A5082354924- Cell Adhesion Molecules Research
- Atherosclerosis and Cardiovascular Diseases
- Immune cells in cancer
- Adipokines, Inflammation, and Metabolic Diseases
- Chemokine receptors and signaling
- Cancer, Lipids, and Metabolism
- Cholesterol and Lipid Metabolism
- Cytokine Signaling Pathways and Interactions
- Gene expression and cancer classification
- RNA Interference and Gene Delivery
- Cardiac Imaging and Diagnostics
- Systemic Lupus Erythematosus Research
- Cardiovascular Health and Disease Prevention
- Protease and Inhibitor Mechanisms
- Bioinformatics and Genomic Networks
- Ubiquitin and proteasome pathways
- Connective tissue disorders research
- Eosinophilic Esophagitis
- Computational Drug Discovery Methods
- Fibroblast Growth Factor Research
- interferon and immune responses
- Cerebrovascular and Carotid Artery Diseases
Maastricht University
2005-2021
Maastricht University Medical Centre
2021
Formation of foam cell macrophages, which sequester extracellular modified lipids, is a key event in atherosclerosis. How lipid loading affects macrophage phenotype controversial, with evidence suggesting either pro- or anti-inflammatory consequences. To investigate this further, we compared the transcriptomes foamy and non-foamy macrophages that accumulate subcutaneous granulomas fed-fat ApoE null mice normal chow fed wild-type vivo. Consistent previous studies, LXR/RXR pathway genes were...
We focus on similarities in the transcriptome of human Kupffer cells and alveolar, splenic, atherosclerotic plaque-residing macrophages. hypothesized that these macrophages share a common expression signature. performed microarray analysis mRNA from subsets (4 patients) developed novel statistical method to identify genes with significantly similar levels. Phenotypic functional diversity between macrophage subpopulations reflects their plasticity respond microenvironmental signals. Apart...
The formation of foamy macrophages by sequestering extracellular modified lipids is a key event in atherosclerosis. However, there controversy about the effects lipid loading on macrophage phenotype, with vitro evidence suggesting either pro- or anti-inflammatory consequences. To investigate this vivo we compared transcriptomes and non-foamy that accumulate experimental subcutaneous granulomas fat-fed ApoE null mice normal chow-fed wild-type mice, respectively. Consistent previous studies...
Foam cell macrophage (FCM) formation is an early event in atherosclerosis that precedes both fibrous cap development and subsequent rupture; FCM have been implicated events. To understand this further we compared the transcriptomes of non-foamy macrophages (NFM) produced subcutaneous sponges implanted into fat-fed ApoE null or C57Bl6 mice, respectively (n=4 each). RNA samples high quality by A260/280>2 were on Illumina bead chips. Differential expression was classified as significant...