A5104082840- Neurological Disorders and Treatments
- Retinal Diseases and Treatments
- Diagnosis and treatment of tuberculosis
- Retinoids in leukemia and cellular processes
- Lipid metabolism and disorders
- Electrolyte and hormonal disorders
- Tuberculosis Research and Epidemiology
- Advanced Glycation End Products research
- S100 Proteins and Annexins
- Macrophage Migration Inhibitory Factor
- AI in cancer detection
- Health and Well-being Studies
- Diabetes Management and Education
- Travel-related health issues
- Restless Legs Syndrome Research
- Lung Cancer Research Studies
- Intestinal Malrotation and Obstruction Disorders
- Health, psychology, and well-being
- Structural Response to Dynamic Loads
- Bipolar Disorder and Treatment
- COVID-19 diagnosis using AI
- Electroconvulsive Therapy Studies
- Diabetes Management and Research
- Gastrointestinal motility and disorders
- Estrogen and related hormone effects
Government Medical College
2024
Memorial Sloan Kettering Cancer Center
2022-2024
Louisiana State University Health Sciences Center Shreveport
2022-2023
Nirma University
2020-2022
Johns Hopkins University
2022
Yale University
2022
Jaipur Golden Hospital
2022
Kathmandu University
2022
Dhulikhel Hospital
2022
Takeda (United States)
2019
Abstract Purpose: Inhibition of the cyclin D-cyclin dependent kinase (CDK)4/6-INK4-retinoblastoma pathway can overcome acquired or de novo treatment resistance to endocrine monotherapy. Responses monotherapy in advanced endometrial cancer (EC) are suboptimal, perhaps due genomic alterations that promote estrogen receptor (ER)-independent D1-CDK4/6 activation. We hypothesized addition abemaciclib, a CDK4/6 inhibitor, antiestrogen therapy with fulvestrant will be an effective therapeutic...
Background: Postprandial hyperglycemia considered to be a major risk factor for cerebrovascular complications. Objective: The current study was designed elucidate the beneficial role of voglibose via in-silico in vitro in-vivo studies improving postprandial glycaemic state by protection against strokeprone type 2 diabetes. Material and Methods: In-Silico molecular docking virtual screening were carried out with help iGEMDOCK+ Pymol+docking software Protein Drug Bank database (PDB). Based on...
Background: Tuberculosis (TB), as a communicable disease, is an ongoing global epidemic that accounts for high burden of mortality and morbidity. Drug-resistant TB strains are one the hurdles in controlling problem. most common opportunistic infection people living with human immunodeficiency viruses (PLHIV). To accelerate progress toward goal ending by 2035, it imperative to outline incidence trends India. Aims Objectives: This study aims provide deep insights into recent India from 2018...
Background: Out of many atherosclerotic complications, peripheral arterial disease (PAD) is also important one. To prevent morbidity and mortality related with PAD, early detection must, possible by duplex screening. This study aims at screening for PAD in patients type 2 Diabetes mellitus.Methods: single centered cross- sectional, observational conducted department internal medicine DMCRI- a tertiary care hospital. A total 140, diabetes were screened ultrasound after taking informed consent...
5521 Background: ONA-XR is a type I full progesterone antagonist that inhibits progesterone-mediated PR activation and stabilizes association with corepressors. GCT (98% of cases PR+), LGSOC (58% PR+) EEC (67% are hormonally driven cancers generally have poor responses to chemotherapy. Methods: This an open-label, single-institution basket study in patients PR+ recurrent (cohort 1), 2), or 3) (NCT03909152). Eligible required receipt >1 prior line chemotherapy, measurable disease by RECIST...
The Coronavirus Pandemic triggered by SARS-CoV-2 has wreaked havoc on the planet and is expanding exponentially. While scanning methods, including CT scans chest X-rays, are commonly used, artificial intelligence implementations also deployed for COVID-based pneumonia detection. Due to image biases in X-ray data, bilateral filtration Histogram Equalization used followed lung segmentation a U-Net, which successfully segmented 83.2\% of collected dataset. lungs fed into Quadruplet Network with...
Introduction: There are many effective prevention interventions available for those experiencing occupational exposure, and post exposure prophylaxis (PEP) is one of them. Different studies worldwide have shown low utilization PEP HIV due to lack adequate knowledge.
 Objective: The purpose this study was assess the knowledge on among nurses.
 Methodology: Descriptive cross-sectional research design used all 130 nurses working in a private hospital Biratnagar were sample....
TAK-981 is a small molecule inhibitor of the SUMOylation enzyme cascade which currently in Phase I clinical trial (NCT03648372). selectively inhibits activity SUMO activating enzyme, forming covalent adduct between and SUMO, thereby decreasing levels SUMOylated proteins. A central feature pharmacological inhibition production type IFNs immune cells, promoting both innate adaptive responses.TAK-981 demonstrates antitumor activity, including complete regression (CR) some tumors,...
