Introduction. The treatment of polytrauma in children requires identifying the signs that characterize severity acute period and quantifying priorities parameters. Collectively, these reflect direction drift leading pathophysiological manifestations at each stage patient withdrawal program from a state severe shock.
 Purpose. This study uses discriminant analysis to clarify tactics with first days overcoming its consequences. It is based on pathogenetically sound idea observed...

The pathogenesis of a number diseases is characterized by violation the regulation bone homeostasis, with progressive development osteodestruction. At same time, an active study mechanisms leading to shift in balance osteoreparative and osteoresorption directions osteogenesis underway. determination molecular cellular patterns affecting dynamics changes metabolism significant task among wide range specialists. Such research works allow us propose algorithms for targeted therapeutic effects...

Background There is currently no pathogenetically based treatment for aseptic necrosis of the femoral head. One most promising areas possible targeted therapy use genetically engineered drugs, including monoclonal blockers proinflammatory cytokines, aimed at inhibiting inflammation and indirectly reducing activity osteodestruction. The aim work to evaluate effectiveness IL-6 blocker in course head an experiment. Purpose Evaluate preliminary results Materials methods Surgical induction was...

Bone tissue is a dynamic structure with metabolic function. The maintenance of bone homeostasis carried out due to the continuous process its renewal, remodeling. At same time, number pathological processes, such as ischemic catastrophe, can lead violation balance maintaining constancy structure. One these diseases aseptic necrosis femoral head. presented study analyzes dynamics expression genes involved in homeostasis, changes histological picture during development head laboratory rats...

Aim. To develop an animal model of femoral head aseptic necrosis for studying Legg–Calvé–Perthes disease. Materials and Methods. induce the development necrosis, we used Wistar rats (n = 8) which suffered from combined hypoperfusion increased intra-articular pressure in hip joint. Having employed isoflurane anesthesia, performed incision (≈ 3 cm length) on outer surface thigh projection joint then excised periosteum proximal third femur. A dense vicryl ligature was applied around neck to...

Introduction: to analyze pathological processes in a patient with multiple trauma. Classification and structuring are not taken into account, as they require estimation of condition severity dynamics process. It is frequently impossible do so. In every specific case, it necessary structure The Injury Severity Score (ISS) system useful this consists combination, certain quantitative qualitative estimate which makes possible patient’s at early pre-hospital stage adjust treatment. Purpose: make...

Aim. To compare the foot position in asymptomatic children and those who received conservative or surgical because of flatfoot. Materials Methods. We consecutively recruited three patient groups: 112 healthy children, 74 with a pronation position, 80 an overpronation foot. The Foot Posture Index (FPI – 6) was used for clinical examination. Visual manual tests were to determine mobility joints. X-ray performed standard lateral projection load; if necessary, multislice computed tomography...

BACKGROUND: The problem of anti-shock measures and stabilization the general condition affected children with polytrauma at stage intensive care is an extremely urgent issue in pediatric traumatology. Various aspects, such as determining most sensitive prognostic scale for assessing severity polytrauma, clinical laboratory predictors changes vector development course traumatic disease direction thanatogenic orientation, remain actively discussed among clinicians. АIM: aim study to analyse...

Aim . To conduct histological analysis of femoral head avascular necrosis in Wistar rats. Materials and Methods Femoral was artificially induced 12 rats which have been euthanised at 2, 4, 6, 8 weeks postoperation (n = 3 per time point). Affected intact heads were examined by X-ray examination, haematoxylin eosin staining, scanning electron microscopy. Results examination staining showed the progressive development osteonecrosis from 2 to 6 initiation bone repair postoperation. had less...

Aseptic necrosis of the femoral head is a staged process in which osteodestruction replaced by bone repair. The outcome this disease may be characterized severe discongruence hip joint area, disability patient. Recently, research interest drawn to molecular and cellular mechanisms homeostasis disorders ways its correction. A number studies have demonstrated role nonspecific inflammation pathogenesis aseptic necrosis. However, more detailed study dynamic changes activity osteogenesis...

BACKGROUND: One of the most relevant areas study Perthes disease is search and scientific justification new targets for treatment osteodestructive processes. At same time, an important link in regulation bone homeostasis cytokine system that affects processes differentiation activation osteoclasts through RANK-RANKL-OPG signaling pathway. Inhibition biological action proinflammatory cytokines early stages aseptic necrosis a promising direction antiresorptive therapy. АIM: To assess...

Aim. To study the molecular and cellular features of femoral head avascular necrosis in rat model. Materials Methods. Femoral was surgically induced 8 rats with 4-week follow-up. Then, animals have been euthanised, we performed gross, radiological, histological examination intact contralateral heads. Systemic inflammation assessed using enzyme-linked immunosorbent assay, pro-inflammatory cytokines (interleukin-1β, interleukin-6, tumor factor α). The proteomic profile healthy necrotic heads...

INTRODUCTION: The introduction of minimally invasive methods in clinical practice has significantly expanded the indications for surgical treatment bone fractures children. method osteosynthesis with titanium elastic nails is widely used at age 7 to 14 years and many advantages. At same time, elastic-stable a number probable complications limitations. AIM: To analyze intramedullary children different categories. MATERIALS AND METHODS: results 98 long bones lower extremities were analyzed....

Background. LeggCalvePerthes disease (LCPD) is an idiopathic avascular femoral head osteonecrosis. The early stage associated with the development of synovitis hip joint linked to overproduction factors induced by hypoxia as well interleukin (IL)-6. Associations individual polymorphic variants cytokine genes LCPD have been shown. Moreover, alterations in regulatory cascade are considered important link pathogenesis synovial inflammation stages LCPD. Accordingly, this process may be a certain...