A5041272084- Respiratory Support and Mechanisms
- Neonatal Respiratory Health Research
- Cancer survivorship and care
- Atomic and Subatomic Physics Research
- Nausea and vomiting management
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Thermal Regulation in Medicine
- Cardiac Arrest and Resuscitation
- Cardiac, Anesthesia and Surgical Outcomes
- Neuroscience of respiration and sleep
- Anesthesia and Pain Management
- Airway Management and Intubation Techniques
- Enhanced Recovery After Surgery
- Inhalation and Respiratory Drug Delivery
- Pain Management and Opioid Use
- Palliative Care and End-of-Life Issues
- Music Therapy and Health
- Ultrasound in Clinical Applications
- Economic and Financial Impacts of Cancer
- Opioid Use Disorder Treatment
- Advanced MRI Techniques and Applications
- Pulmonary Hypertension Research and Treatments
- Breast Implant and Reconstruction
- Lung Cancer Diagnosis and Treatment
- Neutropenia and Cancer Infections
Memorial Sloan Kettering Cancer Center
2014-2024
Cornell University
2018-2023
Weill Cornell Medicine
2021-2022
Botswana Harvard AIDS Institute Partnership
2021
Pfizer (United Kingdom)
2018
Novartis (Ireland)
2018
Walgreens Boots Alliance (United Kingdom)
2018
Digital Research Alliance of Canada
2018
Ipsen (France)
2018
Harvard University
1995-2015
Venegas, José G., R. Scott Harris, and Brett A. Simon.A comprehensive equation for the pulmonary pressure-volume curve. J. Appl. Physiol. 84(1): 389–395, 1998.—Quantification of (P-V) curves is often limited to calculation specific compliance at a given pressure or recoil (P) volume (V). These parameters can be substantially different depending on arbitrary used in comparison may lead erroneous conclusions. We evaluated sigmoidal form, V = + b[1 +[Formula: see text]] −1 , its ability...
Although the pathogenic and genetic basis of acute lung injury (ALI) remains incompletely understood, identification novel ALI biomarkers holds promise for unique insights. Expression profiling in animal models (canine murine) human detected significant expression pre-B-cell colony-enhancing factor (PBEF), a gene not previously associated with pathophysiology. These results were validated by real-time polymerase chain reaction immunohistochemistry studies, PBEF protein levels significantly...
Excessive mechanical stress is a key component of ventilator-associated lung injury, resulting in profound vascular leak and an intense inflammatory response. To extend our vitro observations concerning the barrier-protective effects lipid growth factor sphingosine 1-phosphate (Sph 1-P), we assessed ability Sph 1-P to prevent regional pulmonary edema accumulation clinically relevant rodent canine models acute injury induced by combined intrabronchial endotoxin administration high tidal...
<h3>Importance</h3> Electronic patient-reported outcomes (ePROs) may have the potential to improve cancer care delivery by enhancing patient quality of life, reducing acute visits, and extending overall survival. However, optimal cadence ePRO assessments is unknown. <h3>Objective</h3> To determine response preferences clinical value associated with a daily for ePROs patients receiving antineoplastic treatment. <h3>Design, Setting, Participants</h3> This improvement study adult undergoing...
Xe-enhanced computed tomography (CT; Xe-CT) is a method for the noninvasive measurement of regional pulmonary ventilation in intact subjects, determined from washin and washout rates radiodense, nonradioactive gas Xe, as measured serial CT scans. We used Xe-CT method, along with other quantitative measurements, to investigate distribution lung air content healthy, anesthetized, mechanically ventilated dogs prone supine postures. Vertical gradients were five mongrel both postures at four...
Objective: a) Characterize how ventilator and patient variables affect tidal volume during high-frequency oscillatory ventilation; b) measure volumes in adults with acute respiratory distress syndrome ventilation. Design: Observational study. Setting: Research laboratory medical intensive care unit. Patients: Test lung patients syndrome. Interventions: Using a previously validated hot wire anemometer placed series Sensormedics 3100B ventilator, an endotracheal tube, test lung, was measured...
