A5028205792- Proteoglycans and glycosaminoglycans research
- Glycosylation and Glycoproteins Research
- Protease and Inhibitor Mechanisms
- Cell Adhesion Molecules Research
- Peptidase Inhibition and Analysis
- Fibroblast Growth Factor Research
- Connective tissue disorders research
- Polysaccharides Composition and Applications
- Carbohydrate Chemistry and Synthesis
- HER2/EGFR in Cancer Research
- Cancer, Hypoxia, and Metabolism
- Estrogen and related hormone effects
- Cancer Cells and Metastasis
- Chemokine receptors and signaling
- Multiple Myeloma Research and Treatments
- Osteoarthritis Treatment and Mechanisms
- Bone health and treatments
- Signaling Pathways in Disease
- Aortic aneurysm repair treatments
- Testicular diseases and treatments
- PI3K/AKT/mTOR signaling in cancer
- Bone Metabolism and Diseases
- TGF-β signaling in diseases
- Tissue Engineering and Regenerative Medicine
- Histone Deacetylase Inhibitors Research
University of Patras
2015-2024
Princess Nourah bint Abdulrahman University
2023-2024
Ludwig Cancer Research
2012
Science for Life Laboratory
2012
Uppsala University
2012
Skåne University Hospital
2010
Lund University
2010
Karolinska Institutet
2001-2006
Karolinska University Hospital
2006
Pammakaristos Hospital
2000
The 17β-estradiol (E2)/estrogen receptor alpha (ERα) signaling pathway is one of the most important pathways in hormone-dependent breast cancer. E2 plays pivotal roles cancer cell growth, survival, and architecture as well gene expression regulatory mechanisms. In this study, we established stably transfected MCF-7 cells by knocking down ERα (designated MCF-7/SP10 + cells), using specific shRNA lentiviral particles, compared them with control (MCF-7/c). Interestingly, silencing strongly...
Epithelial–mesenchymal transition (EMT) is a developmental program, which can be adopted by cancer cells to increase their migration and ability form metastases. Transforming growth factor β (TGFβ) well-studied inducer of EMT. We demonstrate that TGFβ potently stimulates hyaluronan synthesis via upregulation synthase 2 (HAS2) in NMuMG mammary epithelial cells. This stimulatory effect requires the kinase active type I receptor dependent on Smad signaling activation p38 mitogen-activated...
Progression of breast cancer implicates the degradation extracellular matrix (ECM) by metallo-proteinases (MMPs), a process with important consequences on growth and invasiveness cells in adjacent distant sites. The isoflavone, genistein--a natural inhibitor protein tyrosine kinase pathway--inhibits wide range vitro. aim this study was to investigate: i) expression mRNAs encoded for MMPs their endogenous inhibitors (TIMPs) associated pathogenesis metastatic potential cells; ii) effect...
Although the biological significance of proteoglycans (PGs) has previously been highlighted in multiple myeloma (MM), little is known about serglycin, which a hematopoietic cell granule PG. In this study, we describe expression and highly constitutive secretion serglycin several MM lines. Serglycin messenger RNA was detected six PGs were purified from conditioned medium four lines, substituted with 4-sulfated chondroitin sulfate identified as predominant Flow cytometry confocal microscopy...