A5064275125- Nerve injury and regeneration
- Phytochemistry and biological activity of medicinal plants
- Bioactive Compounds and Antitumor Agents
- Pain Mechanisms and Treatments
- Metabolism and Genetic Disorders
- Mitochondrial Function and Pathology
- DNA Repair Mechanisms
- Biochemical effects in animals
- Botulinum Toxin and Related Neurological Disorders
- Biological and pharmacological studies of plants
- Toxin Mechanisms and Immunotoxins
Universiti Sains Malaysia
2013-2025
Hospital Universiti Sains Malaysia
2018
Aloe emodin, one of the active compounds found in vera leaves, plays an important role regulation cell growth and death. It has been reported to promote anti-cancer effects various cancer cells by inducing apoptosis. However, mechanism apoptosis this agent is poorly understood glioma cells. This research investigate cycle arrest aloe emodin on U87 human malignant showed a time- dose-dependent inhibition proliferation decreased percentage viable via induction Characteristic morphological...
This study investigated the role of NR2B in a modulated pain process painful diabetic neuropathy (PDN) rat using various stimuli.Thirty-two Sprague-Dawley male rats were randomly allocated into four groups (n=8): control, diabetes mellitus (DM) and treated with ifenprodil at lower dose (0.5 μg/day) (I 0.5) or higher (1.0 1.0). DM was induced by single injection streptozotocin 60 mg/kg on day 0 experimentation. Diabetic status assessed 3 The responses both tactile thermal stimuli (baseline),...
Although the role of nuclear-encoded gene alterations has been well documented in brain tumor development, involvement mitochondrial genome tumorigenesis not yet fully elucidated and remains controversial. The present study aimed to identify mutations DNA (mtDNA) control region D-loop patients with tumors Malaysia. A mutation analysis was performed which extracted from paired tissue blood samples obtained 49 tumors. amplified using PCR technique, genetic data sequencing analyses were...
Glioblastoma, the most aggressive and malignant form of glioma, appears to be resistant various chemotherapeutic agents. Hence, approaches have been intensively investigated targeti specific molecular pathways involved in glioblastoma development progression. Aloe emodin is believed modulate expression several genes cancer cells. We aimed understand mechanisms underlying therapeutic effect on gene profiles human U87 cell line utilizing microarray technology. The analysis revealed that a...