Studies and applications of high-frequency ventilation (HFV) are often performed under conditions controlled mean airway pressure (Paw). In the present study we tested assumption that controlling Paw adequately controls lung volume during HFV by investigating relationship between a reliably measured alveolar (Palv) lungs healthy dogs. We minimized errors measurement due to Bernoulli effect various technical factors appropriate choice transducers, amplifiers, site. Palv was estimated clamping...
Computer tomography (CT) imaging techniques permit the noninvasive measurement of regional lung function. Regional specific volume change (sVol), determined from in density over a tidal breath, should correlate with ventilation and expansion measured other techniques. sVol was validated against xenon (Xe)-CT-specific (sV) four anesthetized, intubated, mechanically ventilated sheep. Xe-CT used expiratory gated axial scanning during washin washout 55% Xe. changes tissue (H, houndsfield units)...
Acute lung injury is characterized by heterogeneity of regional mechanical properties, which thought to be correlated with disease severity. The feasibility using respiratory input impedance (Z(rs)) and computed tomographic (CT) image registration for assessing parenchymal was evaluated. In six dogs, measurements Z(rs) before after oleic acid at various distending pressures were obtained, followed whole CT scans. Each spectrum fit a model incorporating variable distributions compliances....
Patients with septic shock are at increased risk of myocardial dysfunction. However, the left ventricular ejection fraction (EF) typically remains preserved in shock. Strain measurement using speckle-tracking echocardiography may quantify abnormalities function not detected by conventional echocardiography. To investigate whether results greater strain changes than sepsis alone, we evaluated patients and shock.We prospectively identified 35 15 sepsis. These underwent serial transthoracic...
<h3>Importance</h3> Increasingly complex surgical procedures are being performed in the outpatient setting, increasing burden on patients and caregivers to manage their postoperative symptoms. Electronic patient-reported symptom tracking may reduce this help distinguish between expected symptoms those requiring intervention. <h3>Objective</h3> To determine whether electronic reporting with clinical alerts for 10 days after ambulatory cancer surgery is associated a reduction potentially...
BACKGROUND: We describe the implementation of enhanced recovery after surgery (ERAS) programs designed to minimize postoperative nausea and vomiting (PONV) pain reduce opioid use in patients undergoing selected procedures at an ambulatory cancer center. Key components ERAS included preoperative patient education regarding course, liberal hydration, standardized PONV prophylaxis, appropriate intraoperative fluid management, multimodal analgesia all stages. METHODS: retrospectively reviewed...
Human acute lung injury is characterized by heterogeneous tissue involvement, leading to the potential for extremes of mechanical stress and when ventilation, required support critically ill patients, employed. Our goal was establish whether regional cellular responses these disparate local conditions could be determined as a novel approach toward understanding mechanism development ventilator-associated injury. We utilized cross-species genomic microarrays in unilateral model anesthetized...
Objective: We implemented routine daily electronic monitoring of patient-reported outcomes (PROs) for 10 days after discharge ambulatory cancer surgery, with alerts to clinical staff worrying symptoms. sought determine whether enhancing this by adding immediate automated normative feedback patients regarding expected symptoms would further improve the patient experience. Summary Background Data: PRO reduces symptom severity in patients. In it potentially avoidable urgent care center (UCC)...
The heterogeneous pattern of acute lung injury (ALI) predisposes patients to ventilator-associated injury. Currently, there is no simple technique that can reliably quantify heterogeneity during the dynamic conditions mechanical ventilation. Such a may be use in optimizing ventilatory parameters such as rate, tidal volume, or positive end-expiratory pressure.To determine impact on respiratory mechanics, authors measured impedance (Zrs), expressed resistance (Rrs) and elastance (Ers), 11...
To better understand strategies for recruiting and maintaining lung volume in acute injury, we examined relationships between steady-state cumulative cyclic recruitment/derecruitment history the quasi-static pressure-volume curve, an animal saline lavage injury model. Small-volume tidal loops performed after inflation from functional residual capacity demonstrated incremental, recruitment only if peak pressure achieved exceeded at which compliance increased (Pflex) on whereas deflation total...