A5041153130- Cardiomyopathy and Myosin Studies
- Electrochemical sensors and biosensors
- Cardiac electrophysiology and arrhythmias
- Force Microscopy Techniques and Applications
- Advanced Chemical Sensor Technologies
- Cardiovascular Effects of Exercise
- Muscle Physiology and Disorders
- Muscle activation and electromyography studies
- Analytical Chemistry and Sensors
- Viral Infectious Diseases and Gene Expression in Insects
- CRISPR and Genetic Engineering
- Traumatic Brain Injury Research
- Neuroscience and Neural Engineering
- Family Caregiving in Mental Illness
- Ion channel regulation and function
- Congenital heart defects research
- Mental Health Treatment and Access
- Schizophrenia research and treatment
- Cardiac Arrest and Resuscitation
- Cardiovascular Function and Risk Factors
- Advanced Sensor and Energy Harvesting Materials
- Advanced Fluorescence Microscopy Techniques
- Phagocytosis and Immune Regulation
- Receptor Mechanisms and Signaling
- Cellular Mechanics and Interactions
University of Washington
2020-2024
Stony Brook School
2023
Stony Brook University
2023
SUNY Plattsburgh
2017
Universitat de València
2001
INTRODUCTION: Stress-induced hyperglycemia (SIH) independently predicts poor outcomes in patients with primary intracerebral hemorrhage (ICH). However, no studies have directly compared between ICH SIH to those pre-existing diabetes mellitus (DM). This makes it difficult discern whether adverse are related sympathetic dysregulation that occurs as a sequela of or secondary chronic endothelial dysfunction DM. METHODS: We collected data for 814 diagnosis who presented Stony Brook Hospital from...
Controlled intervention studies carried out in families of schizophrenia patients have been shown to a positive impact relapse prevention, but it remains be seen whether different forms family affect outcomes other than and hospital readmission ways. This study compared the outcome profile relevant clinical variables after two strategies for public health care Spanish sample. We conducted randomized controlled comparing (1) relatives group (RG) (2) single-family behavioral therapy (BFT),...
Abstract H 2 O is a key oxidant in mammalian biology and pleiotropic signaling molecule at the physiological level, its excessive accumulation conjunction with decreased cellular reduction capacity often found to be common pathological marker. Here, we present red fluorescent Genetically Encoded Indicator (GEHI) allowing versatile optogenetic dissection of redox biology. Our new GEHI, oROS-HT, chemigenetic sensor utilizing HaloTag Janelia Fluor (JF) rhodamine dye as reporters. We developed...
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Hypertrophic cardiomyopathy (HCM) is a genetic disease of the heart characterized by thickening left ventricle (LV), hypercontractility, and impaired relaxation. HCM caused primarily heritable mutations in sarcomeric proteins, such as β myosin heavy chain. Until recently, medications clinical use for did not directly target underlying contractile changes sarcomere. Here, we investigate novel small molecule, RLC-1, identified bovine cardiac myofibril high-throughput screen. RLC-1 highly...
Muscle function within an organism depends on the feedback between molecular and meter-scale processes. Although motions of muscle's contractile machinery are well described in isolated preparations, only a handful experiments have documented kinematics lattice occurring when multi-scale interactions fully intact. We used time-resolved X-ray diffraction to record myofilament normal operating context: tethered flight Manduca sexta As primary muscles M.sexta synchronous, we these results...
The timing and magnitude of force generation by a muscle depend on complex interactions in compliant, contractile filament lattice. Perturbations these can result cardiac diseases. In this study, we address the fundamental challenge connecting temporal features twitches to underlying rate constants their perturbations associated with genetic cardiomyopathies. Current state-of-the-art metrics for characterizing mechanical consequence disease do not utilize information embedded complete time...
ABSTRACT Muscle’s function within an organism depends on the feedback between molecular to meter-scale processes. While motions of muscle’s contractile machinery are well described in isolated preparations, only a handful experiments have documented kinematics lattice occurring when multi-scale interactions fully intact. We used time-resolved x-ray diffraction record myofilament normal operating context: tethered flight Manduca sexta . Since primary muscles synchronous, we these results...