Alessandro Mazzucco

ORCID: 0000-0001-8593-4926
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About
Contact & Profiles
Research Areas
  • Cardiac Valve Diseases and Treatments
  • Cardiac Structural Anomalies and Repair
  • Congenital Heart Disease Studies
  • Aortic Disease and Treatment Approaches
  • Infective Endocarditis Diagnosis and Management
  • Mechanical Circulatory Support Devices
  • Cardiac and Coronary Surgery Techniques
  • Cardiac Ischemia and Reperfusion
  • Transplantation: Methods and Outcomes
  • Cardiac tumors and thrombi
  • Cardiac Arrest and Resuscitation
  • Cardiac, Anesthesia and Surgical Outcomes
  • Coronary Artery Anomalies
  • Pulmonary Hypertension Research and Treatments
  • Cardiovascular and Diving-Related Complications
  • Aortic aneurysm repair treatments
  • Tracheal and airway disorders
  • Cardiovascular Issues in Pregnancy
  • Cardiac pacing and defibrillation studies
  • Orthopaedic implants and arthroplasty
  • Cardiovascular Function and Risk Factors
  • Adipose Tissue and Metabolism
  • Cardiac Imaging and Diagnostics
  • Organ Transplantation Techniques and Outcomes
  • Cardiac Arrhythmias and Treatments

University of Verona
2008-2020

October 6 University
2014

Fundación Juan March
2014

Istituto Tecnico Industriale Alessandro Volta
2011-2013

Université de Lille
2013

Fistula Foundation
2012

University College London
2010

Ann Arbor Center for Independent Living
2010

Wilmington University
2010

Foundation of Cardiac Surgery Development
2009

High plasma levels of coagulation factor VII have been suggested to be predictors death due coronary artery disease. Since polymorphisms in the gene contribute variations levels, such may associated with risk myocardial infarction, which is precipitated by thrombosis.

10.1056/nejm200009143431104 article EN New England Journal of Medicine 2000-09-14

Background— The Ross operation is an alternative to mechanical aortic valve replacement in the young. Early dilatation of pulmonary autograft root exposed systemic circulation has been reported. To define prevalence of, risk factors for, and consequences late dilatation, outcome all consecutive patients operated since May 1994 was reviewed. Methods Results— Ninety one patients, 77 males 14 females, with at least 1 year follow-up underwent cross-sectional clinical echocardiographic...

10.1161/01.cir.0000089183.92233.75 article EN Circulation 2003-09-09

Abstract In bicuspid aortic valve (BAV) disease, the role of genetic and hemodynamic factors influencing ascending pathology is controversial. To test effect BAV geometry on flow, a finite element analysis was undertaken. A surface model root aorta obtained from magnetic resonance images patients with tricuspid using segmentation facilities image processing code Vascular Modeling Toolkit (developed at Mario Negri Institute). Analytical models (antero‐posterior [AP], type 1 latero‐lateral, 2...

10.1111/j.1525-1594.2009.00989.x article EN Artificial Organs 2010-07-06

<h3>Objective</h3> Children undergoing Ross operation were expected to have longer autograft, but shorter homograft durability compared with adults. In order define the outcome in second decade after children, a nationwide review of 23 years experience was undertaken. <h3>Methods</h3> 305 children underwent 11 paediatric units between 1990 and 2012. Age at surgery 9.4±5.7 years, indication aortic stenosis 103 patients, regurgitation 109 mixed lesion 93. 116 (38%) patients had prior...

10.1136/heartjnl-2014-305873 article EN Heart 2014-07-23

Extracorporeal circulation contributes to morbidity after open-heart surgery by causing a systemic inflammatory reaction. Modified ultrafiltration is technique able remove the fluid overload and mediators associated with use of cardiopulmonary bypass. It has been shown reduce cardiac operations in children, but impact on adult procedures unknown.Five hundred seventy-three consecutive patients were prospectively randomized either bypass (treatment) or no (control). Parsonnet score was used...

10.1161/hc37t1.094931 article EN Circulation 2001-09-18

BACKGROUND We performed a comparative study on Ca2+ release activity of the sarcoplasmic reticulum and calcium sensitivity contractile apparatus chemically skinned myocardial fibers obtained from four nonfailing human hearts 13 excised patients with idiopathic dilated cardiomyopathy. METHODS AND RESULTS was studied by following isometric tension developed challenged solutions decreasing pCa. monitored indirectly measurement caffeine. observed no significant difference cooperativity between...

10.1161/01.cir.85.2.518 article EN Circulation 1992-02-01

Clinical small-caliber vascular prostheses are unsatisfactory. Reasons for failure early thrombosis and late intimal hyperplasia. We thus prepared biodegradable using electrospun polycaprolactone (PCL) with slow-releasing paclitaxel (PTX), an antiproliferative drug.PCL solutions containing PTX were used to prepare nonwoven nanofibre-based 2-mm ID prostheses. Mechanical morphological properties drug loading, distribution, release studied in vitro. Infrarenal abdominal aortic replacement was...

10.1161/circulationaha.109.848242 article EN Circulation 2009-09-14

IL-17A and IL-17F are pro-inflammatory cytokines which induce the expression of several cytokines, chemokines matrix metalloproteinases (MMPs) in target cells. IL-17 have recently attracted huge interest due to their pathogenic role diseases such as arthritis inflammatory bowel disease although a for myocardial infarction (MI) has not previously been described.In vivo MI was performed by coronary artery occlusion absence or presence neutralizing antibody blocking actions vivo. signaling also...

10.1016/j.ijcard.2011.08.849 article EN cc-by-nc-nd International Journal of Cardiology 2011-11-14
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