A5020340962- Cardiomyopathy and Myosin Studies
- Muscle Physiology and Disorders
- Cardiovascular Effects of Exercise
- Genetic Neurodegenerative Diseases
- Viral Infections and Immunology Research
Bristol-Myers Squibb (United States)
2020-2024
In addition to a conventional relaxed state, fraction of myosins in the cardiac muscle exists low-energy consuming super-relaxed (SRX) which is kept as reserve pool that may be engaged under sustained increased demand. The and states are widely assumed correspond structure where myosin heads an open configuration, free interact with actin, closed inhibiting binding respectively. Disruption SRX population emerging model different heart diseases, such hypertrophic cardiomyopathy, results...
Hypertrophic cardiomyopathy (HCM) is a genetic disease of the heart characterized by thickening left ventricle (LV), hypercontractility, and impaired relaxation. HCM caused primarily heritable mutations in sarcomeric proteins, such as β myosin heavy chain. Until recently, medications clinical use for did not directly target underlying contractile changes sarcomere. Here, we investigate novel small molecule, RLC-1, identified bovine cardiac myofibril high-throughput screen. RLC-1 highly...
Myosin regulatory light chain (RLC) is a subunit of the myosin molecule, which plays major role in stabilizing Interacting Head Motif (IHM) non-striated muscle. However, striated muscle, its purpose less well defined, and it only past decade that researchers have started unraveling function RLC phosphorylation muscle contraction. In this study, we report human cardiac forming Super-Relaxed State (SRX) reconstituted full-length thick filaments show removal destabilizes ability to form SRX...
ABSTRACT In addition to a conventional relaxed state, fraction of myosins in the cardiac muscle exists newly-discovered low-energy consuming super-relaxed (SRX) which is kept as reserve pool that may be engaged under sustained increased demand. The and states are widely assumed correspond respectively structure where myosin heads an open configuration, free interact with actin, closed inhibiting binding actin. Disruption SRX population different heart diseases, such hypertrophic...
Myosin regulatory light chain (RLC) is a major subunit of the myosin molecule, role which has been well-characterized in non-striated muscle. However, striated muscle, its purpose less well defined, and it only past decade that researchers have started unraveling function RLC phosphorylation muscle contraction. Mutations this protein result ~ 2% total familial cardiomyopathy, an autosomal dominant disorder, manifested by ventricular septal hypertrophy myofibrillar disarray can lead to sudden...