A5101695992- Cardiac Ischemia and Reperfusion
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cell death mechanisms and regulation
- Mitochondrial Function and Pathology
- Liver Disease Diagnosis and Treatment
- Dialysis and Renal Disease Management
- Acute Kidney Injury Research
- Chronic Kidney Disease and Diabetes
- Cardiovascular and Diving-Related Complications
- Spectroscopy Techniques in Biomedical and Chemical Research
- Nutritional Studies and Diet
- Physical Activity and Health
- NF-κB Signaling Pathways
- Congenital Heart Disease Studies
- Cardiac Arrhythmias and Treatments
- Renal function and acid-base balance
- Mass Spectrometry Techniques and Applications
- Nitric Oxide and Endothelin Effects
- Metabolomics and Mass Spectrometry Studies
Dalian Ocean University
2025
Ministry of Natural Resources
2025
Capital Medical University
2023-2024
Nanjing General Hospital of Nanjing Military Command
2024
Nanjing Medical University
2024
Beijing Friendship Hospital
2023-2024
Capital University
2023
Queen Mary Hospital
1999
To examine any potential links between remnant cholesterol (RC) and comorbid chronic kidney disease (CKD) in individuals with prediabetes type 2 diabetes mellitus (T2DM).
Regulated necrosis (necroptosis) and apoptosis are important biological features of myocardial infarction, ischaemia-reperfusion (I/R) injury, heart failure. However, the molecular mechanisms underlying necroptosis remain elusive. Ischaemic preconditioning (IPC) is most powerful intrinsic cardioprotection against I/R injury. In this study, we aimed to determine whether IPC suppresses I/R-induced mechanisms.
Myocardial ischemia-reperfusion (I/R) injury is a prevalent cause of myocardial injury, involving series interconnected pathophysiological processes. However, there currently no clinical therapy for effectively mitigating I/R injury. Here, we show that p85α protein levels increase in response to through comprehensive analysis cardiac proteomics, and confirm this the I/R-injured murine heart failing human myocardium. Genetic inhibition mice activates Akt-GSK3β/Bcl-x(L) signaling pathway...
There is a lack of sufficient information on the impact physical activity (PA) and dietary quality (DQ) mortality in patients with chronic kidney disease (CKD), no study has yet examined relationship between combined effects PA DQ risk death CKD representative adult population.
Background: The myocardial protective effects of activating the PI3K/Akt pathway have been documented, however, impact p85α, which is a regulatory subunit class IA PI3K, on injury remains elusive.Methods: A mouse model ischemia-reperfusion (I/R) and hypoxia/reoxygenation (H/R) in cardiomyocytes were utilized. role p85α was investigated through genetic depletion mice, overexpression mediated by adenovirus, knockdown using siRNA cardiomyocytes. Transcriptomic analysis, immunoprecipitation...
123 Ischemia-reperfusion injury is an important cause of early renal allograft dysfunction. Nitric oxide (NO·) has been implicated in the pathogenesis this process. We studied effect mycophenolate mofetil (MMF) on generation NO·in vivo after ischemia-reperfusion using electron paramagnetic resonance (EPR) and spin trapping technique. Renal was induced by clamping left pedicle male Balb/c mice for 30 minutes, followed 15 minutes reperfusion. The received either placebo, MMF 40mg/kg/d,...