A5001864058- Cellular Mechanics and Interactions
- Signaling Pathways in Disease
- Cell Adhesion Molecules Research
- 14-3-3 protein interactions
- Wound Healing and Treatments
- Microbial Natural Products and Biosynthesis
- Collagen: Extraction and Characterization
- Fibroblast Growth Factor Research
- Bone Tissue Engineering Materials
- Phagocytosis and Immune Regulation
- Endoplasmic Reticulum Stress and Disease
- Chronic Lymphocytic Leukemia Research
- Cardiac Fibrosis and Remodeling
- Acute Lymphoblastic Leukemia research
- Skin and Cellular Biology Research
- Immune Cell Function and Interaction
University of South Australia
2015-2024
South Australia Pathology
2013-2024
Centre for Cancer Biology
2013-2024
Objective: Increased macrophage recruitment in the early stages of wound healing leads to an excessive inflammatory response associated with elevated fibrosis and scarring. This relies upon integrins on surface monocytes that regulate their migration extravasation from circulation into site, where they differentiate macrophages. The aim this study was determine if inhibiting monocyte burns would reduce macrophages numbers lead reduced inflammation scar formation. Approach: Scald were created...
Chronic non-healing wounds negatively impact on quality of life and are a significant financial drain health systems. The risk infection that exacerbates co-morbidities in patients necessitates regular application wound care. Understanding mechanisms underlying impaired healing therefore key priority to inform effective new generation treatments. Here, we demonstrate 14-3-3-mediated suppression signaling through ROCK is critical mechanism inhibits the diabetic wounds. Accordingly,...
While it is now well appreciated that the extracellular matrix (ECM) exerts biomechanical cues direct critical cellular behavior, including cell proliferation, differentiation, migration, and survival, molecular mechanisms underlying these remain mysterious. It has long been known ECM also a source of biochemical influence processes, but way interact with biomechanics remains largely unknown. The systematic study relationships hampered by paucity models tools to interrogate them. Studies...