A5042854587- Alzheimer's disease research and treatments
- Neurobiology and Insect Physiology Research
- Health, Environment, Cognitive Aging
- Insect Utilization and Effects
- Ferroptosis and cancer prognosis
- Insect and Arachnid Ecology and Behavior
- Genetics, Aging, and Longevity in Model Organisms
- RNA modifications and cancer
- RNA Interference and Gene Delivery
- Insect Pheromone Research and Control
- DNA and Nucleic Acid Chemistry
- Mitochondrial Function and Pathology
- Advanced biosensing and bioanalysis techniques
- Biochemical Analysis and Sensing Techniques
- Metabolomics and Mass Spectrometry Studies
- Neuroscience and Neuropharmacology Research
- Diet, Metabolism, and Disease
- Olfactory and Sensory Function Studies
- Cannabis and Cannabinoid Research
- Cancer-related molecular mechanisms research
- Tryptophan and brain disorders
- Metabolism, Diabetes, and Cancer
- Cancer, Hypoxia, and Metabolism
- Folate and B Vitamins Research
- Glutathione Transferases and Polymorphisms
Salk Institute for Biological Studies
2019-2022
University of Miami
2017-2019
University of Pittsburgh
2010
Abstract Background All cells accumulate insoluble protein aggregates throughout their lifespan. While many studies have characterized the canonical disease-associated aggregates, such as those associated with amyloid plaques, additional, undefined proteins aggregate in brain and may be directly disease Methods A proteomics approach was used to identify a large subset of mild cognitively impaired (MCI) Alzheimer’s (AD) human brain. Cortical samples from control, MCI, AD patients were...
Abstract Olfaction is a key component of the multimodal approach used by mosquitoes to target and feed on humans, spreading various diseases. Current repellents have drawbacks, necessitating development more effective agents. In addition variable odorant specificity subunits, all insect receptors (ORs) contain conserved receptor co-receptor (Orco) subunit which an attractive for repellent development. Orco directed antagonists allosterically inhibit activation ORs we previously showed that...
J147 is a novel drug candidate developed to treat neurological dysfunction. Numerous studies have demonstrated the beneficial effects of in cellular and animal models disease which has led transitioning compound into human clinical trials. However, no biomarkers for its target engagement been identified. Here, we determined if specific metabolites plasma could be indicative J147's activity vivo. Plasma lipidomics data from three independent rodent were assessed along with liver one studies....
Geroprotectors are compounds that slow the biological aging process in model organisms and may therefore extend healthy lifespan humans. It is hypothesized they do so by preserving more youthful function of multiple organ systems. However, this hypothesis has rarely been tested any besides C. elegans D. melanogaster. To determine if two life-extending for Drosophila maintain a phenotype old mice, we asked had anti-aging effects both brain kidney. We utilized rapidly senescence-accelerated...
Response to volatile environmental chemosensory cues is essential for insect survival. The odorant receptor (OR) family an important class of receptors that detects molecules; guiding insects towards food, mates, and oviposition sites. ORs are odorant-gated ion channels, consisting a variable specificity subunit conserved co-receptor (Orco) subunit, in unknown stoichiometry. Orco possesses allosteric site which modulators can bind noncompetitively inhibit activation ORs. In this study, we...
The molecular receptive range (MRR) of a mammalian odorant receptor (OR) is the set structures that activate OR, while distribution these across odor space tuning breadth OR. Variation in thought to be an important property ORs, with MRRs receptors varying from narrowly broadly tuned. However, defining OR technical challenge. For practical reasons, screening panel covers must limited sparse coverage many potential space. When screened such panel, ORs different specificities, but equal...