Abstract Chronic hyperglycemia induces activation of the polyol‐sorbitol pathway, which is a major contributor to microvascular complications like stroke. The current study was designed elucidate therapeutic role α‐glucose inhibitor in chronic hyperglycemia‐induced impaired polyol pathway and associated micro‐complications. Male albino‐Wistar rats (200–250 g) were treated with voglibose 10 mg kg −1 day /p.o. for 2 weeks before middle cerebral artery occlusion; 72 hr after surgery,...
Background & Objectives:Acute pain is common after cardiac surgery and can keep patients fromparticipating in activities that prevent postoperative complications especially respiratory complications.Accurate assessment understanding of are vital for providing satisfactory control andoptimizing recovery.Our aim the study was to compare relief post-operative outcome receiving Tramadolvia Thoracic epidural versus intravenous method coronary artery bypass graft surgery.Methodology: Sixty...
Nociceptive pain arises from the stimulation of specific receptors.These receptors respond to heat, cold, vibration, stretch and chemical stimuli released damaged cells.A use non-steroidal anti-inflammatory drugs (NSAIDs) is routine in management pain.Although effective at reducing inflammation, long term NSAIDs associated with known side effects.Herbal Ayurvedic products are widely perceived as safe due their natural origin historical clinical use.Hence present study, an attempt was made...
INTRODUCTION Glycated haemoglobin levels are routinely measured in type 2 diabetes mellitus to monitor their glycaemic control. Lipid disorder is common issues either independently or association with Diabetes mellitus. We aim establish the between and lipid profile patients attending our centre. MATERIAL AND METHODS This hospital based cross-sectional study conducted on 161 out-patient department of internal medicine from 10/02/2079 20/04/079 at Devdaha Medical College Research Institute...
Introduction: Gastroparesis is a disorder with delayed gastric emptying in the absence of mechanical obstruction. There limited literature regarding association esophagitis and gastritis gastroparesis patients comparison to non-gastroparesis patients. In this study, we compared esophagogastroduodenoscopy (EGD) findings Methods: A retrospective study was performed on undergoing per oral endoscopic pyloromyotomy (GPOEM) procedure randomly selected without documented history who underwent an...
Introduction: Gastroparesis is a debilitating condition characterized by delayed gastric emptying, resulting in various gastrointestinal symptoms. Patients with gastroparesis frequently experience comorbid psychiatric disorders, which negatively impact the quality of life and are likely influenced brain-gut network dysfunction. We aimed to characterize longitudinal effect anxiety, depression, or bipolar disorder on healthcare resource utilization adults primarily hospitalized diagnosis...
Abstract Background- By the year 2031, an anticipated 194 million Indian population will be aged 60 years or above. They are more prone to various infections due lowered immunity and Tuberculosis (TB) is one of them. The use diagnostic methods for TB needs investigated in geriatric population. Material methods: A cross-sectional study was conducted from 1 st January 2022 31 December 2022. All patients above were enrolled. Their sputum samples subjected CBNAAT positive tested by LPA detection...
Cooling towers are designed to handle the heat rejected from power plant by keeping it cool without damaging whole structure. These large structures with small thickness. An attempt has been made study effect of blast load on cooling tower. tower analysed for assuming fixity at base. The pressure is calculated using IS 4991:1968. Variable explosive distances taken behaviour Structure modelled and in ANSYS 16.2. terms deflection, stresses strain.
Perfusion Index (PI) is the ratio of pulsatile blood flow to non-pulsatile or static in peripheral tissues. It a new parameter tried for predicting hypotension during spinal anaesthesia. Our aim was observe as an early predictor under anaesthesia patients undergoing elective surgeries. In this observational study, 30 between age group 18-50years and belonged ASA I II category were taken. Spinal performed with 3-4 ml injection Bupivacaine 0.5% (hyperbaric) at L3–L4 interspace. Following heart...
Introduction: Gastric per oral endoscopic pyloromyotomy (GPOEM) has been performed in the last 7 years or so. Many studies have shown that GPOEM is 80% effective reducing nausea and vomiting patients with refractory gastroparesis (Gp) mean procedure time of about 1 hr. However, all reported outcomes were from earlier stage patients. In this study, we compare short-term our first recent 16 Methods: Our who underwent 06/2015 to 07/2016 (Group A) 07/2021 01/2022 B) enrolled study. Patients’...
Background: Metformin for type 2 diabetes mellitus has more beneficial effect with few side effects like vitamin B12 deficiency. So, this study aimed to determine the level of in patients using metformin and its association dose duration use. Methods: This was descriptive, cross-sectional, hospital-based study. A total 128 diabetic than 6 months were enrolled. After taking informed consent, considering exclusion criteria, serum quantified by chemiluminescent enzyme immunoassay. Vitamin...
Introduction: Bariatric surgery (BS) is a widely used modality of treatment in patients with morbid obesity. The lifetime risk these needing Endoscopic Retrograde Cholangio-Pancreatography (ERCP) has increased. ERCP this population time-consuming and technically challenging due to altered anatomy. Despite several techniques, there are complications associated each type ERCP. Our aim was assess trends outcomes BS patients. Methods: We utilized the Nationwide Inpatient Sample (NIS) database...