A5040915187- Muscle metabolism and nutrition
- Amino Acid Enzymes and Metabolism
- Trace Elements in Health
- Iron Metabolism and Disorders
- Protein Hydrolysis and Bioactive Peptides
- Protein purification and stability
- Folate and B Vitamins Research
- Plant Micronutrient Interactions and Effects
- Glycosylation and Glycoproteins Research
- Diet and metabolism studies
- Phytoestrogen effects and research
- Sulfur Compounds in Biology
- Monoclonal and Polyclonal Antibodies Research
- Cardiovascular Health and Disease Prevention
- Rheumatoid Arthritis Research and Therapies
- Infant Nutrition and Health
- Fatty Acid Research and Health
- Meat and Animal Product Quality
- Advanced Chemical Sensor Technologies
- Diet, Metabolism, and Disease
- Nutritional Studies and Diet
- Digestive system and related health
- Proteins in Food Systems
- Cassava research and cyanide
- Sirtuins and Resveratrol in Medicine
Clinical Nutrition Research Centre
2022-2023
Abbott (Singapore)
2022-2023
Abbott Nutrition (United States)
2009-2021
Abbott (United States)
2009-2021
Ross Laboratories (United States)
2003-2021
Nutrition 21 (United States)
2020
Abbott (United Kingdom)
2011-2014
Abbott (Canada)
2013
Wrightington Hospital
1993
Royal Preston Hospital
1982
Abstract Cocoa flavanols protect humans against vascular disease, as evidenced by improvements in peripheral endothelial function, likely through nitric oxide signalling. Emerging evidence also suggests that flavanol-rich diets cognitive aging, but mechanisms remain elusive. In a randomized double-blind within-subject acute study healthy young adults, we link these two lines of research showing, for the first time, flavanol intake leads to faster and greater brain oxygenation responses...
Abstract Isoflavones are biologically active compounds occurring naturally in a variety of plants, with relatively high levels found soybeans. Twelve laboratories participated collaborative study to determine the aglycon isoflavone content 8 test samples soy and foods containing soy. The analytical method for determination isoflavones incorporates mild saponification step that reduces number analytes measured permits quantitation versus commercially available, stable reference standards....
OBJECTIVES--To examine the relation between rheumatoid arthritis (RA) and bronchiectasis (BR). METHODS--Disease activity, outcome, extra-articular manifestations, laboratory features were compared in 32 patients with BR RA (RA-BR group), matched without (RA 31 but (BR group). RESULTS--In 30 of (94%) RA-BR, preceded RA. There was no functional or radiological difference RA-BR groups, except for xerophthalmia, which more common than RA, there features. CONCLUSIONS--Bronchiectasis does not lead...
Mental stress has been shown to induce cardiovascular events, likely due its negative impact on vascular function. Flavanols, plant-derived polyphenolic compounds, improve endothelial function and blood pressure (BP) in humans, however their effects during are not known. This study examined the of acute intake cocoa flavanols stress-induced changes In a randomised, controlled, double-blind, cross-over intervention study, 30 healthy men ingested flavanol beverage (high-flavanol: 150 mg vs....
Preventing muscle wasting in certain chronic diseases including cancer is an ongoing challenge. Studies have shown that polyphenols derived from fruits and vegetables shows promise reducing loss cellular animal models of wasting. We hypothesized plums (Prunus domestica) could anabolic anti-catabolic benefits on skeletal muscle. The effects a polyphenol-enriched plum extract (PE60) were evaluated vitro C2C12 Colon-26 cells. Data analyzed using one-way ANOVA we found treatment myocytes with...
Abstract The rate of vitamin B12 loss was 3X greater in heated, chocolate-flavoured milk than unflavoured milk. Studies stability the presence cocoa powder components were performed to identify reactive agents. Cocoa polyphenols with a strong capacity both for reduction and peroxide generation accelerated destruction as much 20-fold vs. without capacities. Polyphenols capacities include polyphenol (+)-catechin oligomers thereof, but also structurally related gallic acid, caffeic acid...
Abstract An alkaline hydrolysis/liquid chromatography (LC) method was developed for determination of isoflavones in ready-to-feed soy-based infant formula. The consists a 15 min methanol extraction, 10 hydrolysis, HCl neutralization, gravity filtration, aqueous dilution, and 50 LC analysis with UV detection at 262 250 nm to quantify 6 isoflavone analytes: daidzin, glycitin, genistin, daidzein, glycitein, genistein. concentration averages commercial batches (μg aglycone/g formula) were 6.12 ±...
Total glutamine concentrations in commercial nutritional products have been determined by enzymatic hydrolysis followed HPLC quantification of free and pyroglutamic acid. Hydrolysis was accomplished a published three-enzyme (Pronase, leucine aminopeptidase, prolidase), 20-h/37 degrees C digestion. Glutamine as its FMOC derivative reverse phase HPLC-fluorescence, acid directly organic HPLC-UV. Approximately 4.11% the released is converted to during 20-h Experimental ratios enzyme glutamic +...
Summary The addition of NaFe EDTA at only 5% total iron to ferric pyrophosphate‐fortified Ultra Rice ® increased the in vitro soluble ten‐fold. formulated with 2–7% iron, or Na 2 ·2H O 0.5× equivalents, seven‐ thirty‐fold. colour batches was acceptable through 20 weeks 21 °C, but stability needs be evaluated under authentic storage conditions. Although 34–46% initial vitamin A remained after extrusion, 18‐week 30 °C/70% relative humidity, and simulated cooking, there were indications that...
A method was developed for the direct, simultaneous determination of acesulfame and sucralose in oral electrolyte maintenance solution (OEMS). Analyte separation quantitation were achieved by gradient reversed-phase liquid chromatography (LC) UV absorbance at 192 nm, respectively. Detection a second wavelength, 214 used to check peak purity; 20 microL OEMS injected without preparation or dilution. System linearity demonstrated as nm area versus analyte concentration 80-120% sweetener...