A5101815264- Advanced MRI Techniques and Applications
- Cardiovascular Function and Risk Factors
- Atomic and Subatomic Physics Research
- Cardiac Imaging and Diagnostics
- Neuroscience and Neuropharmacology Research
- Advanced NMR Techniques and Applications
- Liver Disease Diagnosis and Treatment
- Cardiovascular and exercise physiology
- Osteoarthritis Treatment and Mechanisms
- Electron Spin Resonance Studies
- Advanced Neuroimaging Techniques and Applications
- Sports Performance and Training
- Diet and metabolism studies
- Mitochondrial Function and Pathology
- Metabolism and Genetic Disorders
- Functional Brain Connectivity Studies
- Liver Disease and Transplantation
- Parkinson's Disease Mechanisms and Treatments
- Muscle activation and electromyography studies
- Quantum, superfluid, helium dynamics
- Muscle metabolism and nutrition
- Lanthanide and Transition Metal Complexes
- Musculoskeletal pain and rehabilitation
- Hepatocellular Carcinoma Treatment and Prognosis
- Bone and Joint Diseases
Auburn University
2017-2025
University of Alabama at Birmingham
2024
Washington University in St. Louis
2006-2019
Government Medical College
2019
Mallinckrodt (United States)
2008-2015
Sher-i-Kashmir Institute of Medical Sciences
2002
Massachusetts Institute of Technology
1996-1999
Beth Israel Deaconess Medical Center
1997
Despite the compelling need mandated by prevalence and morbidity of degenerative cartilage diseases, it is extremely difficult to study disease progression therapeutic efficacy, either in vitro or vivo (clinically). This partly because no techniques have been available for nondestructively visualizing distribution functionally important macromolecules living cartilage. Here we describe validate a technique image glycosaminoglycan concentration ([GAG]) human magnetic resonance imaging (MRI)....
Abstract Glycosaminoglycans (GAGs) are the main source of tissue fixed charge density (FCD) in cartilage, and lost early arthritic diseases. We tested hypothesis that, like Na + , charged contrast agent Gd‐DTPA 2‐ (and hence proton T 1 ) could be used to measure FCD GAG concentration. NMR spectroscopy studies cartilage explants demonstrated that there was a strong correlation ( r > 0.96) between presence sodium concentrations. An ideal one‐compartment electrochemical (Donnan) equilibrium...
PURPOSE: To investigate the feasibility of applying magnetic resonance (MR) imaging with use an anionic compound, Gd(DTPA)2- (gadolinium diethylenetriamine-pentaacetic acid), for measuring glycosaminoglycan concentration in human cartilage clinical studies. MATERIALS AND METHODS: Penetration into was monitored through sequential T1-calculated images obtained after intraarticular (n = 2) or intravenous injection. T1-weighted and image series were then seven volunteers (nine knees) penetration...
Purpose To evaluate the safety of hyperpolarized helium 3 (3He) magnetic resonance (MR) imaging. Materials and Methods Local institutional review board approval informed consent were obtained. Physiologic monitoring data obtained before, during, after 3He MR imaging in 100 consecutive subjects (57 men, 43 women; mean age, 52 years ± 14 [standard deviation]). The inhaled 1–3 L a gas mixture containing 300–500 mL 0–2700 N2 held their breath for up to 15 seconds during Heart rate rhythm oxygen...
Excessive cardiac long-chain fatty acid (LCFA) metabolism/storage causes cardiomyopathy in animal models of type 2 diabetes. Medium-chain acids (MCFAs) are absorbed and oxidized efficiently. Data diabetes suggest MCFAs may benefit the heart.Our objective was to test effects an MCFA-rich diet vs LCFA-rich on plasma lipids, steatosis, function patients with diabetes.This a double-blind, randomized, 2-week matched-feeding study.The study included ambulatory general community.Sixteen patients,...
Abstract The most common MR‐based approach to noninvasively measure brain temperature relies on the linear relationship between 1 H MR resonance frequency of tissue water and tissue's temperature. Herein we provide accurate in vivo assessment existing thus far such a relationship. It was derived by acquiring spectra from rat using high field (11.74 Tesla [T]) MRI scanner single‐voxel spectroscopy technique based LASER pulse sequence. Data were analyzed three different methods estimate...
Abstract Barth syndrome ( BTHS ) is an X‐linked condition characterized by altered cardiolipin metabolism and cardioskeletal myopathy. We sought to compare cardiac skeletal muscle bioenergetics in children, adolescents, young adults with unaffected controls examine their relationships function exercise capacity. Children/adolescents n = 20) children/adolescent adult control participants 23, total 43) underwent 31 P magnetic resonance spectroscopy P‐ MRS of the lower extremity (calf) heart...
Identification of individuals at high risk for rapid progression motor and cognitive signs in Parkinson disease (PD) is clinically significant. Postural instability gait dysfunction (PIGD) are associated with greater deterioration. We examined the relationship between baseline clinical factors development postural using 5-year longitudinal de-novo idiopathic data (n = 301) from Parkinson's Progressive Markers Initiative (PPMI). Logistic regression analysis revealed features future...
