A5087911455- vaccines and immunoinformatics approaches
- SARS-CoV-2 and COVID-19 Research
- Bacteriophages and microbial interactions
- Immunotherapy and Immune Responses
- Hepatitis B Virus Studies
- Microbial infections and disease research
- Vector-borne infectious diseases
- Viral gastroenteritis research and epidemiology
- Toxin Mechanisms and Immunotoxins
- Monoclonal and Polyclonal Antibodies Research
- COVID-19 Clinical Research Studies
- Pneumonia and Respiratory Infections
- Parasitic Infections and Diagnostics
- Computational Drug Discovery Methods
- Entomopathogenic Microorganisms in Pest Control
- Synthesis and biological activity
- Peptidase Inhibition and Analysis
- Animal Virus Infections Studies
- Animal Disease Management and Epidemiology
- Vector-Borne Animal Diseases
- Research on Leishmaniasis Studies
- Transgenic Plants and Applications
- Virus-based gene therapy research
- Clostridium difficile and Clostridium perfringens research
- Plant Virus Research Studies
Razi Vaccine and Serum Research Institute
2016-2025
Agricultural Research & Education Organization
2017-2025
Semnan University of Medical Sciences
2022
Institut Pasteur
2022
University of Tehran
2013-2016
Aja University of Medical Sciences
2015
Tehran University of Medical Sciences
2010-2011
The RNA-dependent RNA polymerase (RdRp) and 3C-like protease (3CLpro) from SARS-CoV-2 play crucial roles in the viral life cycle are considered most promising targets for drug discovery against SARS-CoV-2. In this study, FDA-approved drugs were screened to identify probable anti-RdRp 3CLpro inhibitors by molecular docking approach. number of ligands selected PubChem database NCBI screening was 1760. Ligands energy minimized using Open Babel. RdRp protein sequences retrieved database. For...
Abstract Background Streptococcus pneumoniae (Pneumococcus) has remained a leading cause of fatal infections such as pneumonia, meningitis, and sepsis. Moreover, this pathogen plays major role in bacterial co-infection patients with life-threatening respiratory virus diseases influenza COVID-19. High morbidity mortality over one million cases, especially very young children the elderly, are main motivations for pneumococcal vaccine development. Due to limitations currently marketed...
Streptococcus pneumoniae is the leading reason for invasive diseases including pneumonia and meningitis, also secondary infections following viral respiratory such as flu COVID-19. Currently, serotype-dependent vaccines, which have several insufficiency limitations, are only way to prevent pneumococcal infections. Hence, it plain need an alternative effective strategy prevention of this organism. Protein-based vaccine involving conserved protein antigens with different roles in virulence...
Cordia myxa is a plant which used in tropical regions of the world. Analgesic and anti-inflammatory effect fruit this medicinal was investigated mice. Hydro-alcoholic extract it prepared by maceration method. Formalin test conducted six groups mice (6 animals each group) acetic acid another mice). Groups one to were administered normal saline, oral indomethacin, intraperitoneal tramadol, 100 mg kg(-1) extract, 200 respectively. The duration foot lickings calculated formalin- (1st) group...
Hydro-alcoholic fruit extract of Cordia myxa was considerably effective on curing acute inflammation in mouse model. Previous studies suggested significant anti-inflammatory activities as well potential anticancer agent α-amyrins seeds. Inhibition Cyclooxygenase-2 (COX-2) and 5-Lipooxygenase (5-LOX) is cancer prevention therapeutics although this inhibition with chemo-drugs has its own side-effects. It shown that these enzymes pathways are related to several cancers including colon, breast...
The enzyme-linked immunosorbent assay (ELISA) technique can play an important role in the early detection of fascioliasis. However, they have some diagnostic limitations, including cross-reaction with other helminths. It seems that combination recombinant parasite proteins as antigen reduce these problems. Hence, present study was aimed to design and confirm antigenic multi-epitope (rMEP) construct three protein epitopes (linear conformational B-cell epitopes) using immunoinformatic tools....
The present investigation was performed to determine the stability of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) under several industrial processing situations in dairies, including pasteurization, freezing, and storage acidic conditions. Ten treatments were selected, high-temperature short-time (HTST)-pasteurized low-fat milk, low-temperature long-time-pasteurized extended shelf life (ESL)-pasteurized HTST-pasteurized full-fat LTLT-pasteurized ESL-pasteurized pasteurized...
Acinetobacter baumannii is a Gram-negative bacterium that has recently been identified as leading nosocomial pathogen. Infections by this pathogen result in significant mortality due to antibiotic resistance. An effective vaccine would help alleviate the burden of disease incurred pathogen; however, there are currently no licensed vaccines offering protection against infection.
 In study, considering fact outer membrane protein A one most promising candidates, we predicted T cell and B...
Background The transcription factor SALL4 is associated with embryonic pluripotency and has proposed as a novel immunohistochemistry (IHC) marker for diagnosing germ cell tumors. comprises three isoforms, SALL4-A being the full-length isoform. Studying its isoforms could revolutionize testicular cancer prognosis subtype differentiation.