A5087586661- Muscle metabolism and nutrition
- HIV-related health complications and treatments
- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Nutrition and Health in Aging
- HIV Research and Treatment
- Mitochondrial Function and Pathology
- HIV/AIDS drug development and treatment
- Diabetes Treatment and Management
- Muscle Physiology and Disorders
- Pancreatic function and diabetes
- Metabolism, Diabetes, and Cancer
- Metabolism and Genetic Disorders
- Cardiovascular Function and Risk Factors
- Clinical Nutrition and Gastroenterology
- Pharmacology and Obesity Treatment
- Adipokines, Inflammation, and Metabolic Diseases
- Liver Disease Diagnosis and Treatment
- Diabetes Management and Research
- Dietary Effects on Health
- Cardiovascular Disease and Adiposity
- Physical Activity and Health
- Neuropeptides and Animal Physiology
- Hormonal and reproductive studies
Washington University in St. Louis
2015-2024
University of Missouri–St. Louis
2023
Barnes-Jewish College
2022
Center for Human Genetics
2012-2018
Atkins (United States)
2011-2016
Saint Louis University
2015
Nutritional Research Foundation
2012
Southern Illinois University Edwardsville
2009
Increased dietary LCn−3PUFA (long-chain n−3 polyunsaturated fatty acid) intake stimulates muscle protein anabolism in individuals who experience loss due to aging or cancer cachexia. However, it is not known whether LCn−3PUFAs elicit similar anabolic effects healthy individuals. To answer this question, we evaluated the effect of 8 weeks supplementation (4 g Lovaza®/day) nine 25–45-year-old subjects on rate synthesis (by using stable isotope-labelled tracer techniques) and activation...
Some studies have suggested that in people with type 2 diabetes, Roux-en-Y gastric bypass has therapeutic effects on metabolic function are independent of weight loss.
High-protein (HP) intake during weight loss (WL) therapy is often recommended because it reduces the of lean tissue mass. However, HP could have adverse effects on metabolic function, protein ingestion postprandial insulin sensitivity. In this study, we compared ∼10% WL with a hypocaloric diet containing 0.8 g protein/kg/day and 1.2 muscle action in postmenopausal women obesity. We found that reduced WL-induced decline mass by ∼45%. also prevented improvements signaling insulin-stimulated...
Abdominal obesity is associated with metabolic risk factors for coronary heart disease (CHD). Although we previously found that using liposuction surgery to remove abdominal subcutaneous adipose tissue (SAT) did not result in benefits, it possible postoperative inflammation masked the beneficial effects. Therefore, this study provides a long-term evaluation of cohort subjects from our original study. Body composition and CHD, including oral glucose tolerance, insulin resistance, plasma lipid...
The effect of the female sex steroids, estradiol and progesterone, on muscle protein turnover is unclear. Therefore, it unknown whether changes in hormonal milieu throughout life span women contribute to mass (eg, age associated loss).The objective this study was provide a comprehensive evaluation hormones synthesis gene expression growth-regulatory factors [ie, myogenic differentiation 1 (MYOD1), myostatin (MSTN), follistatin (FST), forkhead box O3 (FOXO3)].We measured basal rate genes 12...
Although there appear to be no differences in muscle protein turnover young and middle aged men women, we have reported significant the rate of synthesis between older adult women. This suggests that aging may affect differently women.We measured skeletal fractional (FSR) by using stable isotope-labeled tracer methods during basal postabsorptive conditions a hyperaminoacidemic-hyperinsulinemic-euglycemic clamp eight (25-45 y), ten women old (65-85 y) y).The FSR was not different (0.040 ±...
Increased plasma branched-chain amino acid concentrations are associated with insulin resistance, and intravenous infusion blunts insulin-mediated glucose disposal. We tested the hypothesis that protein ingestion impairs disposal by leucine-mediated mTOR signaling, which can inhibit AKT. measured muscle p-mTORSer2448, p-AKTSer473, p-AKTThr308 in 22 women during a hyperinsulinemic-euglycemic clamp procedure without concomitant of whey (0.6 g/kg fat-free mass; n = 11) or leucine matched amount...
Dietary fish oil-derived n-3 PUFA supplementation can increase muscle mass, reduce oxygen demand during physical activity, and improve function (muscle strength power, endurance) in people. The results from several studies conducted animals suggest that the anabolic performance-enhancing effects of are at least part transcriptionally regulated. effect therapy on transcriptome people is unknown. In this study, we used biopsy samples collected a recently completed randomized controlled trial...
