With a sudden move to remote and online teaching due COVID-19 pandemic, Organic Chemistry became more challenging for both students educators with the emergence of new technological challenges instructional strategies. The I class at SUNY Plattsburgh was shifted an learning model in attempt mimic face-to-face as well maintaining active learning. This communication highlights instructor's perspectives on insights gained (lecture component) Spring 2020 semester time COVID-19. A combination...

Reversible addition-fragmentation chain transfer (RAFT) polymerization technique was used for the fabrication of stable core cross-linked micelles (CCL) with thermoresponsive and degradable cores. Well-defined poly(2-methacryloyloxyethyl phosphorylcholine), poly(MPC) macroRAFT agent, first synthesized narrow molecular weight distribution via RAFT process. These CCL (termed as nanogels) hydrophilic shell consisting poly(methoxydiethylene glycol methacrylate) (poly(MeODEGM) poly(2-aminoethyl...

Cellulose nanocrystals (CNCs) continue to gain increasing attention in the materials community as sustainable nanoparticles with unique chemical and mechanical properties. Their nanoscale dimensions, biocompatibility, biodegradability, large surface area, low toxicity make them promising for biomedical applications. Here, we disclose a facile synthesis of poly(2-aminoethylmethacrylate) (poly(AEM)) poly(N-(2-aminoethylmethacrylamide) (poly(AEMA)) CNC brushes via surface-initiated...

The development of polymeric systems with tailored properties as nonviral gene carriers continues to be a challenging and exciting field research. We report here the synthesis characterization biodegradable, temperature- pH-sensitive carbohydrate-based cationic nanogels effective delivery Hep G2 cells. temperature-sensitive property allows their facile complexation DNA, while degradation followed by release plasmid in endosome. are synthesized via reversible addition-fragmentation chain...

In this present work, terminal amino-functionalized nanocrystalline cellulose derivatives were prepared using a simple two-step protecting group-free protocol under aqueous reaction conditions at room temperature. Carboxylate groups first introduced onto the surface of (NCC) via TEMPO-mediated oxidation. Then, surface-carboxylated NCC with bifunctional amines small alkyl chain length by EDC/NHS-mediated coupling furnished desired aminated an amide linkage. Surface covalent functionalization...

Cellulose nanocrystals (CNCs) are renewable nanosized materials with exceptional physicochemical properties that continue to garner a high level of attention in both industry and academia for their potential high-end material applications. These rod-shaped CNCs appealing due non-toxic, carbohydrate-based chemical structure, large surface area, the presence ample hydroxyl groups modifications. CNCs, generally prepared from sulfuric acid-mediated hydrolysis native cellulose, display an anionic...

Crystalline cellulose nanocrystals (CNCs) have emerged as novel materials for a wide variety of important applications such nanofillers, nanocomposites, surface coatings, regenerative medicine and potential drug delivery. CNCs needle-like structure with sizes in the range 100-200 nm long 5-20 mean aspect ratio 10-100. Despite great applicability CNCs, very little is known about their immunogenicity. Needle-like been to evoke an immune response particular activate (NOD-like receptor, pyrin...

An indirect method for effecting radical carbocyclization onto aromatic rings is described. Cross-conjugated dienones such as 13, readily prepared by Birch reduction of tert-butyl esters, in situ alkylation, and oxidation (10 --> 11 12 13), undergo cyclization; the products (14) are aromatized silylation, Saegusa oxidation, treatment with BiCl3.H2O. A noteworthy feature this route that it provides opportunities to attach an additional substituent original ring.

Polysaccharides have been shown to immunomodulatory properties. Modulation of the immune system plays a crucial role in physiological processes as well treatment and/or prevention autoimmune and infectious diseases. Cellulose nanocrystals (CNCs) are derived from cellulose, most abundant polysaccharide on earth. CNCs an emerging class crystalline nanomaterials with exceptional physico-chemical properties for high-end applications commercialization prospects. The aim this study was design,...

Abstract: Cellulose nanocrystals (CNCs) have emerged as promising candidates for a number of bio-applications. Surface modification CNCs continues to gain significant research interest it imparts new properties the surface design multifunctional CNCs-based materials. A small chemical can potentially lead drastic behavioral changes cell-material interactions thereby affecting intended bio-application. In this work, unmodified were covalently decorated with four different organic moieties such...

Cationic nanomaterials are promising candidates for the development of effective antibacterial agents by taking advantage nanoscale effects as well other exceptional physicochemical properties nanomaterials. In this study, carboxylated cellulose nanocrystals (cCNCs) derived from softwood pulp were coated with cationic poly(diallyldimethylammonium chloride) varying molecular weights. The resulting (cCNCs–PDDA) characterized their structural and morphological using Fourier transform infrared...

To maintain a safe laboratory working environment, academic institutions are highly committed to providing safety training all employees, and engaging educators students in the process must be an integral component of overall program. At SUNY Plattsburgh, annual mandatory is required for employees. One main challenges trying high level engagement during session. This recently led designing simple hands-on breakout activity teach about practices. The mimics fun typical "escape room" game....

Cellulose nanocrystals (CNCs) have great potential in many areas of research, applications, and future commercialization prospects. Recently, CNCs emerged as attractive candidates for biomedical applications such drug gene delivery systems. As such, cytotoxicity studies been the major focus past decade. However, despite rod-like nature CNCs, immune response surface-modified is not well investigated. The current study examined antioxidant induced by grafted with β -cyclodextrin (CNCs- -CD) a...

Embracing diversity, equity and inclusion (DEI) in the chemistry classroom is crucial for creating an inclusive learning environment that will have a positive effect on student's learning, success, hence, retention science, technology, engineering mathematics (STEM). As such, number of DEI approaches recently been identified to foster awareness appreciation into undergraduate education. However, addition awareness, studies or educational whereby students are being exposed some basic...