A5035340228- Blood transfusion and management
- Aging, Elder Care, and Social Issues
- Viral Infections and Outbreaks Research
- Blood donation and transfusion practices
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Viral Infections and Vectors
- COVID-19 Clinical Research Studies
- Platelet Disorders and Treatments
- Disaster Response and Management
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Impact on Reproduction
- Enterobacteriaceae and Cronobacter Research
- Blood groups and transfusion
- Bacterial Infections and Vaccines
- Hepatitis B Virus Studies
- Global Health Care Issues
- Periodontal Regeneration and Treatments
- Myasthenia Gravis and Thymoma
- Intergenerational Family Dynamics and Caregiving
- Lymphatic Disorders and Treatments
- Mesenchymal stem cell research
- Substance Abuse Treatment and Outcomes
- Autoimmune Neurological Disorders and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Reconstructive Surgery and Microvascular Techniques
American Red Cross
2021-2024
Terumo (United States)
2020
Western Carolina University
2019
University of Colorado Denver
2018-2019
Corgenix (United States)
2014-2016
National Institute of Neurological Disorders and Stroke
1982
Limited clinical and laboratory data are available on patients with Ebola virus disease (EVD). The Kenema Government Hospital in Sierra Leone, which had an existing infrastructure for research regarding viral hemorrhagic fever, has received cared EVD since the beginning of outbreak Leone May 2014.
Background Lassa fever (LF), an often-fatal hemorrhagic disease caused by virus (LASV), is a major public health threat in West Africa. When the violent civil conflict Sierra Leone (1991 to 2002) ended, international consortium assisted restoration of LF program at Kenema Government Hospital (KGH) area with world's highest incidence disease. Methodology/Principal Findings Clinical and laboratory records patients presenting KGH Ward post-conflict period were organized electronically....
Ebola virus disease (EVD) is a severe viral illness caused by (EBOV). The 2013-2016 EVD outbreak in West Africa the largest recorded, with >11 000 deaths. Development of ReEBOV Antigen Rapid Test (ReEBOV RDT) was expedited to provide point-of-care test for suspected cases.Recombinant EBOV protein 40 antigen used derive polyclonal antibodies RDT and enzyme-linked immunosorbent assay development. limits detection (LOD), specificity, interference were analytically validated on basis Food Drug...
Steroid hormones regulate cell physiology and immune function, with dysregulated steroidogenesis promoting cancer progression by supporting tumour growth suppressing anti-tumour immunity. Targeting CYP11A1, the first rate-limiting enzyme in steroid biosynthesis, has shown promise therapy, but safe effective inhibitors remain an unmet need. Undertaking silico structure-based drug repurposing approach, we found Posaconazole as inhibitor of CYP11A1. The docking pose analysis showed that can...
Background. The 2013–2016 West African Ebola virus disease (EVD) epidemic is the largest recorded. Triage on basis of clinical signs had limited success, and time to diagnosis by quantitative reverse transcription–polymerase chain reaction (qRT-PCR) could exceed 5 days. Here we describe development field validation ReEBOV Antigen Rapid Test (ReEBOV RDT) aid triage individuals with suspected EVD. Methods. Samples from patients EVD were submitted Kenema Government Hospital, Sierra Leone, for...
Abstract Background Cold storage reduces posttransfusion survival of platelets; however, it can improve platelet activation, lower risk bacterial contamination, and extend shelf‐life compared to room temperature (RT) storage. To facilitate large‐scale availability, manufacturing process optimization is needed, including understanding the impact variables on potency safety. Short time requirements from collection challenging for large blood centers complete resuspension qualify platelets...
Abstract Background Severe T‐cell lymphopenia of uncertain clinical significance has been observed in frequent apheresis platelet donors. Two commonly used plateletpheresis instruments are the Trima Accel, which uses a leukoreduction system (LRS) chamber to trap leukocytes and Fenwal Amicus, does not use an LRS chamber. Study Design Methods We performed international, multicenter, observational study comparing populations donors collected exclusively using instrument ( n = 131) or Amicus...
Abstract Background and Objectives Platelets for transfusion are evaluated in vivo quality using recovery survival measurements healthy human subjects. Radiolabelling is the standard tracing platelets post‐transfusion but imposes logistical technical limitations. This study investigates vitro feasibility of labelling with calcein family fluorescent dyes as an alternative to radioisotopes or biotin. Materials Methods Protocols radiolabelling were adapted use acetoxymethyl ester (CAM) Labelled...
During 2018-2021, eight septic transfusion reactions occurred from of platelet units contaminated with Acinetobacter spp., Staphylococcus saprophyticus, Leclercia adecarboxylata, or a combination those environmental organisms. Whether biofilm formation contributed to evasion bacterial risk mitigations, including culture, point-of-care testing, pathogen-reduction technology, is unclear. We designed 12-well plate-based method evaluate determinants single-species and multispecies in platelets....
<title>Abstract</title> As faculty and students continue to acclimate learning in a post-COVID world, better understanding of student experiences during COVID can help inform successful online pedagogies for the future. One emergent debate is whether should require turn on their video cameras synchronous class as way taking attendance measuring engagement. Some say requiring contrary trauma-informed teaching practices. Others argue that asking reasonable request. Through an survey, this...
Demand for low-titer Group O whole blood (LTOWB) is increasing trauma. The (WB) platelet-sparing (WB-SP) filter enables leukoreduction (LR) while retaining platelet quantity and function; however, in the United States WB must be filtered placed cold within 8 h of collection. A longer processing window would facilitate improved logistics supply LR-WB to meet growing medical need. This study evaluated impact filtration timing from <8 <12 on quality LR-WB.Thirty units were collected healthy...
Oligoclonal IgG bands were demonstrated in the cerebrospinal fluid of guinea pigs with experimental allergic encephalitis before clinical signs developed. No found serum these animals nor CSF or control animals. Immunofixation techniques that immunoglobulins γ G class.