Abstract Integrase strand transfer inhibitor (INSTI)-based antiretroviral therapy (ART) is first line for treatment of people with human immunodeficiency virus (PWH). Emerging data suggest the possibility adverse metabolic effects these medications. We describe 3 cases in which PWH developed hyperglycemia and ketoacidosis within months being switched to bictegravir-based ART.
Men have more muscle than women, but most studies evaluating sex differences in protein metabolism been unable to discern sexual dimorphism basal turnover rates young and middle-aged adults. We hypothesized that the anabolic response nutritional stimuli (i.e., amino acids insulin) would be greater young/middle-aged men women. therefore measured of synthesis (MPS) 16 healthy individuals [8 8 matched for age (mean ± SE: 37.7 1.5 yr) body mass index (25.2 0.7 kg/m 2 )] after an overnight fast...
OBJECTIVE Ginseng and its active component, ginsenoside Re, are popular herbal products that advocated for treatment of diabetes. The purpose this study was to determine whether ginseng or Re improves β-cell function insulin sensitivity (IS) in insulin-resistant subjects. RESEARCH DESIGN AND METHODS Overweight obese subjects (BMI = 34 ± 1 kg/m2) with impaired glucose tolerance newly diagnosed type 2 diabetes were randomized 30 days root extract (8 g/day), (250–500 mg/day), placebo. β-Cell...
Glucose-dependent insulinotropic polypeptide (GIP) potentiates glucose-stimulated insulin secretion (GSIS). This response is blunted in type 2 diabetes (T2DM). Xenin-25 a 25-amino acid neurotensin-related peptide that amplifies GIP-mediated GSIS hyperglycemic mice. study determines if xenin-25 humans with normal glucose tolerance (NGT), impaired (IGT), or T2DM. Each fasting subject received graded infusions to progressively raise plasma concentrations, along vehicle alone, GIP, xenin-25, GIP...
The aim of the current study (Clinical trial reg. no. NCT02715193, clinicaltrials.gov) was to efficacy and safety REMD-477, a glucagon receptor antagonist, in type 1 diabetes. This randomized controlled which 21 patients with diabetes were enrolled. Glycaemic control insulin use evaluated outpatient inpatient settings, before after single 70-mg dose REMD-477 (half-life 7-10 days) or placebo. Inpatient 26% (95% CI, 47%, 4%) lower day dosing than placebo (P = .02). Continuous glucose...
It is not known whether calorie restriction (CR) has additive benefits to those from exercise (EX)-induced weight loss. We hypothesized that loss CR and EX (CREX) improves insulin sensitivity more than matched induced by or alone the incretin system may be involved in adaptations CR.Sedentary, overweight men women (n = 52, 45-65 years of age) were randomized undergo 6-8% using CR, EX, CREX. Glucose, insulin, C-peptide, sensitivity, hormones (glucagon-like peptide 1 [GLP-1] glucose-dependent...
Hypertriglyceridemia is common in individuals with human immunodeficiency (HIV) infection, but the mechanisms responsible for increased plasma triglyceride (TG) concentrations are not clear. We evaluated fatty acid and VLDL-TG kinetics during basal conditions a glucose infusion that resulted typical postprandial insulin six men HIV-dyslipidemia [body mass index (BMI): 28 ± 2 kg/m ] healthy (BMI: 26 ). secretion palmitate rate of appearance (R ) were measured by using stable-isotope-labeled...
Persistent vascular inflammation has been implicated as an important cause for a higher prevalence of cardiovascular disease (CVD) in HIV-infected adults. In several populations at high risk CVD, 18Fluorodeoxyglucose (18FDG) uptake quantified using 3D-positron emission-computed tomography (PET-CT) used molecular level biomarker the presence metabolically active proinflammatory macrophages rupture-prone early atherosclerotic plaques. We hypothesized that 18FDG PET-CT imaging would detect...
Phosphatidylcholine and deoxycholate (PC-DC) injections are a popular nonsurgical method to eliminate unwanted fat. The safety efficacy of this approach is uncertain.
Abstract Barth syndrome ( BTHS ) is an X‐linked condition characterized by altered cardiolipin metabolism and cardioskeletal myopathy. We sought to compare cardiac skeletal muscle bioenergetics in children, adolescents, young adults with unaffected controls examine their relationships function exercise capacity. Children/adolescents n = 20) children/adolescent adult control participants 23, total 43) underwent 31 P magnetic resonance spectroscopy P‐ MRS of the lower extremity (calf) heart...