Accumulation of triglycerides (TG) in heart tissue has been associated with changes left ventricular function. Proton magnetic resonance spectroscopy is currently the only noninvasive vivo method to measure myocardial content. The primary aim this study was determine if these measurements are specific human subjects. Thus, proton were conducted on orthotopic transplant patients (n = 8) immediately before they underwent routine biopsies and ex made endomyocardial biopsy samples. correlation...
Abstract Background Previous findings in psychosis have revealed mixed on glutamate (Glu) levels the dorsal anterior cingulate cortex (dACC). Factors such as illness chronicity, methodology, and medication status impeded a more nuanced evaluation of Glu psychosis. The goal this longitudinal neuroimaging study was to investigate role antipsychotics dACC antipsychotic-naïve first-episode (FEP) patients. Methods We enrolled 117 healthy controls (HCs) 113 FEP patients for study. 3T proton...
Barth syndrome (BTHS) is an ultra-rare, X-linked recessive disorder characterized by cardio-skeletal myopathy, exercise intolerance, and growth delay. Oxygen uptake during peak (VO2peak) has been shown to be severely limited in individuals with BTHS however; the trajectory of VO2peak from childhood young adulthood unknown. The objective this study was describe through BTHS. Methods Materials: over time presented cross-sectional (n = 33 participants) a longitudinal analyses 12 participants)....
We evaluated the effects of higher-load (HL) versus (lower-load) higher-volume (HV) resistance training on skeletal muscle hypertrophy, strength, and muscle-level molecular adaptations. Trained men (
Abstract The discrete Fourier transform (FT) is a conventional method for spatial reconstruction of chemical shifting imaging (CSI) data. Due to point spread function (PSF) effects, FT leads intervoxel signal leakage (Gibbs ringing). Spectral localization by (SLIM) was previously proposed overcome this contamination. However, the existence magnetic field inhomogeneities creates an additional source leakage. It demonstrated herein that even small substantially amplify in both and SLIM...
Creatine kinase (CK) is essential for the buffering and rapid regeneration of adenosine triphosphate (ATP) in heart tissue. Herein, we demonstrate a 31P MRS protocol to quantify CK reaction kinetics human myocardium at 3 T. Furthermore, sought test–retest reliability measured metabolic parameters. The method localizes signal from using modified one-dimensional image-selected vivo spectroscopy (ISIS), time-dependent saturation transfer (TDST) approach was used measure Fifteen healthy...
The effects of type II diabetes on cardiac creatine kinase (CK) enzyme activity and/or flux are unknown. We therefore measured steady-state phosphocreatine (PCr) and adenosine triphosphate (ATP) content forward CK reaction kinetic parameters in Zucker Diabetic Fatty (ZDF) rat hearts, a research model. At baseline the PCr to ATP ratio (PCr/ATP) was significantly lower diabetic heart when compared with matched controls (1.71 ± 0.21 vs. 2.26 0.24, P < 0.01). Furthermore, rate constant (kf)...
Abstract MRI with hyperpolarized gases, 3 He, 129 Xe, 13 C, and others, has the potential to become an important diagnostic technique for clinical imaging. Due nonreversible loss of magnetization in gas imaging, choice flip angle is a major factor that influences signal intensity, hence, signal‐to‐noise ratio. Conventional automated radiofrequency (RF) calibration procedures 1 H imaging are not suitable Herein, we have demonstrated simple procedure RF magnetic resonance (MRI) gases easily...
Abstract MRI is a valuable diagnostic tool to investigate spinal cord (SC) pathology. SC can benefit from the increased signal-to-noise ratio (SNR) and contrast-to-noise (CNR) at ultra-high fields such as 7 T. However, acquisitions with routine Cartesian readouts are prone image artifacts caused by physiological motion. acquisition techniques non-Cartesian rosette help reduce motion artifacts. The purpose of this study was demonstrate feasibility high-resolution imaging using trajectory...
We examined how set-volume equated resistance training using either the back squat (SQ) or hip thrust (HT) affected hypertrophy and various strength outcomes. Untrained college-aged participants were randomized into HT (n = 18) SQ 16) groups. Surface electromyograms (sEMG) from right gluteus maximus medius muscles obtained during first session. Participants completed 9 weeks of supervised (15–17 sessions), before after which leg muscle cross-sectional area (mCSA) was assessed via magnetic...
Abstract The objective of this study is to determine characteristics patients with myofascial pain syndrome (MPS) the low back and degree which in examined can be attributed MPS. Twenty-five subjects trigger point(s) [MTrP(s)] on participated cross-sectional study. location, number, type selected MTrPs were identified by palpation verified ultrasound. Pain pressure threshold, physical function, other self-reported outcomes measured. Significant differences found Group 1 (Active), 2 (Latent),...
Feline obesity is common, afflicting ~25-40% of domestic cats. Obese cats are predisposed to many metabolic dyscrasias, such as insulin resistance, altered blood lipids, and feline hepatic lipidosis. Fibroblast Growth Factor-21 (FGF21) an endocrine hormone that mediates the fat-liver axis, in humans animals, FGF21 can ameliorate non-alcoholic fatty liver disease, obesity. Activation pathway may have therapeutic benefits for obese cats.In this preliminary cross-sectional study, ad libitum...