015
National Council for Scientific and Technological Development
2012
Fundação de Amparo à Pesquisa do Estado de São Paulo
2012
Instituto Nacional de Saúde
1995
Oxidative damage and inflammation are both implicated in the genesis of hypertension; however, mechanisms by which these stimuli promote hypertension not fully understood. Here, we have described a pathway hypertensive dendritic cell (DC) activation T cells, ultimately leading to hypertension. Using multiple murine models hypertension, determined that proteins oxidatively modified highly reactive γ-ketoaldehydes (isoketals) formed accumulate DCs. Isoketal accumulation was associated with DC...
Increased levels of inflammatory biomarkers such as interleukin-6 (IL-6), 10 (IL-10), 1β (IL-1β), tumor necrosis factor-α (TNF-α) high-sensitivity C-reactive protein (hs-CRP) are associated with arterial stiffness in hypertension. Indeed, resistant hypertension (RHTN) leads to unfavorable prognosis attributed poor blood pressure (BP) control and target organ damage. This study evaluated the potential impact on RHTN.In this cross-sectional study, 32 RHTN, 20 mild hypertensive (HTN)...
Resistant hypertensive (RHTN) patients have endothelial dysfunction and aldosterone excess, which contribute to the development of resistance antihypertensive treatment cardiovascular complications. Biophysical forces within arterial wall provide functional regulation stiffness. Carotid–femoral pulse wave velocity (PWV) flow-mediated brachial artery dilation (FMD) can be used evaluate vascular stiffness function. Although both techniques been in several studies patients, it is unknown...
Aim . The present study compared the acute effects of aerobic (AER), resistance (RES), and combined (COM) exercises on blood pressure (BP) levels in people with resistant hypertension (RH) nonresistant (NON-RH). Methods Twenty patients (10 RH 10 NON-RH) were recruited randomly performed three exercise sessions a control session. Ambulatory BP was monitored over 24 hours after each experimental Results Significant reductions ambulatory found AER, RES, COM sessions. Notably, reduced during...
This study aimed to evaluate the effects of glycated hemoglobin (HbA 1c ) on flow‐mediated dilation, intima‐media thickness, pulse wave velocity, and left ventricular mass index in patients with resistant hypertension (RHTN) comparing RHTN–controlled diabetes mellitus RHTN–uncontrolled type 2 mellitus. Two groups were formed: HbA <7.0% ( : n = 98) ≥7.0% RHTN –uncontrolled mellitus: 122). Intima‐media thickness dilation measured by high‐resolution ultrasound, echocardiography, arterial...
Activation of the renin-angiotensin-aldosterone system (RAAS) and abnormal adipokine levels are biological alterations that affect blood pressure regulation interact to link hypertension, obesity metabolic diseases. While imbalanced hormones produced by adipocytes including hypo-adiponectinaemia hyperleptinaemia were reported in little is known about how antihypertensive therapy affects these alterations. This study aimed evaluate effects enalapril on plasma adiponectin leptin hypertensive...
Resistant hypertension (RHTN) is a multifactorial and polygenic disease, frequently associated with obesity. Low plasma adiponectin levels, hormone produced by the adipose tissue, were RHTN. Single nucleotide polymorphisms (SNPs) -11377C/G (rs266729) +276G/T (rs1501299) in ADIPOQ (adiponectin gene) hypertension. This study evaluated association between two SNPs (-11377C/G +276G/T) levels comprised 109 patients RHTN genotyped for both polymorphisms. A cross-sectional was designed to compare...
There is evidence that subclinical systemic inflammation present in resistant hypertension (RHTN).The aim of the study was to develop an integrated measure circulating cytokines/adipokines involved pathophysiology RHTN.RHTN (n = 112) and mild moderate hypertensive (HTN) subjects (n=112) were studied a cross-sectional design. Plasma (TNF-alpha, interleukins [IL]-6, -8, -10, leptin adiponectin) values divided into tertiles, which score ranging from 1 (lowest tertile) 3 (highest assigned. The...
Background: Metabolic syndrome (MetS) is widespread among hypertensive patients. Clinical features and potential biomarkers of MetS in the presence hypertension resistant (RHTN) represent a great area interest for investigation. Objective: The purpose this study was to evaluate prevalence clinical associated with it mild moderate hypertensives. Methods: This cross-sectional included 236 patients, (i) 129 patients (ii) 107 RHTN. We measured blood pressure (BP) adipokines levels, performed...
Resistant hypertension (RHTN) and target organ damage are linked to increased inflammatory biomarkers, which may regulate adhesion molecules, such as intracellular molecule-1 (ICAM-1); vascular cell (VCAM-1); the platelet (P-selectin) endothelial (E-selectin) selectins. We investigated a previously unknown relationship between soluble P-selectin (sP-selectin), E-selectin (sE-selectin), ICAM-1 (sICAM-1) VCAM-1 (sVCAM-1) with RHTN damage.We included 110 subjects diagnosed for true 112...
The balance between matrix metalloproteinases (MMP) and their tissue inhibitors (TIMP) plays a key role in the development of hypertension obesity. We aimed to evaluate levels MMP-2 9 TIMP-2 -1 obese non-obese apparent treatment-resistant hypertensive subjects (aTRH) its association with cardiac hypertrophy. This cross-sectional study enrolled 122 divided into aTRH (n = 67) 55) group. Clinical biochemical data were compared both groups, including office BP, ambulatory plasma 9, 1 left...
Background: Hypertension is a chronic, low-grade inflammation process associated with the release of cytokines and development target organ damage. Deregulated monocyte chemoattractant protein-1 (MCP-1) levels have been high blood pressure cardiovascular complications; however, mechanisms involved are complex not fully understood. Objective: This study aimed to compare MCP-1 in patients resistant (RH) versus mild-to-moderate (HTN) hypertension their association presence or absence left...