A5062699319- Biochemical Acid Research Studies
- Multiple Sclerosis Research Studies
- Macrophage Migration Inhibitory Factor
- Amyotrophic Lateral Sclerosis Research
- Neuroinflammation and Neurodegeneration Mechanisms
- HIV Research and Treatment
- Cytokine Signaling Pathways and Interactions
- Systemic Lupus Erythematosus Research
- Inflammasome and immune disorders
- Neurological Disorders and Treatments
- Tryptophan and brain disorders
- HIV/AIDS drug development and treatment
- Neurogenesis and neuroplasticity mechanisms
- Herpesvirus Infections and Treatments
- Inflammation biomarkers and pathways
- Nuclear Receptors and Signaling
- Ultrasound and Hyperthermia Applications
- Pituitary Gland Disorders and Treatments
- NF-κB Signaling Pathways
- Ultrasound Imaging and Elastography
- Otitis Media and Relapsing Polychondritis
- Systemic Sclerosis and Related Diseases
- Genomics, phytochemicals, and oxidative stress
- Cholinesterase and Neurodegenerative Diseases
- Hops Chemistry and Applications
Oregon Health & Science University
2008-2021
VA Portland Health Care System
2019-2021
Portland VA Medical Center
2004-2017
Multiple Sclerosis Center of Atlanta
2016
European Institute of Oncology
2012
United States Department of Veterans Affairs
2009
Veterans Health Administration
2008
Oregon National Primate Research Center
1995
Multiple sclerosis (MS) is the leading cause of neurological disability in young adults, affecting some two million people worldwide. Traditionally, MS has been considered a chronic, inflammatory disorder central white matter which ensuing demyelination results physical [Frohman EM, Racke MK, Raine CS (2006) N Engl J Med 354:942-955]. More recently, become increasingly viewed as neurodegenerative neuronal loss, axonal injury, and atrophy CNS lead to permanent clinical disability. Although...
The role that dietary interventions can play in multiple sclerosis (MS) management is of huge interest amongst patients and researchers but data evaluating this limited. Possible effects a very-low-fat, plant-based intervention on MS related progression disease activity as measured by brain imaging symptoms have not been evaluated randomized-controlled trial. Despite use modifying therapies (DMT), poor quality life (QOL) be significant problem with fatigue being one the common disabling...
Oligodendrocyte processes wrap axons to form neuroprotective myelin sheaths, and damage in disorders, such as multiple sclerosis (MS), leads neurodegeneration disability. There are currently no approved treatments for MS that stimulate repair. During development, thyroid hormone (TH) promotes myelination through enhancing oligodendrocyte differentiation; however, TH itself is unsuitable a remyelination therapy due adverse systemic effects. This problem overcome with selective agonists,...
Lipoic acid (LA) is an antioxidant that suppresses and treats animal model of multiple sclerosis (MS), experimental autoimmune encephalomyelitis. The purpose this study was to determine the pharmacokinetics (PK), tolerability effects on matrix metalloproteinase-9 (MMP-9) soluble intercellular adhesion molecule-1 (sICAM-1) oral LA in patients with MS. Thirty-seven MS subjects were randomly assigned one four groups: placebo, 600 mg twice a day, 1200 once day day. Subjects took capsules for 14...
Lipoic acid is a natural anti-oxidant available as an oral supplement from number of different manufacturers. administered subcutaneously effective therapy for murine experimental autoimmune encephalomyelitis, model multiple sclerosis. The aim this study was to compare serum lipoic levels with dosing in patients sclerosis mice receiving subcutaneous doses acid. We performed pharmacokinetic studies after single dose 1200 mg Patients received one the three racemic formulations randomly: tablet...
To describe Japanese macaque encephalomyelitis (JME), a spontaneous inflammatory demyelinating disease occurring in the Oregon National Primate Research Center's (ONPRC) colony of macaques (JMs, Macaca fuscata).JMs with neurologic impairment were removed from colony, evaluated, and treated supportive care. Animals humanely euthanized their central nervous systems (CNSs) examined.ONPRC's JM was established 1965 no cases JME occurred until 1986. Since 1986, 57 JMs spontaneously developed...
Multiple sclerosis is the most common chronic disabling disease in central nervous system young to middle aged adults. Depression multiple (MS) affecting between 50–60% of patients. Pilot studies unipolar depression report an improvement when omega-3 fatty acids are given with antidepressants. The objective this study was investigate whether acid supplementation, as augmentation therapy, improves treatment-resistant major depressive disorder (MDD) people MS. We performed a randomized,...
In multiple sclerosis (MS), compromised blood-brain barrier (BBB) integrity contributes to inflammatory T cell migration into the central nervous system. Matrix metalloproteinase-9 (MMP-9) is associated with BBB disruption and subsequent CNS. The aim of this paper was evaluate effects omega-3 fatty acids on MMP-9 levels migration. Peripheral blood mononuclear cells (PBMC) from healthy controls were pretreated two types acids, eicosapentaenoic acid (EPA), docosahexaenoic (DHA). Cell...
Abstract We have demonstrated previously the ability of antioxidant α lipoic acid (ALA) to suppress and treat a model multiple sclerosis (MS), relapsing experimental autoimmune encephalomyelitis (EAE). describe effects ALA its reduced form, dihydrolipoic (DHLA), on transmigration human Jurkat T cells across fibronectin barrier in transwell system. DHLA inhibited migration dose‐dependent fashion by 16–75%. matrix metalloproteinase‐9 (MMP‐9) activity 18–90% cell supernatants. GM6001, synthetic...
We have previously demonstrated that thyromimetics stimulate oligodendrocyte precursor cell differentiation and promote remyelination in murine demyelination models. investigated whether a thyroid receptor-beta selective thyromimetic, sobetirome (Sob), its CNS-targeted prodrug, Sob-AM2, could prevent myelin axonal degeneration experimental autoimmune encephalomyelitis (EAE). Compared to controls, EAE mice receiving triiodothyronine (T3, 0.4 mg/kg), Sob (5 mg/kg) or Sob-AM2 had reduced...
Abstract Although multiple sclerosis (MS) has traditionally been considered to be an inflammatory disease, recent evidence brought neurodegeneration into the spotlight, suggesting that accumulated damage and loss of axons is critical disease progression associated irreversible disability. Proposed mechanisms axonal degeneration in MS posit cytosolic subsequent mitochondrial Ca 2+ overload, accumulation pathologic reactive oxygen species (ROS), dysfunction leading cell death. In this context,...
Lipoic acid, an antioxidant, has beneficial effects in experimental acute optic neuritis and autoimmune encephalomyelitis. Optical coherence tomography can detect retinal nerve fiber layer thinning, representing axonal degeneration, approximately 3-6 months after neuritis.To determine whether lipoic acid is neuroprotective neuritis.A single-center, double-blind, randomized, placebo controlled, 24-week trial. Intervention included 6 weeks of once daily (1200 mg) or within 14 days diagnosis....
We describe the molecular cloning of a serogroup 2 simian retrovirus (SRV; D2/RHE/OR) and present sequence its envelope (env) glycoprotein gene 3' long terminal repeat region. This report documents first infectious clone SRV provides env verification genetic diversity among isolates.
Fast, effective, and rapid processing of central nervous system (CNS) tissue with good preservation myelin, especially in from diseased mice, is important to many laboratories studying neurosciences.In this paper, we describe a new method process embed CNS mice. Spinal cords optic nerves naive C57BL/6 mice were used standardize the microwave protocol following perfusion fixative. The was processed embedded using embedding protocol.We observed that well preserved quality light electron...